Provided herein are coded fluid paths. Also provided herein are devices and systems containing one or more of the coded fluid paths. Also provided herein are methods of using the coded fluid paths, devices, and systems provided herein.

A system and method for sample droplet processing, the system including a substrate, an electrode array network coupled to the substrate and configured to provide a pattern of controlled electric fields for manipulation of the set of sample droplets; a first layer in communication with the electrode array network, the first layer separating the electrode array network from fluid of the set of sample droplets; and a second layer opposing the first layer and displaced from the first layer to define a region wherein droplets of the set of sample droplets can reside. In some variations, the system can additionally include an electronics subsystem coupled to at least one of the substrate and the electrode array network, and a control module in communication with the electronics subsystem, wherein the control module generates and manipulates the pattern of controlled electric fields.

A centrifuge device and method for use are presented. The centrifuge device includes a housing, a chamber, a channel, and a cover. The housing includes a first port and a vent opening and is designed to rotate about an axis passing through a center of the housing. The chamber is defined within the housing and is coupled to the first port. A first portion of the chamber has a width that tapers between a first width at a first position and a second width at a second position within the chamber, the first width being greater than the second width. The channel is coupled to the second position of the chamber and arranged such that a path exists for gas to travel from the channel to the vent opening. The cover provides a wall that seals the chamber.

A microfluidic device includes a chamber, on two sides of which lying opposite each other in a first direction, a respective first distributor is provided in order to produce a laminar flow in the first direction. Each of the first distributors has at least one branching point, at which a channel is divided into at least two channels. The at least one branching point of the first distributor is arranged in such a way that a first connection channel is connected to a plurality of first connection points of the chamber by means of the first distributor.

A hydrodynamic shuttling chip device comprising an array of single-cell trapping units is disclosed. Each unit comprises: (a) an incoming channel with a cell capture site; (b) a cell culture chamber located posterior to the cell capture site, having a receiving site spaced apart from the cell capture site at a distance of g; (c) a trapping channel located between the cell capture site and the receiving site; (d) a chamber channel located posterior to and in fluidic connection with the cell culture chamber; and (e) a by-pass channel, located lateral to the incoming channel, chamber and chamber channel and having a first end and a second end opposite to the first end, the first end branching out from the incoming channel immediately prior to the cell capture site and the second end joining the chamber channel. A method of capturing single cells of more than one type is also disclosed.

A microfluidic detection chip for multi-channel rapid detection, including a chip body. A chip sampling port, a plurality of independent detection chambers, and a microfluidic channel are disposed on the chip body, and the chip sampling port is connected to the detection chambers by means of the microfluidic channel. The chip body further includes an electrode. The detection chambers are connected to the electrode. The microfluidic channel includes a main flow channel and a plurality of branching microfluidic channels. A tail end of the main flow channel is divided into the plurality of branching microfluidic channels, and the plurality of branching microfluidic channels are connected to the plurality of independent detection chambers in a one-to-one corresponding manner. And, the other end of the main flow channel is connected to the chip sampling port.

A rotary analysis apparatus and related methods are disclosed. The apparatus generally includes a rotary machine operable to rotate or spin a removable disk-type analytical cartridge. The cartridge includes a plurality of fluidly isolated processing trains for processing multiple samples simultaneously. Each process train includes an extractant mixing chamber, slurry filtration chamber, supernatant collection chamber, and reagent mixing chamber in fluid communication. In one use, soil sample slurry is prepared and added to the extractant mixing chamber. The slurry is mixed with an extractant by rotating the cartridge to separate out an analyte from the mixture. A sediment filter in the filtration chamber deliquifies and traps soil particles to produce clear supernatant. A color changing reagent or fluorescent agent may be mixed with the collected supernatant for subsequent colorimetric, fluorescent, turbidimetric, or other type of analysis.

An analysis container comprises a main body; a first chamber that is provided inside the main body and holds a liquid sample; a second chamber; a liquid passage; and an air passage. The liquid passage connects the first chamber and the second chamber, and moves the liquid sample from the first chamber to the second chamber. The air flow chamber connects the first chamber and the second chamber, and moves air from the second chamber to the first chamber.

Provided herein are a system and method for using a microfluidics device. The system includes: a plurality of pumps and a plurality of sensors; a first communication line to select a pump from the plurality of pumps and select a sensor from the plurality of sensors; a second communication line selectively connected to the selected pump; and a third communication line selectively connected to the selected sensor.

The present invention relates to the microfluidic sorting, separating and/or manipulation of particles, preferably circulating tumor cells (CTCs). In an aspect of the present invention, there is provided a device for sorting, separating or manipulating particles in a fluid suspension, the device comprising: (a) at least one inlet for introducing the fluid suspension; (b) at least one outlet for discharging the fluid suspension containing particles of a desired size; and (c) a channel in fluid communication with and intermediate the at least one inlet and the at least one outlet, a portion of the main channel is curved to form at least one curved unit, the curved unit is shaped to form a profile of a wave having a crest, a lip that curls over a trough, and a face, wherein the crest, lip, face and trough of the curved unit each forms a semicircular arc segment, the fluid suspension travels through the curved unit from the semicircular arc segment of the crest to the semicircular arc segment of the trough.