The current invention relates to the method and apparatus to magnetically separate biological entities with magnetic labels from a fluid sample. The claimed magnetic separation device removes biological entities with magnetic labels from its fluidic solution by using a soft-magnetic center pole with two soft-magnetic side poles. The claimed device further includes processes to dissociate entities conglomerate after magnetic separation.

Methods and systems for sorting particles are provided. Methods and systems for sorting cell beads are provided. In some cases, cell beads may be sorted from particles unoccupied with cell derivatives. In some cases, singularly occupied cell beads may be sorted from unoccupied particles and multiply occupied cell beads.

A microfluidic device, intended for processing particles, in particular cells. This device includes a processing chamber with at least two elongated segments, one input seeding channel and one output seeding channel configured to define a seeding flow, and connection channels configured to allow the seeding flow through all the processing chambers serially.

The invention relates to a method for dispensing a liquid sample by means of a dispensing apparatus in which it is determined whether a particle condition is satisfied, wherein the determination comprises checking whether at least one target particle present in a liquid of the liquid sample is contained in a monitoring region of the dispensing apparatus, wherein the monitoring region comprises a discharge region and a buffer region, wherein the buffer region is a region from which the at least one target particle is movable into the discharge region during a time delay between the determination of whether the particle condition is satisfied and an output operation of the dispensing apparatus. The method is characterised in that it is determined that the particle condition is satisfied when the at least one target particle is arranged in the buffer region and no target particle is arranged in the discharge region, and that the liquid sample is dispensed onto a target particle carrier if the particle condition is satisfied.

A flow path device includes a first portion, and a second portion. The first portion includes a resin first body and a first reinforcement. In the first body, a first connector connects a first outer portion and a first joint having a groove pattern defining a first flow path.

The first reinforcement is between and bonded to the first outer portion and the first joint, and includes first protrusions protruding from the first body and including two specific-shaped portions. The second portion includes a resin second body and a second reinforcement. In the second body, a second connector connects a second outer portion and a second joint, and through-holes connect to the first flow path. The second reinforcement is between and bonded to the second outer portion and the second joint, and includes second protrusions protruding from the second body and including two specific-shaped portions.

To provide a microchip that is easily handled.

Provided is a microchip having a plate shape and including: a sample liquid inlet into which a sample liquid is introduced; a main flow path through which the sample liquid introduced from the sample liquid inlet flows; and a sorting flow path into which a target sample is sorted from the sample liquid, in which the sample liquid inlet and a terminal end of the sorting flow path are formed on a same side surface. Furthermore, a sample sorting kit including the microchip is also provided. Moreover, a microparticle sorting device on which the microchip is mounted is also provided.

A device (100) for visualization of one or more components in a blood sample is disclosed. In one aspect, the device (100) includes an imaging module (110), wherein the imaging module (110) includes a controllable illumination source (102) capable of emitting light in plurality of discrete angles; a tube lens (105); one or more objective lens (104); and an image capturing module (106). Additionally, the device (100) includes a channel (103) configured to carry the blood sample, wherein the channel (103) is capable of sorting the one or more components in the blood sample.

A method is for detecting a biomarker within a sample of blood. The method may include processing the sample of blood with a microfluidic blood plasma separator and a plasmonic array biosensor, and flowing the sample of blood over a sensing surface of the plasmonic array biosensor. The sensing surface of the plasmonic array biosensor may have an ssDNA aptamer against the biomarker. The method may further include binding the biomarker in the sample of blood to the ssDNA aptamer of the plasmonic array biosensor, and detecting the biomarker in the sample of blood based upon LSPR altering a reflected optical signal from the plasmonic array biosensor.

Electroacoustic device that includes a body, an electrode to be electrically powered, named hot electrode, and an electrode to be electrically grounded, named ground electrode. The body includes a piezoelectric part or the electroacoustic device further including a piezoelectric part different from the body. The hot electrode includes a hot track spiraling around a spiral axis. The radial step between two consecutive coils of the hot track decreasing radially from the spiral axis. The hot electrode and the ground electrode are arranged on the piezoelectric part such as to define a wave transducer configured to generate a focalised ultrasonic vortex propagating in the body and/or, when a fluid medium is acoustically coupled with the electroacoustic device, in the fluid medium.

Microfluidic devices and systems are provided. Methods for conducting immune assays with the devices and systems are also provided.