A metering head for a metering machine having a carrier having parallel attachments for picking up pipette tips, wherein each attachment has: a tube having a supporting protrusion at the bottom end, at least one sleeve which surrounds the tube and can be axially shifted on the tube, and at least one elastomer O-ring which surrounds the tube, a pressure plate above the sleeves having a plurality of first holes through which the tubes extend, wherein the pressure plate can be shifted along the tubes from a release position into a clamping position where the sleeves are pressed, at the bottom ends, against the adjacent O-rings, and the O-rings are expanded to clamp pipette tips; and a first shifting apparatus connected to the pressure plate moving the pressure plate between the release position and clamping position.

Disclosed here are pipette tips useful for receiving and dispensing liquids, which include a plurality of beveled interior ribs.

A pipette tip extension attachable to a pipette tip is disclosed. The pipette tip extension has a proximal end, a distal end, and an exterior wall extending between the proximal end and the distal end. The exterior wall has an outer side and an inner side and forms at the proximal end a reception aperture for inserting a pipette tip. The pipette tip extension further has a bottom at the distal end, an inner cavity enclosed by the inner side of the exterior wall and the bottom, one or more distance elements arranged at the inner side of the exterior wall and protruding into the inner cavity, and a coating for interacting with a fluid present in a fluid uptake area.

Provided in part herein are pipette tip rack assemblies having one or more of the following features: (i) having a plurality of pipette tip receptacle plates, each plate having an array of pipette tips, stacked upon one another supported by a rack base; (ii) each plate having one or more projections from the proximal or distal surface and, optionally, orifices that oppose the projections of the next plate in the stack, and (iii) the rack base having a proximal surface with one or more orifices or projections that oppose the projections or orifices of the plate in the stack. Also provided are methods of dispensing pipette tips from pipette tip rack assemblies and manufacturing pipette tip rack assembly components.

A multichannel pipetting head comprises a plunger actuator comprising at least one groove with an upper border, and a lower border. A plurality of plunger-cylinder units, wherein each plunger-cylinder unit comprises a cylinder and a plunger comprising a plunger head. The plunger head comprises a projecting upper abutment region adjoining the upper border, a projecting lower abutment region adjoining the lower border and laterally offset relative to the projecting upper abutment region, a plurality of guides. Each of the cylinders is coupled to a neck and held on each of the plurality of guides. During lateral movement of the plurality of guides, the plunger head is configured to tilt in the groove and to be held with the upper abutment region abutting the upper border and with the lower abutment region abutting the lower border of the groove due to restoring forces that occur during tilting in the plunger-cylinder units.

An auto-pipetting apparatus includes a dispensing head with at least one pipetting tip mandrel having an elongated stud body with an insertion end. The at least one pipetting tip mandrel mates with a pipetting tip. A first adjustable seal, disposed on the elongated stud body, and a second adjustable seal, disposed on the elongated stud body, seal the pipetting tip mated to the at least one pipetting tip mandrel. The first adjustable seal defines a snub surface. The snub surface effects a substantially continuous circumferential contact seal with radially impinging contact between the pipetting tip and the at least one pipetting tip mandrel. The second adjustable seal is adjustable between a disengaged position and an engaged position and effects a releasable grip and another substantially continuous circumferential contact seal between the pipetting tip and the at least one pipetting tip mandrel around the pipetting tip.

Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

Pipette tip couplers, pipette tips, coupler and tip combinations, and methods for coupling and decoupling a pipette tip to or from, respectively, a pipette tip coupler mounted on a pipette device, are disclosed. The pipette tip couplers include an elastomeric element and an annular ring shaped raceway. When the pipette tip is mounted on the pipette tip coupler, the annular ring shaped raceway abuts a first portion of the interior surface of the circumscribing sidewall of the pipette tip, and the elastomeric element abuts a second portion of the interior surface of the circumscribing sidewall of the pipette tip.

The present disclosure provides methods and devices for sample extraction.

The invention relates to a pipetting device for receiving and dispensing fluid volumes. The pipetting device has a drive device with an electric motor and a gear device with a first output device. The gear device is driven by the electric motor by means of a rotary motion and is designed to transmit a rotary motion of the electric motor to the first output device. According to the invention, the gear device has a second output device and is designed to transmit a rotary motion of the electric motor to the second output device.