According to the present invention there is provided an assembly comprising, a needle unit comprising n hollow needles wherein n is greater than one, and wherein each hollow needle can receive a respective sample fluid; a flow cell unit comprising m flow cells wherein m is greater than one, each flow cell having an input and an output, and a test surface on which ligands can be provided located between the input, and output; a means for consecutively moving sample fluids, from each of said n hollow needles respectively, into all said m flow cells, so that said sample fluids flow consecutively through the same flow cells. There is further provided a corresponding method of screening a sample fluid for molecules which can bind to predefined ligands.

According to the present invention there is provided an assembly, which can be used to screen sample fluids for predefined molecule, the assembly comprising, a needle unit (2) comprising n hollow needles (2a-h), wherein n is greater than one; a flow cell unit (3) comprising m flow cells, wherein m is greater than one, each flow cell having an input (3a,d) and an output (3a-d), and a test surface on which ligands can be provided located between the input and output; a first selector valve unit (4) which is fluidly connected between the needle unit (2) and flow cell unit (3), and wherein said first selector valve unit (4) is configured so that it is operable to selectively fluidly connect any one it the n hollow needles (2a-h) with said m flow cells in said flow cell unit; a pumping means (12) which is selectively operable to provide negative pressure; a second selector valve unit (6) which is fluidly connected between said pumping means, and the output (3a-d) of each flow cell (3a-d) in the flow cell unit (3). There is further provided a corresponding method of screen sample fluids for predefined molecule.

Examples disclosed herein relate to a device. Examples to determine a dispense routine for a default dilution of a compound according to a dispense request identifying a second dilution of the compound, and a dispense engine to control the dispense device to dispense at least a portion of the default dilution of the compound according to the dispense routine. In examples, the dilution engine is to determine the dispense routine by comparing the second dilution to the default dilution to determine whether the default dilution is dilutable to the second dilution.

Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

A microfluidic probe head is provided. The microfluidic probe head comprises a processing surface. The processing surface has a first and second aperture and a fluid injection channel, which leads to the first aperture. The microfluidic probe head comprises also a first fluid aspiration channel which leads to the second aperture. Thereby, the second aperture forms a slot in the processing surface. Furthermore, a microfluidic probe may be provided comprising the microfluidic probe head.

Disclosed is a product dispenser, comprising a cap and a reservoir for a product, wherein the reservoir has a protrusion and a piston engaging mechanism, wherein the cap has the followings: a pipette having an upper end orifice and a lower end orifice; a piston configured to move so as to create a suction to draw the product through the lower end orifice of the pipette of the product dispenser; a housing for the piston configured for the piston to slide between a high position and low position in the housing; a corresponding engaging mechanism configured to engage with the piston engaging mechanism of the reservoir, and also configured to move together with the piston; a button configured to dispense the product through the end orifice of the pipette, when the button is actuated; a chamber configured to change its volume depending on the movement of the piston and the movement of the button, wherein when the cap is capped on the reservoir in a direction of closing the product dispenser, the piston is moved by the protrusion, relatively to the housing to the high position in the housing, and the volume of the chamber decreases, wherein when the cap is uncapped on the reservoir in a direction of opening the product dispenser, the piston is moved relatively to the housing to a low position in the housing by the engagement of the piston engaging mechanism and the corresponding engagement mechanism, and the volume of the chamber increases, wherein this opening of the cap produces a suction of the product in the pipette, wherein when the button is actuated, the volume of the chamber decreases by which the product is dispensed from the pipette.

The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.

A fluidic device (10) is described. The fluidic device (10) comprises the first part (110) and the second part (120). The first part (110) comprises a first inlet (111) and a first outlet (112), mutually spaced apart. The second part (120) comprises a first chamber (121) arranged to contain a predetermined first amount A1 of a first fluid F1 therein and a first wall portion (122) arranged to contain, at least in part, the first fluid F1 in the first chamber (121). The fluidic device (10) is arrangeable in a first configuration, wherein the first part (110) is fluidically isolated from the first chamber (121). The fluidic device (10) is arrangeable in a second configuration, wherein the first inlet (111) and the first outlet (112) are fluidically coupled via the first chamber (121), whereby increasing a first pressure P1 in the first chamber (121) via the first inlet (111) urges at least a part of the predetermined first amount A1 of the first fluid F1 through the first outlet (112).

A system includes a reagent selector valve controllable to select a reagent flow path from a plurality of reagent flow paths, and a pump coupled to the reagent flow path to draw a liquid through the reagent flow path in accordance with a prescribed test protocol. The system includes a discharge flow path to expel the drawn liquid, and a flow meter to measure liquid displaced by the pump and that outputs data representative of the measured flow. The system also includes a processor to access the data and to determine a volume of the liquid displaced by the pump.

There is provided a sample ejection system for ejecting a sample from a flow of fluid, the system comprises: a fluid flow channel for receiving, in use, the flow of fluid; a fluid inlet channel connected to the flow channel and arranged to receive, in use, pressurised fluid; a fluid outlet channel connected to the flow channel at a location downstream in the flow direction of the flow of fluid and comprises an outlet. The system is arranged such that, in use, pressurised fluid is applied to the fluid flow channel via the fluid inlet channel to drive fluid from the region of the fluid flow channel between the fluid inlet and outlet channels through the fluid outlet channel and out of the outlet.