Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 l). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein.

The disclosed invention relates to a method for restarting a synthesis gas conversion process which has stopped. The synthesis gas conversion process may be conducted in a conventional reactor or a microchannel reactor. The synthesis gas conversion process may comprise a process for converting synthesis gas to methane, methanol or dimethyl ether. The synthesis gas conversion process may be a Fischer-Tropsch process.

According to various embodiments, a method is provided that comprises washing an array of DNA-coated beads on a substrate, with a wash solution to remove stacked beads from the substrate. The wash solution can include inert solid beads in a carrier. The DNA-coated beads can have an average diameter and the solid beads in the wash solution can have an average diameter that is at least twice the diameter of the DNA-coated beads. The washing can form dislodged DNA-coated beads and a monolayer of DNA-coated beads. In some embodiments, first beads for forming an array are contacted with a poly(ethylene glycol) (PEG) solution comprising a PEG having a molecular weight of about 350 Da or less. In some embodiments, slides for forming bead arrays are provided as are systems for imaging the same.

The present disclosure is directed to systems and methods for reforming a hydrocarbon fuel to increase the cetane value of the hydrocarbon fuel. The system includes a microstatic mixer and a microchannel reactor downstream of the microstatic mixer. The microchannel reactor includes a microchannel with an NHPI catalyst coated onto the walls of the microchannel. A hydrocarbon fuel and an oxygen-containing gas are combined and mixed in the microstatic mixer to produce a combined stream and the combined stream is passed through the microchannel. The microchannel reactor includes a heat transfer system. The hydrocarbon fuel and oxygen-containing gas are contacted in the microchannel in the presence of the catalyst at a reaction temperature sufficient to produce a reformed hydrocarbon fuel having a cetane value greater than a cetane value of the starting hydrocarbon fuel.

The present disclosure is directed to systems and methods for reforming a hydrocarbon fuel to increase the cetane value of the hydrocarbon fuel. The system includes a microstatic mixer and a microchannel reactor downstream of the microstatic mixer. The microchannel reactor includes a microchannel with an NHPI catalyst coated onto the walls of the microchannel. A hydrocarbon fuel and an oxygen-containing gas are combined and mixed in the microstatic mixer to produce a combined stream and the combined stream is passed through the microchannel. The microchannel reactor includes a heat transfer system. The hydrocarbon fuel and oxygen-containing gas are contacted in the microchannel in the presence of the catalyst at a reaction temperature sufficient to produce a reformed hydrocarbon fuel having a cetane value greater than a cetane value of the starting hydrocarbon fuel.

The present disclosure provides fluidic devices and fluidic device assemblies, including microfluidic devices and cartridges comprising the same, that in illustrative embodiments, can be used to make particles or protein precipitates, or to monitor precipitate formation. The fluidic devices typically include channels that connect a reaction well to an inlet port and an outlet port, and a fluidic constriction channel that is configured to help retain fluids in the reaction well and/or promote mixing within the reaction well. In some aspect, fluidic devices are interconnected into fluidic assemblies that can be used in continuous process methods.

The present invention relates to an apparatus for producing trichlorosilane from tetrachlorosilane in an efficient manner. The apparatus includes an inlet through which reaction raw materials including a metal silicon powder dispersed in liquid tetrachlorosilane enter, a hole through which a gaseous reaction raw material is fed, an outlet through which reaction products including trichlorosilane exit, a tubular reactor in which the reaction raw materials entering through the inlet react with each other during flow, and means for impeding the flow of the fluids to cause collision of the fluids during flow.

According to some aspects, described herein is an automated droplet-based reactor that utilizes oscillatory motion of a droplet in a tubular reactor under inert atmosphere. In some cases, such a reactor may address current shortcomings of continuous multi-phase flow platforms.

A flow reactor system and methods having tubing useful as polymerization chamber. The flow reactor has at least one inlet and at least one mixing chamber, and an outlet. The method includes providing two phases, an aqueous phase and a non-aqueous phase and forming an emulsion for introduction into the flow reactor.

The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.