An oral care implement that includes a head having a face with a tuft hole therein. A plurality of bristles are disposed within the tuft hole and arranged in a bristle tuft that extends from the face of the head. The bristle tuft includes a first subset of the bristles and a second subset of the bristles. Each of the bristles has a longitudinal axis and a transverse cross-sectional profile having a major axis and a minor axis, the major axes of the bristles being longer than the minor axes of the bristles. The major axes of the bristles of the first subset may be non-parallel to the major axes of the bristles of the second subset.

A fluidic device holder configured to orient a fluidic device. The device holder includes a support structure configured to receive a fluidic device. The support structure includes a base surface that faces in a direction along the Z-axis and is configured to have the fluidic device positioned thereon. The device holder also includes a plurality of reference surfaces facing in respective directions along an XY-plane. The device holder also includes an alignment assembly having an actuator and a movable locator arm that is operatively coupled to the actuator. The locator arm has an engagement end. The actuator moves the locator arm between retracted and biased positions to move the engagement end away from and toward the reference surfaces. The locator arm is configured to hold the fluidic device against the reference surfaces when the locator arm is in the biased position.

There is provided a histology system that comprises a microtome configured to expose a face of a tissue block comprising a tissue sample embedded in an embedding material and remove one or more tissue sections from the sample, a hydration system configured to hydrate the tissue block by depositing a hydrating liquid on the face of the tissue block, and a transfer system configured to transfer the one or more tissue sections from the microtome to one or more slides. In some embodiments, the hydration system is configured to produce droplet condensation of the hydrating liquid and deposit the condensation on the face of the tissue block.

The invention relates to kits and components thereof used in the conduct of solid-phase binding assays.

A valve block assembly for a bottle attachment apparatus for handling liquids has a valve block, an intake valve insert and/or an exhaust valve insert, and a valve receptacle assigned to the respective valve insert. The valve insert is inserted in a replaceable and sealing manner in the valve receptacle. The valve insert has a stop portion, a fastening portion distinct therefrom and a sealing portion distinct from both. The associated valve receptacle has stop, fastening, and sealing portions matching the equivalent portions of the valve insert. When the valve insert is installed correctly both the stop portions and the sealing portions bear on one another in a planar manner.

A histologic tissue sample support device includes a tissue cassette a frame, and a lid. The tissue cassette has a recess including a body with at least one side wall and a bottom wall and is formed of material that can be successfully sectioned in a microtome and is resistant to degradation from solvents and chemicals used to fix, process and stain tissue. The tissue cassette is movably coupled to the frame. The lid is separably coupled to a peripheral portion of the frame. When the lid is separated from the peripheral portion, the lid and the tissue cassette are capable of moving from a first position to a second position with respect to the frame, and in the second position the bottom wall and at least a portion of the side wall extend beyond a bottom edge of the frame for sectioning in the microtome.

An extraction container includes a molded tubular body having openings at opposing first and second end thereof. A base cap is configured to obstruct a base opening disposed at the base of the tubular body. The base cap is integrally molded with the tubular body and connected thereto by a frangible connection. The base cap can be removed by breaking the frangible connection to de-obstruct the second opening. The first base cap and tubular body include integrally molded engagement features to permit the base cap to be reattached to the tubular body to re-obstruct the base opening. A removable foil or polymer seal obstructs a top opening disposed at the top end of the tubular body. A top cap and hinge are integrally molded with the tubular body and configured to re-obstruct the top opening following removal of the seal.

A microfluidic nucleic acid detection kit and a detection device are provided. The microfluidic nucleic acid detection kit is provided includes a kit body and a reagent card interconnected. The kit body can slide relative to the reagent card to control the kit to work. The microfluidic nucleic acid detection kit further includes a gas source cavity, a liquid cavity, a nucleic acid amplification cavity, and a gas tail cavity. The gas tail cavity communicates with the nucleic acid amplification cavity through an exhaust gas flow channel. The exhaust gas flow channel is provided with a check valve. The detection device includes the microfluidic nucleic acid detection kit, a first housing, a power module, a display module, a first heating module, and a first detection module. The microfluidic nucleic acid detection kit is removably inserted into the first housing.

Vial assemblies comprise a tubular body and a cap, the cap including a first portion configured to abut a lip of an open end of the tubular body, a threaded portion configured to couple to threading on an internal surface of the tubular body, and a second portion protruding from the threaded portion and extending into a cavity of the tubular body. Methods for storing and removing frozen samples from such vial assemblies are also described.

The present disclosure provides approaches for reducing tobacco-specific nitrosamines (TSNAs) in tobacco. Some of these approaches include genetically engineering tobacco plants to increase one or more antioxidants, increase oxygen radicle absorbance capacity (ORAC), or reduce nitrite. Also provided are methods and compositions for producing modified tobacco plants and tobacco products therefrom comprising reduced TSNAs.