A device for synthesizing a radioisotope-labelled target tracer includes a microfluidic chip having an SCX module configured to concentrate and capture a radioisotope from a radioisotope solution and release the captured radioisotope therefrom, an SAX module configured to purify the released radioisotope from the SCX module, and an passive in-plane mixing/reaction module configured to mix the purified radioisotope with a target precursor and perform labelling reaction to synthesize the radioisotope-labelled target tracer therein. The device also includes a heating means positioned in relation to the microfluidic chip for heating the microfluidic chip during the labelling reaction; and a first valve fluidically coupled with the SCX and SAX modules and a second valve fluidically coupled with the SAX module and the in-plane mixing/reaction module for operably controlling transit of various substances or mixtures among the SCX module, the SAX modules and the in-plane mixing/reaction module.

A modular reactor device has an outer housing, a reaction chamber, a fluid pathway connected to the reaction chamber, and a valve to control flow of fluid within the device. The outer housing has a plurality of connection ports including: a fluid input and a fluid output; an electrical input; and a pneumatic input. Either the electrical input or the pneumatic input is connected to the valve to provide for control of the valve, and either the fluid input or the fluid output is connected to the reaction chamber or the fluid pathway. Other aspects provide a base station for receiving and controlling a modular reactor device and methods for manufacturing the modular reactor device and for performing reactions using a modular reactor device.

The instant disclosure is related to fluidic distributors, fluidic systems, and associated methods and articles. Certain embodiments are related to fluidic distributors that comprise bays including fluidic connections with relative positions that substantially correspond to each other. In some embodiments, a fluidic distributor may comprise bays with electrical interfaces with relative positions that substantially correspond to each other.

Aspects of the present invention provide a modular reactor device having an outer housing, and a plurality of components contained within the outer housing, the components including: a reaction chamber; a fluid pathway connected to the reaction chamber; and a valve arranged to control flow of fluid within the device, wherein the outer housing has a plurality of connection ports providing connections from the exterior of the device to the interior, the connection ports including: a fluid input and a fluid output; an electrical input; and a pneumatic input; wherein either the electrical input or the pneumatic input is connected to the valve to provide for control of the valve, and either the fluid input or the fluid output is connected to the reaction chamber or the fluid pathway. Other aspects provide a base station for receiving and controlling a modular reactor device and methods for manufacturing the modular reactor device and for performing reactions using a modular reactor device.

The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

A device for synthesizing a radiotracer includes a microfluidic chip having a concentration module configured to concentrate and capture a radioactive reagent from a radioactive regent mixture, a reaction chamber in fluidic communication with the concentration module and configured to synthesize a radiotracer by reaction of the concentrated radioactive reagent and a radiotracer precursor therein, and a purification module in fluidic communication with the reactor chamber and configured to purify the synthesized radiotracer. The device also includes a heating means positioned in relation to the microfluidic chip for heating the microfluidic chip during evaporation and reaction; and a first valve fluidically coupled with the concentration module and the reaction chamber and a second valve fluidically coupled with the reaction chamber and the purification module for operably controlling transit of various substances or mixtures among the concentration module, the reaction chamber and the purification module.

Systems and methods for synthesizing chemical products, including active pharmaceutical ingredients, are provided. Certain of the systems and methods described herein are capable of manufacturing multiple chemical products without the need to fluidically connect or disconnect unit operations when switching from one making chemical product to making another chemical product.

The invention generally provides systems and methods for producing a chemical product. In certain embodiments, the invention provides systems that include a chemical product production unit. The chemical production unit includes a plurality of microfluidic modules configured to be fluidically coupled to each other in an arrangement that produces a chemical product from an input of a plurality of starting reagents that react with each other due to conditions within the plurality of microfluidic modules through which the starting reagents flow. The system also includes a droplet dispenser fluidically coupled to the chemical product production unit that forms and dispenses droplets of the chemical product.

A channel assembly is disclosed, which may comprise a microfluidic channel. Methods of manufacture are also disclosed as are detectors and detector components which may comprise such a channel assembly. An example is a detection apparatus comprising: a detector for detecting a substance of interest; and a pneumatic system comprising a microfluidic channel assembly comprising a first microfluidic channel for dispensing vapour to the detector, wherein the first microfluidic channel comprises a groove in a surface of a polymer body and a wall of the first channel is provided by a film bonded to the surface of the body over the groove.