A device for extracting plasma from a fluid collection tube comprising: a tubular barrel having sidewall surrounding a lumen which extends between proximal and distal ends thereof, the tubular barrel forming a tip at a distal end; a barrel seal movingly seated within the lumen of the tubular barrel, the barrel seal closing and sealing the proximal end of the tubular barrel; a tube seal having a proximal end, a distal end, and a lumen extending therebetween, the proximal end having a frustoconical or chamfered face, the tube seal having an outer diameter sized to sealingly engage with an inner surface of the fluid collection tube, and an inner diameter sized to sealingly engage with an outer surface of the tip of the tubular barrel, the tube seal mounted on the tubular barrel such that the tip of the tubular barrel extends into the tube seal lumen.

A method of treating an isolated area of a sample with a liquid is disclosed. The method has the steps of generating an isolated area of a sample by a first fluid reservoir where the first fluid reservoir enclosing a distal end of a second fluid reservoir and the isolated area of the sample being sealed towards the remaining area of the sample, bringing the isolated area of the sample into fluid connection with the second fluid reservoir, dispensing a fluid from the second fluid reservoir into the first fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a first direction, and aspirating the fluid from the first fluid reservoir into the second fluid reservoir thereby generating a fluid flow on the sample at the isolated area in a second direction.

A manually actuated chromatography device comprising a chamber for receiving a liquid sample, a pump with a metering valve, and a chromatography element, wherein the pump moves a predetermined volume of liquid from the sample chamber to the chromatography element.

This disclosure is directed to a device and a system for picking a target analyte of a suspension. A picker introduces at least one force, such as by a magnetic gradient and/or by a pressure gradient, to extract the target analyte from a sample.

A pipette tip extension attachable to a pipette tip is disclosed. The pipette tip extension has a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip. The pipette tip extension further has a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity, and a coating for interacting with a fluid present in a fluid uptake area.

A metering head comprising: a carrier having parallel attachments, a stop plate having first holes through which the attachments extend, each attachment having: a tube with a projecting supporting protrusion, a sleeve with a tapering at the bottom end, an elastomer O-ring that encloses the tube, and the sleeves can be shifted between a release position and a clamping position; in the clamping position, the sleeves with the taperings are pressed into the O-rings and expand them, a first shifting apparatus shifting the sleeves between the release position and the clamping position, a second displacement apparatus shifting the stop plate between a stop position and an ejection position, wherein the second shifting apparatus has rocker arms pivotably mounted on the carrier, transmission shafts that are coupled to the sleeves, and ejection shafts which are securely connected to the stop plate.

A pipette comprises a housing extending from a lower end to an upper end and a neck extending from the lower end of the housing and configured to hold a pipette tip. A stroke rod comprising an upper end and a lower end is configured to displace a tip plunger in the pipette tip. A drive apparatus is configured to displace the stroke rod to: (1) aspirate a liquid specimen into the pipette tip held on the neck; and (2) to eject the specimen from the pipette tip by means of a tip plunger positively connected to the stroke rod. At least one locking sleeve is arranged coaxially with the stroke rod and configured to be displaceably guided toward the stroke rod in the housing, The locking sleeve is configured to inhibit release of a tip plunger from the stroke rod.

A pipette and sealing pipette tip can include features for generating a secure mounting engagement between the pipette and pipette tip without the need for protrusions on the pipette tip used for providing an interference fit and avoiding the need for a separate air-tight seal directly between the piston and shaft of the pipette.

Misalignment of intersecting devices on a diagnostic instrument may be detected and remediated using a system comprising components such as an accelerometer, a plurality of strain gauges and a device comprising a processor and a memory (e.g., a computer). In such a system, the accelerometer may be adapted to detect movement of the diagnostic instrument. The device comprising the processor and the memory may be configured to, for each of the structural elements of the diagnostic instrument, determine whether an alignment change has taken place in that structural element based on analyzing measurements made by the plurality of strain gauges. The device comprising the processor and the memory may also be configured to, for each structural element where an alignment change is determined to have taken place, trigger a remediation for each device from a set of devices impacted by the alignment change of that structural element.

A multichannel pipetting head comprises a plunger actuator comprising at least one groove with an upper border, and a lower border. A plurality of plunger-cylinder units, wherein each plunger-cylinder unit comprises a cylinder and a plunger comprising a plunger head. The plunger head comprises a projecting upper abutment region adjoining the upper border, a projecting lower abutment region adjoining the lower border and laterally offset relative to the projecting upper abutment region, a plurality of guides. Each of the cylinders is coupled to a neck and held on each of the plurality of guides. During lateral movement of the plurality of guides, the plunger head is configured to tilt in the groove and to be held with the upper abutment region abutting the upper border and with the lower abutment region abutting the lower border of the groove due to restoring forces that occur during tilting in the plunger-cylinder units.