A synthetic method and catalyst for preparing 3-(3-oxo-2-pentyl)cyclopentyl dimethyl malonate are disclosed. The synthetic method uses 2-pentyl-2-cyclopentenone and dimethyl malonate as raw materials, and reacts them in the presence of a catalyst to prepare 3-(3-oxo-2-pentyl)cyclopentyl dimethyl malonate, the catalyst is a basic ionic liquid, the pH value of the basic ionic liquid is greater than or equal to 10, and the catalyst is prepared by a method comprising the steps of: mixing the nitrogen-containing heterocyclic compound with an aliphatic carboxylate or hydroxyl aliphatic carboxylate or fluorophosphate under stirring. The synthetic method is environmentally friendly, stable in reaction and low-cost, and the conversion of 2-pentyl-2-cyclopentenone is significantly improved due to the use of the above-mentioned basic ionic liquid as catalyst.

This invention describes the methodology to produce solid heterogeneous chiral organocatalysts that can be used in condensation reactions. The catalysts can be recovered in a simple manner by filtration and can also be reused.

This invention describes the methodology to produce solid heterogeneous chiral organocatalysts that can be used in condensation reactions. The catalysts can be recovered in a simple manner by filtration and can also be reused.

The present invention relates to air stable, binary Ni(0)-olefin complexes and their use in organic synthesis.

The present invention discloses a diphenylamine-linked chiral bis(oxazoline) ligand without C.sub.2-symmetry of formula 3 and its synthesis method and application in an asymmetric catalytic reaction, wherein C.sub.2-symmetry is lost by introducing different groups into the diphenylamine backbone to realize precise control of electronic effect of the ligand backbone. An anthranilic acid derivative and an orthochlorobenzoic acid derivative are used as starting materials to prepare a compound of formula 1, and then the compound of formula 1 is reacted with a chiral amino alcohol compound to prepare a -bishydroxy amide compound of formula 2, and the compound of formula 2 is further subjected to condensation to obtain the diphenylamine-linked chiral bis(oxazoline) ligand without C.sub.2-symmetry of formula 3. The present invention also provides an application of a catalyst formed by coordination of the diphenylamine-linked chiral bis(oxazoline) ligand without C.sub.2-symmetry with copper salt, zinc salt, nickel salt, iron salt or rhodium salt, in an asymmetric catalytic reaction. ##STR00001##

Provided here are methods of making derivatives and prodrugs of substituted morpholines or pharmaceutically acceptable salts thereof. Further provided are methods of making derivatives and prodrugs of substituted morpholines having the following chemical structure:

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