A lateral flow assay (LFA) device includes a capillary pad and a sample port that holds the sample fluid before a hole is made in a cavity surface of the sample port. The LFA device includes a breaker with a tip to make a hole in the cavity wall of the sample port causing the sample fluid held inside the compartment to be applied to the capillary pad after the start of a test.

Disclosed here are kits comprising pre-packed stabilizing solutions for stabilizing combinations of biomarkers at room temperature. Such kits can be better adapted for sample collection at a subject's dwelling, thus easing the burdensome requirement of sample collection.

Systems and methods for improved flow properties in fluidic and microfluidic systems are disclosed. The system includes a microfluidic device having a first microchannel, a fluid reservoir having a working fluid and a pressurized gas, a pump in communication with the fluid reservoir to maintain a desired pressure of the pressurized gas, and a fluid-resistance element located within a fluid path between the fluid reservoir and the first microchannel. The fluid-resistance element includes a first fluidic resistance that is substantially larger than a second fluidic resistance associated with the first microchannel.

A fluid specimen collection, storage, transport, and testing cup contains a removable chromatographic strip-carrying cartridge and an axially moveable liquid specimen preserving caddy which moves between a first, pre-test position and a second, post-test position. During which a caddy drain is temporarily opened allowing an amount of liquid specimen deposited in the caddy to flow into the cup and contact the strips. Once in the second position, the drain is sealed for later confirmatory testing. The caddy is moved between the two positions by screwing a threaded lid more tightly onto the top opening of the cup. The axial range of the screw is limited by a removable obstruction collar. The caddy can include a liquid specimen containing chamber having a lower opening sealed by a frangible barrier.

The invention relates to a system is provided that comprises a lysis chamber, an amplification chamber and a fluorescence detection device. The fluorescence detection device (16) comprises - a detection chamber (42) configured to receive the amplification chamber (14) or the contents of the amplification chamber, - a light source (44), - an optical sensor (46), - energy supply means (48), - a wireless data interface (52) and - a controller (50).

The present disclosure relates to, inter alia, an easy-to-operate, fully closed component, which can be part of an instrument, for purification of biomolecules from biological samples, and subsequent transfer, and testing of the biomolecules, as well as an instrument comprising the component, and a method for using the component.

Lateral flow devices and methods are described. In one example, a device includes body extending between a first end and a second end. The body holds a liquid. The device also includes a swab extending from the first end of the body, a lateral flow test strip extending from the second end of the body, a first tube removably attached to the first end of the body and covering the swab, and a second tube removably attached to the second end of the body and covering the lateral flow test strip. The first end of the body includes a first valve that can be selectively opened by a user, and the second end of the body comprises a second valve that can be selectively opened by the user.

Instruments and methods for amplifying nucleic acids in a sample provided in a flexible, self-contained, substantially closed sample container.

A biological sample collection system can include a sample collection vessel having a sample collection chamber with an opening configured to receive a biological sample into the sample collection chamber. The biological sample collection system can additionally include a selectively movable sleeve valve configured to associate with the opening of the sample collection chamber. The biological sample collection system can additionally include a sealing cap that is configured to associate with the selectively movable sleeve valve and with the sample collection vessel. The sealing cap can include a reagent chamber having reagent(s) stored therein, and when the sealing cap is associated with the sample collection vessel, the selectively movable sleeve valve opens, dispensing the reagent(s) into the sample collection chamber.

The invention relates to a test set (1) for a photometric measuring device, comprising a mixing container (2) which has a filling opening (3) and comprising a metering container (8) which can be sealingly inserted into the filling opening (3) of the mixing container (2) and which contains a liquid reagent (13) in a closed cavity (9). The cavity (9) has a closure plunger (11), which can be moved axially in the cavity (9), at a first end of the metering container (8), said closure plunger generating a specifiable filling pressure in the reagent (13), and the metering container (8) has a closure membrane (10) at a second metering container and which can be inserted into the mixing container (2). According to the invention, the closure membrane (10) is equipped with a predetermined breaking point (20) which breaks open when the filling pressure is exceeded in a defined manner as a result of an axial movement of the closure plunger (11), said predetermined breaking point (20) of the closure membrane (10) being formed as a linearly extending material taper of the closure membrane (10), wherein the taper is arranged eccentrically in the region of an opening (24) in the base (23) of the substantially cylindrical metering container (8).