A first aspect of the invention relates to a syringe housing which can have the following elements: a syringe body which has a first open end and a second open end, a first channel being formed between the two ends; a first membrane which is arranged such that the membrane extends substantially perpendicularly to the longitudinal direction of the first channel over the cross-section thereof; a syringe body attachment which has a first open end and a second open end, a second channel being formed between the two ends; a second membrane which is arranged such that the membrane extends substantially perpendicularly to the longitudinal direction of the second channel over the cross-section thereof; wherein the second open end of the syringe body and the first open end of the syringe body attachment are designed so as to be connectable in a formfitting manner and thus form the syringe housing, the first channel and the second channel form a continuous channel in the connected state of the syringe housing, and the first membrane and the second membrane define an extraction volume in the region of the continuous channel. Furthermore, different embodiments provide a pipette device which is designed for the automatic use of the syringe housing according to the invention.

Pipette assembly comprising a pipette device, a pipette tip, and an expanding mandrel collet coupling device coupling the tip to the pipette device, the coupling device comprising: circumferentially spaced apart segments, an annular base disposed below the segments and comprising a distal portion, an elastomeric element circumscribing the distal portion, and upwardly extending circumferentially spaced apart arms attached at first ends to the annular base and having upper free ends each supporting a different one of the segments configured to expand between a first and a second greater circumference for engaging a first interior working surface of the tip in concurrence with the elastomeric element sealing against a second interior working surface below the first surface and in concurrence with an abutment between a disk exteriorly disposed about a medial portion of the arms and a stepped interior shoulder of the tip disposed between the first and second working surfaces.

The present invention relates to a pipette dispensing block with an improved design for the piston chambers. In a multichannel pipetting block with a grid or array of pipetting piston of any order, the individual piston chambers are individually manufactured using the injection molding process. The individual piston chambers are assembled into a grid or single line array and held together by upper and lower plates in combination with either stabilizing posts or walls. The piston chambers are designed and assembled with a dual o-ring design at the tip and a tip sealing gasket at the bottom to provide the air-tight seal that is required for optimum pipetting performance. When combined with pistons and a motor-driven lifting plate for the pistons, the entire assembly forms a forms a multichannel pipetting block

The invention is directed to methods and devices for efficient separation of plasma irons whole blood which are suitable for point of care use in resource poor environments, in some embodiments, elements of such devices comprise (a) a sample collection receptacle (SCR) with at least one port, the sample collection receptacle capable of holding a predetermined volume of a sample of undiluted whole blood drawn through a port; (b) a filter chamber having an inlet and an outlet, and containing at least one filter capable of separating plasma from blood cells as sample passes from an inlet side to an outlet side of the at least one filter whenever the filter chamber is placed in Quid communication with a port of the sample collection receptacle; and (c) a manually driven pump operationally associated with the SCR and filter chamber for (i) drawing a predetermined volume of sample into ore SCR by a first user action and (ii) driving the predetermined volume at a substantially constant linear flow under a pressure not exceeding 2 psi from the SCR through the filter chamber and the outlet of the filter chamber by a second user action.

A pipetting system is disclosed that includes a pipette head including a multichannel air displacement system for aspirating and dispensing liquids, a pipetting system base that includes a linear guide system along which the pipette head may be moved vertically with respect to the pipetting system base, and counterbalance means for counterbalancing at least a portion of a weight of the pipette head.

A non-displasive pipette is provided. The non-displasive pipette is configured for connection to a tip having a fluid therein. The tip includes an orifice to allow for the discharge of the fluid therefrom. The non-displasive pipette includes a body defining a chamber therethrough and having first and second opposite ends. The second end of the body is configured for connection to the tip. A plunger is slidably received in the chamber at the first end of the body. The plunger is moveable in the chamber between an extended position and a discharge position wherein the fluid is urged from tip through the orifice. An air discharge arrangement is configured to allow air from the chamber to escape therefrom and to maintain the fluid in the tip in response to connection of the second end of the body to the tip.

A sliding seal [4] is operated within a bore [1] by means of magnetic attraction to an externally positioned and operated ring magnet [10] thus enabling a burette to be filled through the jet [3] like a syringe and remove the need for a control tap.

An apparatus includes a housing, defining an inner volume, and an actuator mechanism movably disposed therein. The actuator mechanism is configured to be transitioned from a first configuration to a second configuration to define a pre-sample reservoir fluidically couplable to receive a pre-sample volume of bodily-fluid via an inlet port of the housing. The actuator mechanism is movable from a first position to a second position within the housing after the pre-sample reservoir receives the pre-sample volume such that the housing and the actuator mechanism collectively define a sample reservoir to receive a sample volume of bodily-fluid via the inlet port. The outlet port is in fluid communication with the sample reservoir and is configured to be fluidically coupled to an external fluid reservoir after the sample volume is disposed in the sample reservoir to transfer at least a portion of the sample volume into the external fluid reservoir.

A pipetting unit (2) with capacitive liquid detection comprises: a pressure tube (10); a shield (12) disposed around the pressure tube (10); a coupling (14) for temporarily attaching a pipetting tip (4) to the pipetting unit (2), wherein when the pipetting tip (4) is connected, an electrical connection is established between the pressure tube (10) and the pipetting tip (4); and an electric circuit (20) coupled to the pressure tube (10) and the shield (12), wherein the electric circuit (20) is configured to apply a time-variable electrical signal to the pressure tube (10), said time-variable electrical signal permitting a capacitive detection of a contact between the pipetting tip (4) and a pipetting liquid (112) when the pipetting tip (4) is connected, and wherein the electric circuit (20) is configured to connect the shield (12) to ground.

Nanoliter pipette assembly. The assembly includes a housing containing a working fluid in a working fluid chamber therein and includes a moveable piston within the housing, the piston moveable by a linear actuation mechanism for contact with the working fluid. A tip portion is provided that includes a diaphragm deformable to engage an inner portion of the tip. It is preferred that the diaphragm have a projecting three-dimensional structure for direct contact with a liquid.