A cartridge comprises a housing; a sample mixing compartment disposed within the housing, the sample mixing compartment comprising: an activation pouch, and a sample collection region; and a gas transporter tube having a first end and a second end, the tube being disposed within the housing adjacent to the sample mixing compartment, wherein the sample mixing compartment is partially defined by a moveable door of the housing, the moveable door providing access to the sample mixing compartment when the door is in an open position and preventing access to the sample mixing compartment when the door is in a closed position; and wherein the door is configured to release contents of the activation pouch upon movement from the open position to the closed position.

A disposable cartridge comprises a cartridge body defining at least one syringe barrel having an barrel port configured to inject and aspirate assay fluids by displacement of a barrel plunger and at least one reaction chamber configured to receive and perform diagnostic testing on the assay fluids. The disposable cartridge also includes at least two rotors mounted for rotation to the cartridge body, each of the rotors defining a plurality of ports in fluid communication with at least one of the assay chambers of a respective one of the rotors. The rotors are selectively rotated such that a port of one rotor aligns with a port of the other rotor. At least one of the rotors is disposed in fluid communication with the syringe port of the syringe barrel such that assay fluids may flows from at least one of the assay chambers through the ports of the rotors by displacement of the barrel plunger.

The present disclosure provides devices, machines and methods for incubating or washing a biological sample. This disclosure provides a device comprising a motor and a control for the motor, a supporting frame comprising a receptacle, an assembly comprising a rotatable liquid storage container, a washing cassette, and a liquid collection and recovery tank. The disclosure also provides methods using the device.

The invention encompasses compositions and compounds for inhibiting CoV2 Spike GP and human ACE2 proteins and a 3D pharmacophore model described herein provides the means for rapid, high-throughput virtual screening of potential anti-CoV2 modulators thus facilitating, optimizing and speeding up the search for the discovery of a potent anti-COVID-19 agent and methods of treatment and prevention thereof.

A nucleic acid sequencing system may include non-planar substrates coupled to the outer surface of a rotating drum. The substrates may be curved and include a plurality of nucleic acid samples. A detection system, including for example an objective and a camera, may detect sequencing events on the non-planar substrate while the non-planar substrate is rotated relative to the detection system around a longitudinal axis of the drum by the actuation system.

An apparatus for vaccine generation includes a syringe with a cavity that includes a solution with photosensitizers. Microbial particles are added to the solution. A light source is capable of emitting one or more wavebands of light that are effectively absorbed by the one photosensitizers to generate singlet oxygen in the solution and other radical species that rapidly react with and damage lipids, proteins, DNA, and RNA of the microbial particles. This damage produces immunogens that can be applied as a vaccine to viruses and other infectious microbial particles. A plunger that fits within a proximal opening in the syringe is used for forcing the solution including the immunogens through the filter and out of the syringe while the photosensitizers, debris and unwanted microbial particles are trapped within the filter.

Disclosed herein are systems and methods for serial flow emulsion processes. Systems and methods as described herein result in reduced cross-contamination.

Disclosed herein are systems and methods for serial flow emulsion processes. Systems and methods as described herein result in reduced cross-contamination.

Stable operation of an ultrasonic vibrator of an ultrasonic cleaner and scattering prevention of a washing liquid are provided. The ultrasonic cleaner includes a washing tank 206 in which a washing liquid is reserved; an ultrasonic vibrator 205; a vibration head 209 provided with a neck 304 extended from the ultrasonic vibrator to the washing tank and a tip end portion 210 having a cylindrical hole 211 whose longitudinal direction is oriented to a perpendicular direction; and a first cover 601 having an opening corresponding to the neck and the cylindrical hole, in which the first cover is arranged to a height in contact with a liquid surface of the washing liquid such that it covers the washing tank.

A sample consumable that carries a microvolume of sample to a sample loader. The consumable is precisely aligned utilizing a double-alignment feature to the loader. The loader is based on a crank-slider geometry and allows for simple, one-handed operation for the user. Overall, the consumable and sample loader increase reproducibility of in-line sample loading and offers ease-of-use.