A major challenge for the general use of “lab-on-a-chip” (LOAC) systems and point-of-care (POC) devices has been the generally complex and need for sophisticated peripheral equipment, such that it is more difficult than anticipated to implement low cost, robust and portable LOAC/POC solutions. It would be beneficial for chemical, medical, healthcare, and environmental applications to provide designs for inexpensive LOAC/POC solutions compatible with miniaturization and mass production, and are potentially portable, using compact possibly hand-held instruments, using reusable or disposable detectors. Embodiments of the invention address improved circuit elements for self-powered self-regulating microfluidic circuits including programmable retention valves, programmable trigger valves, enhanced capillary pumps, and flow resonators. Additionally embodiments of the invention allow for the flow direction within a microfluidic circuit to be reversed as well as for retention of reagents prior to sale or deployment of the microfluidic circuit for eased user use.

An aseptic manipulation system comprises first and second operation chambers, an aseptic manipulation chamber, and a control unit. The control unit controls the ventilation of the first operation chamber for more than a first specified number of times, after an object is introduced into the first operation chamber, and ventilates the second operation chamber for more than a second specified number of times that is greater than the first specified number of times, after the object is transferred into the second operation chamber from the first chamber.

A container includes a vial, cap, and one or more wireless transponders secured to the cap, the vial or a jacket to store and identify samples of biological material at cryogenic temperatures (e.g., vitrified biological samples), for instance held by cryopreservation storage devices. A specimen holder may be extend from the cap. The vial and/or cap includes ports or vents. A carrier includes a box, thermal shunt, thermal insulation to store and identify arrays of containers that hold cryopreservation storage devices with samples of biological material at cryogenic temperatures. Various apparatus include wireless transponders positioned and oriented to enhance range, and allow interrogation while retained in a carrier. Various apparatus can maintain the biological material at or close to cryogenic temperatures for prolonged period of times after being removed from a cryogenic cooler, and can allow wireless inventorying while maintaining the biological samples at suitably cold temperatures.

The present invention relates to a deepwell plate system, comprising a deepwell plate and a lid system which can be detachably fitted to the deepwell plate by snap- or clamp-fastening means so as to tightly seal the deepwell plate and to a method for the cultivation of cells within the deepwell plate system according to the present invention.

A screw cap lidded container for laboratory use includes a container body defining a chamber, a tubular section of the container body that is connected at the rear to the chamber and has a container opening in the front and an external thread on the outer periphery of the tubular section. There is a circumferential first sealing surface on the tubular section and at least one first projection, which projects from the container body at a peripheral position of the tubular section, and a screw cap having an internal thread on the inner periphery that can be screwed onto the external thread with thread play, a second sealing surface on the screw cap can be brought into sealing contact with the first sealing surface, and at least one second projection, which projects at a peripheral position of the screw cap.

A reagent container used in an automatic analysis apparatus capable of preventing reagent in the reagent container from spattering out of the reagent container even when the reagent container with large capacity is rotated at a high speed and an automatic analysis apparatus using the reagent container are provided. A reagent container 12 for an automatic analysis apparatus has a first opening 27 used for sucking reagent and a second opening 28 used for the filling of the reagent. The second opening 28 is provided with an attachable/detachable lid 29. The lid 29 is provided with an air vent 33, a first shield plate 30 and a second shield plate 31 for preventing spattering of the reagent through the air vent 33 due to a wave motion of the reagent.

A multiwell plate cover is provided, wherein the cover comprises a frame configured for attachment to a multiwell plate; a first movable guide member having two elongated side members that extend across the width of the plate, wherein a gap between the side members is substantially equal to a diameter of a single well in the multiwell plate and wherein the first movable guide member is slidable along the length of the frame; and a second movable guide member having two elongated side members that extend across the length of the plate, wherein a gap between the side members is substantially equal to a diameter of a single well in the multiwell plate and wherein the second movable guide member is slidable along the width of the frame, wherein the first and second movable guide member are configured to move independently from each other.

The present invention relates to systems and methods that utilize a combination of immunoassay and magnetic immunoassay techniques to detect an analyte within an extended range of specified concentrations. In particular, a device includes a housing, a heterogeneous surface capture immunosensor within the housing and configured to generate a first signal indicative of the concentration of the analyte in an upper concentration range, and a homogeneous magnetic bead capture immunosensor within the housing and configured to generate a second signal indicative of the concentration of the analyte in a lower concentration range.

Disclosed herein are methods and devices for preparing a dried reagent for long term storage and rehydrating and mixing the dried reagent.

A gas supply device for operation in an incubator allowing treatment of a culture within a shaker flask with gas independently of the composition and humidity of the gas atmosphere within the incubator individually supplies each shaker flask of the incubator with gas using a gas supply clamp detachably connected to the closure cap of each flask. The gas supply clamp has at least two elastic clamping jaws and a web connecting the clamping jaws to one another. The clamping jaws exert a clamping force on the side wall of the closure cap. The clamp is held in place by the elastic clamping jaws. Above a sterile filter in the closure cap, an individual gas atmosphere for treatment of the culture in the shaker flask is produced in a recess of the web above a gas passage in the closure cap.