The present invention relates to a continuous micro-electro-flow reactor system for ultra-fast, oxidant free, CC coupling reaction for making symmetrical biaryls and analogs thereof. This invention further relates to the said process for preparation of antiviral drug, daclatasvir of general formula I.

A Liquid, comprising an hydrophobic flavonoid derivative electrochemically non-active, that is capable of restoring its electrochemical activity, the concentration of the flavonoid derivative being 10 ppm by weight or less, and an organic substance in an amount of 90% by weight or more.

A device for synthesizing a radiotracer includes a microfluidic chip having a concentration module configured to concentrate and capture a radioactive reagent from a radioactive regent mixture, a reaction chamber in fluidic communication with the concentration module and configured to synthesize a radiotracer by reaction of the concentrated radioactive reagent and a radiotracer precursor therein, and a purification module in fluidic communication with the reactor chamber and configured to purify the synthesized radiotracer. The device also includes a heating means positioned in relation to the microfluidic chip for heating the microfluidic chip during evaporation and reaction; and a first valve fluidically coupled with the concentration module and the reaction chamber and a second valve fluidically coupled with the reaction chamber and the purification module for operably controlling transit of various substances or mixtures among the concentration module, the reaction chamber and the purification module.

A microfluidic device for performing physical, chemical or biological treatment to at least one packet without contamination.

A microfluidic device for performing physical, chemical or biological treatment to at least one packet without contamination.

A method for generating a hybrid reaction flows feedstock gas that is also a plasma medium through microchannels. Plasma is generated with the plasma medium via excitation with a time-varying voltage. UV or VUV emissions are generated at a wavelength selected to break a chemical bond in the feedstock gas. The UV or VUV emissions are directed into the microchannels to interact with the plasma medium and generate a reaction product from the plasma medium. A hybrid reactor device includes a microchannel plasma array having inlets and outlets for respectively flowing gas feedstock into and reaction product out of the microchannel plasma array. A UV or VUV emission lamp has its emissions directed into microchannels of the microchannel plasma array. Electrodes ignite plasma in the microchannels and stimulating the UV or VUV emission lamp to generate UV or VUV emissions. One common or plural phased time-varying voltage sources drive the plasma array and the UV or VUV emission lamp.

An apparatus includes a substrate having a recess and a multitude of particles arranged in the recess. A first portion of the particles is joined to a porous structure by means of a coating. A second portion of the particles is not joined by means of the coating. The first portion of the particles is arranged closer to an opening of the recess than the second portion of the particles so that a leaking of the second portion of the particles from the recess through the opening is prevented.

A photovoltaic apparatus comprising: at least one photovoltaic surface electrically connected to a set of photovoltaic electrodes; and a chemical reactor electrically connected to the set of photovoltaic electrodes. The chemical reactor enables N pairwise fluid contacts among k chemical fluids, with k2 and N4 and comprises: a reaction layer extending in a plane subtended by two directions; N chemical cells, each including two circuit portions, designed for enabling circulation of two of the k chemical fluids, respectively, the two circuit portions intersecting each other, thereby enabling one pairwise fluid contact for the two of the k chemical fluids; and a fluid distribution circuit comprising: k sets of inlet orifices sequentially alternating along lines parallel to one of the two directions; and k sets of outlet orifices sequentially alternating along lines parallel to the inlet orifices, and wherein, each circuit portion connects an inlet orifice to an outlet orifice.

The invention is a high-throughput voltage screening crystallographic device and methodology that uses multiple micro wells and electric circuits capable of assaying different crystallization condition for the same or different proteins of interest at the same of different voltages under a humidity and temperature controlled environment. The protein is solubilized in a lipid matrix similar to the lipid composition of the protein in the native environment to ensure stability of the protein during crystallization. The invention provides a system and method where the protein is transferred to a lipid matrix that holds a resting membrane potential, which reduces the degree of conformational freedom of the protein. The invention overcomes the majority of the difficulties associated with vapor diffusion techniques and essentially reconstitutes the protein in its native lipid environment under cuasi physiological conditions.

The present disclosure provides an apparatus for synthesizing a biopolymer, a method for preparing an apparatus for synthesizing a biopolymer, and a method of synthesizing a biopolymer. The apparatus comprises (a) a substrate comprising atop surface and a plurality of wells, wherein each of the plurality of wells comprises a first electrode disposed on the bottom of the well and a linker attached to the sides of the well; and (b) a fluidic chamber system disposed on the top surface of the substrate.