Described is a polymerase chain reaction (PCR) device including a PCR thermal block including a first substrate and heating units, a PCR chip including a second substrate and reaction chambers, and an unidirectional sliding driver for sliding the PCR chip relative to the PCR thermal block while maintaining a contact between the second substrate of the PCR chip and the first substrate of the PCR thermal block. The first and second heaters of each of the plurality of heating units are spaced apart from each other along a sliding direction, and the unidirectional sliding driver causes any reaction chamber in the PCR chip to have a sequential thermal contact from a heater of the plurality of heating units mounted at one end of the PCR thermal block to a heater of the plurality of heating units mounted at another end of the PCR thermal block.

The present invention describes several embodiments of a device that allows for the supporting, storage and deployment of large surface area thin film solid phase microextraction (TF-SPME) chemical samplers from within a sample fluid carrier. The utility of said supporting device originates from the process by which the extraction surface is stabilised within a sample carrying fluid for the extraction of chemical molecules from said sample carrying fluid. The device is also characterized by having a seating cavity, and moving mechanism or cap that can switch the supported TF-SPME chemical sampler between an open, sampling position or closed storage position.

Disclosed are devices and methods for performing biological and chemical assays, such as immunoassays and nucleic acid assays, more particularly a homogeneous assay that does not use a wash step by using the aggregation and de-aggregation processes of microparticles or nanoparticles.

The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.

The present invention provides a LAMP assay device comprising a heating chamber (5) adapted to receive a support rail (2) of at least one sample, in which the support rail (2) is inserted into it through a sample insertion opening (1), in addition, the heating chamber (5) comprises: at least one internal heating element (8a, 8b); a circuit of light-emitting elements (6) positioned on a front or rear wall; and a light sensor circuit (7) on a wall opposite the light emitting element circuit (6).

A device and a method for isolating a target from a biological sample are provided. The target is bound to solid phase substrate to form target bound solid phase substrate. The device includes a lower plate with an upper surface having a plurality of regions. The biological sample is receivable on a first of the regions. An upper plate has a lower surface directed to the upper surface of the lower plate. A force is positioned adjacent the upper plate and attracts the target bound solid phase substrate toward the lower surface of the upper plate. At least one of the upper plate and the lower plate is movable from a first position wherein the target bound solid phase substrate in the biological sample are drawn to the lower surface of the upper plate and a second position wherein the target bound solid phase substrate are isolated from the biological sample.

A holder (10) receives and stores laboratory vessels for samples, microorganisms, cell cultures or the like, with a housing (14), and at least one receptacle (20) for the laboratory vessels. The receptacle (20) extends along a loading axis (L) in the housing (14) and is configured such that the laboratory vessels can be introduced into the receptacle (20) and can be stacked on top of each other therein, wherein the receptacle (20) in the housing (14) has a loading opening (20a) to permit loading. On an underside (18) arranged remote from the loading opening (20a), the receptacle (20) has an unloading opening (20b), which can be closed by means of a closure mechanism (38) arranged in the housing (14). The closure mechanism (38) is provided with a slide (40, 42), via which the slide (40, 42) is movable to the unloading opening (20b) to permit closure and is movable from the unloading opening (20b) to an opening position to permit opening.

A device for collecting multiple samples for use by a single user while avoiding cross-contamination under adverse conditions is disclosed. A multiple sampling device comprising a single handle actuator with a trigger, connected to a shaft assembly further connected to a claw assembly for actuating a self-sealing sampling sphere in the process of collecting a desired sample, is disclosed. The sampling sphere comprises two halves that separate when the trigger and claw assembly are actuated, and close together when the trigger is released using springs on the claw assembly and sampling sphere. Additional sampling spheres are stored on the shaft assembly. In operation, once a sample is collected by one sampling sphere, the sampling sphere is exchanged with an empty sampling sphere stored on the shaft assembly.

The present disclosure provides an assay cartridge used in a PCR-based molecular diagnostic device. In one embodiment, the assay cartridge comprises (1) an elongated body having a proximal end, a distal end and a plurality of compartments arranged between the proximal end and the distal end, said plurality of compartments include at least a first pipette tip holder near the proximal end, and a second pipette tip holder near the distal end; and (2) a seal assembly covering the elongated body comprising a rigid frame which matches the top periphery of the elongated body, and an elastic top mounted on the rigid frame, the elastic top comprising a first sub-portion near the proximal end comprising a first ring structure that matches the first pipette holder, and a second sub-portion near the distal end comprising a second ring structure that matches the second pipette holder.

The present technology provides for an apparatus for detecting polynucleotides in samples, particularly from biological samples. The technology more particularly relates to microfluidic systems that carry out PCR on nucleotides of interest within microfluidic channels, and detect those nucleotides. The apparatus includes a microfluidic cartridge that is configured to accept a plurality of samples, and which can carry out PCR on each sample individually, or a group of, or all of the plurality of samples simultaneously.