A substance purification device ensures that the interface between an aqueous liquid layer and an oil-based liquid layer is maintained in a stable manner. The substance purification device includes a washing flow channel, and an elution flow channel that communicates with the washing flow channel, the washing flow channel including a first part, and a second part that is smaller than the first part as to the cross-sectional area in a plane that is orthogonal to the direction in which the washing flow channel extends, an interface between a washing liquid and a fluid that is immiscible with the washing liquid being situated within the second part, the elution flow channel including a third part, and a fourth part that is smaller than the third part as to the cross-sectional area in a plane that is orthogonal to the direction in which the elution flow channel extends, an interface between an eluent and a fluid that is immiscible with the eluent being situated within the fourth part, the washing liquid being a liquid with which a substance-binding solid-phase carrier on which a substance is adsorbed is washed, and the eluent being a liquid with which the substance is eluted from the substance-binding solid-phase carrier.

In some instances, an apparatus can include a light sensitive imaging sensor having a surface to receive a fluid sample, a body to be moved relative to the light sensitive imaging sensor and having a surface to touch a portion of the fluid sample, and a carrier to move the body toward the surface of the light sensitive imaging sensor to cause the surface of the body to touch the portion of the fluid sample, so that as the surface of the body touches the portion of the fluid, the surface of the body (i) is parallel to the surface of the light sensitive imaging sensor, and (ii) settles on top of the fluid sample independently of motion of the carrier.

A multi-capillary column pre-concentration trap for use in various chromatography techniques (e.g., gas chromatography (GC) or gas chromatography-mass spectrometry (GCMS)) is disclosed. In some examples, the trap can include a plurality of capillary columns connected in series in order of increasing strength (i.e., increasing chemical affinity for one or more sample compounds). A sample can enter the trap, flowing from a sample vial to a relatively weak column to the relatively strongest column of the trap by way of any additional columns included in the trap, for example. In some examples, the trap can be heated and backflushed so that the sample exits the trap through the head of the relatively weak column. Next, the sample can be injected into a chemical analysis device for performing the chromatography technique (e.g., GC or GCMS) or it can be injected into a secondary multi-capillary column trap for further concentration.

Since a few kilovolts of an application voltage is necessary to take in a biological sample, an EWOD electrode, for example, is destroyed, and the electrode becomes non-reusable for moving a droplet. Therefore, an object of the present invention is to provide a biochemical cartridge usable for multiple times for taking in a biological sample by a capillary array, for example, and a biochemical analysis device using the biochemical cartridge. In order to solve the problem, the biochemical cartridge according to the present invention includes a passage through which a sample is transported, a plurality of electrodes disposed on the passage along a direction in which a sample is transported, the plurality of electrodes being provided to transport a sample, and an opening provided opposite to the plurality of electrodes disposed on a downstream side of the passage.

Methods, devices and systems for handling sample liquids, encapsulating liquids and magnetic particles are disclosed.

Devices, systems and methods for making and handling liquid samples are disclosed.

A nucleic acid detection plate comprises a piezoelectric sensor and at least a pipe flowing through the surface of the piezoelectric sensor, two valves intervally installed on the pipe relative to the upstream end of the piezoelectric sensor, the nucleic acid to be detected is blocked in the pipe between the two valves for isothermal amplification; the nucleic acid detection system comprises the nucleic acid detection plate described above, a thermostat capable of accommodating the nucleic acid detection plate; and a signal processor capable of being date connected to the piezoelectric sensor. The inventive method simplifies device structure through coordinated detection by combination of thermostatic amplification and piezoelectric sensing, and improves detection efficiency.

A multi-actuated micro-pipette controller is actuated in at least three different ways. First, the multi-actuated micro-pipette controller may be employed similar to a striper for denudation of cumulus cells and transfer of oocytes and embryos by depressing an actuator assembly operably coupled to a ballonet. Second, the multi-actuated micro-pipette controller may be actuated similar to a SWEMED™ denudation pipette by pressing directly on the ballonet while it is seated in a primary housing and a secondary housing, without employing an actuator assembly of the primary housing. Third, the multi-actuated micro-pipette controller may be actuated by removing the ballonet and employing it similar to a PASTEUR™ pipette.

Systems, methods, and devices for analyzing small volumes of fluidic samples, as a non-limiting example, less than twenty microliters are provided. The devices are configured to make a first sample reading, for example, measure an energy property of the fluid sample, for example, osmolality, make a second sample reading, for example, detecting the presence or concentration of one or more analytes in the fluid sample, or make both the first sample reading and the second sample reading, for example, measuring the energy property of the fluid sample as well as detecting the presence or concentration of one or more analytes in the fluid sample.

A dispensing device for dispensing a defined volume of a liquid from a closed container includes a housing and a spring loaded piston disposed therein. The housing has a holding chamber that includes chamber snap fit elements on the chamber wall, piston stop(s), and a bottom having a central opening with a tubular member extending therefrom. The spring loaded piston includes a push cap including snap fit arms extending from underside of a top pusher and a spring around a piston rod under the top pusher. The device is so configured that engagement modes between arm snap fit elements of the push cap and chamber snap fit elements of the holding chamber control a venting position and an injection starting position of the spring loaded piston, and abutment of the push cap with the piston stop(s) in the holding chamber controls an injection ending position of the spring loaded piston.