The transfer systems, devices, kits, and methods described here may be used to facilitate the transfer of a material (e.g., a fluid) to or from a donor container, e.g., to or from wells of a donor plate while leaving target agents attached to the wells. The systems may comprise a donor plate, a transfer adapter, and a receiver plate that may be coupled to form a transfer assembly. The transfer adapter may comprise a planar sheet and a plurality of openings, and it may be configured to regulate the flow of fluid out of the wells. The transfer assembly may be placed into a centrifuge, and the fluid transfer force produced by the centrifuge may cause fluid to flow out of the wells of the donor plate, through the openings in the transfer adapter, and into the receiver plate.

A system for single-use immunochemical tests, comprising a support equipped, along a main direction, with a plurality of housings, including —at least one first housing for the sample to be analyzed, —at least one second housing for substances to be combined with the sample during the test, —at least one third housing for a well carrying a substance to be combined with the sample during the test, characterized in that the surface of said at least one third housing of said support is opaque to light and said well is made of a material at least partially transparent to light, and in that said at least one third housing is —equipped with a through-hole on the bottom, so that a beam of light can pass through said bottom of the third housing and through said well, in order to conduct a colorimetric absorbance test, or —equipped with a closed bottom in order to conduct a luminescence test in the well, —so that said system uses a single type of well at least partly transparent to light to conduct colorimetric absorbance and luminescence tests.

A molecular diagnostics apparatus is provided. The molecular diagnostics apparatus is adapted to perform DNA chain replication to one sample. The molecular diagnostics apparatus includes a bracket, a central control module, a motor, a magnetic unit, a rotational carrier, a detection module and at least one power supply coil. The central control module is disposed on the bracket. The motor is disposed on the bracket, wherein the central control module drives the motor. The magnetic unit is disposed on the bracket, wherein the magnetic unit provides a magnetic field. The motor is adapted to rotate the rotational carrier. The rotational carrier is rotated relative to the bracket. The sample is disposed on the rotational carrier. The detection module is disposed on the rotational carrier. The power supply coil is coupled to the detection module, and disposed on the rotational carrier. The molecular diagnostics apparatus of the embodiment has a simpler structure and better reliability.

Methods for forming arrays of droplets, and associated arrays of droplets, are generally provided.

Described herein are cassettes and methods for using these cassettes for cryopreserving biomaterials (e.g., a bioengineered construct or natural tissue sample) by vitrification while reducing or preventing the loss of viability associated with conventional preservation methods.

Techniques are described for reducing the number of angles needed in structured illumination imaging of biological samples through the use of patterned flowcells, where nanowells of the patterned flowcells are arranged in, e.g., a square array, or an asymmetrical array. Accordingly, the number of images needed to resolve details of the biological samples is reduced. Techniques are also described for combining structured illumination imaging with line scanning using the patterned flowcells.

A sampling kit for tissue including a reaction chamber and a sampling device configured for mounting in the reaction chamber and providing a reaction volume defined between the base of the reaction chamber and the sampling device. The sampling device has a proximal handling portion and a distal scraping portion comprising a scraping formation configured to collect a sample of tissue when the distal scraping portion is rubbed against a surface of the tissue. The sampling device comprises an internal lumen configured for the supply of reaction liquid from a distal end of the tissue sampling device to the reaction volume via a distal aperture disposed in the distal scraping portion when the tissue sampling device is mounted in the reaction chamber. An automated high-throughput sampling and indexing system is also described.

Embodiments disclose apparatus, methods and software for performing biological screening and analysis implemented using an instrument platform capable of detecting a wide variety of cell-based secretions, expressed proteins, and other cellular components. The platform may be configured for simultaneous multiplexed detection of a plurality biological components such that a large number of discrete samples may be individually sequestered and evaluated to detect or identify constituents from the samples in a highly parallelized and scalable manner.

Blood typing systems and methods are provided. In one embodiment, the method may be achieved by applying a sample to a surface of a substrate having one or more binding agents immobilized thereon, wherein the one or more binding agents are capable of binding to one or more substances in the sample; substantially removing unbound material from at least a portion of the substrate having immobilized binding agent; and detecting substances bound to the one or more binding agents immobilized on the substrate; wherein the applying the sample to the surface of the substrate step is concurrent with the removing unbound material from at least a portion of the substrate step. Systems and other methods are also described and illustrated.

Disclosed herein is a sensor chip for parallelized magnetic sensing of a plurality of samples, a system for parallelized magnetic sensing of a plurality of samples and a method for probing a plurality of samples using optically addressable solid-state spin systems. The sensor chip comprises an optically transparent substrate comprising a plurality of optically addressable solid-state spin systems arranged in a plurality of sensing regions in a surface layer below a top surface of the substrate. The sensor chip further comprises a plurality of sample sites, wherein each sample site is arranged above a respective sensing region. The sensor chip has a light guiding system configured to provide an optical path through the substrate connecting each of the sensing regions.