A solution jetting device includes: a cylindrical member; a movable member that is movably fitted to a hollow portion of the cylindrical member; a first drive mechanism that moves the movable member; a first flow passage that connects a solution container, in which a solution containing a biological sample or containing a reagent to be reacted with a biological sample is contained, to the hollow portion; an openable and closable first on-off valve that is provided on the first flow passage; a jetting tool that jets the solution to an objective region; a second flow passage that connects the hollow portion to the jetting tool; an openable and closable second on-off valve that is provided on the second flow passage; a second drive mechanism as defined herein; and a control unit as defined herein.

Systems and methods for automatically packing resin into and unpacking resin from a reusable separation column for sample analysis are described. A reusable sample separation column embodiment includes, but is not limited to, a column body having a first end and a distal second end and defining an interior fluid flow pathway; a first port adjacent the first end and coupled to an inlet coupled to an expanded interior region, the inlet positioned between the first port and the expanded interior region to introduce resin slurry; an outlet coupled to a frit positioned between the outlet and the first port, the frit configured to retain resin of the resin slurry within the expanded interior region; and a second port coupled to a channel having a smaller cross-section than the second port, the channel configured to introduce a jet of fluid to resin positioned in the expanded interior region.

Systems and methods for controlled, inline introduction of chemical agents to an inline fluid sample are described. A method embodiment includes, but is not limited to, receiving a fluid sample with a valve; receiving a chemical agent with the valve; introducing the fluid sample and the chemical agent inline via a mixing port of the valve to produce a mixed sample; transferring the mixed sample to a second valve; directing the mixed sample to a sample holding loop fluidically coupled with the second valve; holding the mixed sample within the sample holding loop for a holding period of time to permit a reaction between the fluid sample and the chemical agent; and directing the mixed sample from the sample holding loop to an analytic instrument following expiration of the holding period of time.

Provided herein, in some embodiments, are rapid diagnostic tests to detect one or more target nucleic acid sequences (e.g., a nucleic acid sequence of one or more pathogens) having a seal component. In some embodiments, the pathogens are viral, bacterial, fungal, parasitic, or protozoan pathogens, such as SARS-CoV-2 or an influenza virus. Further embodiments provide methods of detecting genetic abnormalities. Diagnostic tests comprising a sample-collecting component, one or more reagents (e.g., lysis reagents, nucleic acid amplification reagents), a seal component, and a detection component (e.g., a component comprising a lateral flow assay strip and/or a colorimetric assay) are provided.

A reagent carrier includes: a cap configured to fit on an opening of a reaction vessel; and a reagent confined by the cap. The cap may be configured to release the reagent when a user manipulates the cap while the cap is fitted on the opening of the reaction vessel. For example, the reagent may be released when the user twists the cap from a first position to a second position or when the user pushes on a surface of the cap. The cap may be configured to seal the opening of the reaction vessel when the cap is fitted on the opening of the reaction vessel. In some implementations, the cap may be a blister cap containing the reagent. In some implementations, the cap may include a cage containing the reagent. In some implementations, the cap may include a deformable structure containing the reagent.

A method and system for processing a sample in a fluid is provided. An assembly comprising a cap prefilled with a fixative solution, a valve, and a container for storing a tissue sample are provided. The valve is adapted to be situated between the cap and the container such that fluid can flow from the cap into the container when the assembly is upright, but the fluid cannot backflow from the container to the cap when the assembly is horizontal or inverted.

A device for the reversible immobilization of biomolecules includes a container which can be filled with a liquid containing biomolecules and has an opening and a valve. The valve can be opened and closed by a closing mechanism for the controllable drainage of the liquid. Magnetic particles, to which the biomolecules can be immobilized can be arranged freely movable in the container. A magnet for fixing the magnetic particles in the container is arranged at the container, and the liquid can be removed from the container through the opening in the open state of the valve.

Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

Disclosed herein are cell processing systems, devices, and methods thereof. A system for cell processing may comprise a plurality of instruments each independently configured to perform one or more cell processing operations upon a cartridge, and a robot capable of moving the cartridge between each of the plurality of instruments.

A biological sample collection system can include (i) a sample collection vessel having an opening for receiving a biological sample, (ii) a selectively movable valve comprising a core and a collar disposed about the core, and (iii) a sealing cap coupled to the collar and comprising a reagent chamber for storing a measure of sample preservation reagent. The sealing cap is configured to associate—and form a fluid tight connection—with the sample collection vessel such that associating the sealing cap with the sample collection vessel causes a physical rearrangement of the core relative to the collar such that a fluid vent associated with the core is moved into fluid communication with the reagent chamber, thereby permitting sample preservation reagent to pass from the regent chamber to the sample collection vessel.