A chemical reactor is implemented on a substrate. The chemical reactor has multiple ducts for transporting a fluid and/or gas during use of the chemical reactor, in which the ducts optionally include pillar structures and at least one connection duct connected between two of the multiple ducts for transporting the fluid and/or gas from one duct to another. In the connection duct, a series of individual pillar structures are positioned behind each other in the longitudinal direction of the connection duct.

A fluidic processor device and a wafer including the same, the device including a nanofluidic separator chip including a nanoDLD array, a housing for housing the chip including a top plate disposed on a topside of the chip, a bottom plate disposed on a backside of the chip and fastened to the top plate, and a spacer disposed between the chip and the bottom plate to create a clearance between the chip and the bottom plate for forming a drain space on the backside of the chip.

The present invention provides microfluidic technology enabling rapid and economical manipulation of reactions on the femtoliter to microliter scale.

The present invention relates to a microfluidic impedance cytometer comprising an integrated biosensor and use of the device thereof for label-free activation profiling of cells in a sample, such as myelocytes and/or lymphocytes and neutrophils. The microfluidic impedance cytometer may comprise a spiral-shaped flow channel, coplanar electrodes for generating an electric field across the channel, a first sample inlet and a second sheath fluid inlet; wherein the sample inlet is a stepped sample inlet in that the height of the sample inlet is lower than the height of the sheath fluid inlet and the flow channel.

The describes example systems, devices, and techniques. In one example, a device includes a body extending away from a substrate, which includes a first end with an open-facing port configured to allow introduction of a tissue sample, and a second end that forms an open outlet proximal the major surface of the substrate. At least a portion of the body includes therein a tissue chamber for the tissue sample. At least one microfluidic channel on the major surface of the substrate is fluidly connected to the tissue chamber, and includes an inlet upstream of the tissue chamber and an outlet downstream of the tissue chamber. A separation element is between the tissue chamber and the at least one microfluidic channel. The tissue chamber, the separation element and the microfluidic channel occupy a single layer on the substrate.

Systems and methods for sorting T cells are disclosed. Autofluorescence data is acquired from individual cells. An activation value is computed using one or more autofluorescence endpoints as an input. The one or more autofluorescence endpoints includes NAD(P)H shortest fluorescence lifetime amplitude component (?.sub.1).

Selectively vented biological assay devices and methods of performing biological assays with such devices are provided herein. Disclosed devices include a selective venting element having passively tunable porosity. The methods include controlling fluid flow within the subject devices with the selective venting element.

A field portable diagnostic apparatus uses a rotatable disk in which a microfluidic circuit is defined. The microfluidic circuit includes a centrifugal separation chamber receiving a sample to stratify the sample. A magnetic bead holding chamber is communicated to a mixing chamber, where mass amplifying functionalized magnetic-nanoparticles, held in a buffer solution and contained in the magnetic bead holding reservoir communicated to mixing chamber, are mixed with the separated fluid delivered to mixing chamber from the separation chamber. The functionalized magnetic nanoparticles conjugate with a target analyte in the sample. A magnet in proximity to a SAW chamber including a SAW detector draws the functionalized magnetic nanoparticles toward antibodies immobilized on the SAW sensor surface A wash reservoir is communicated to the SAW sensor chamber, and a cleanup/waste reservoir is communicated to the SAW chamber for receive fluid after it has passed through the SAW chamber.

The present disclosure relates to devices and methods for the detection and/or sorting of nucleic acids. Further disclosed are methods for device fabrication.

The disclosure relates to devices and methods for analyzing particles in a sample. In various embodiments, the present disclosure provides devices and methods for cytometry and additional analysis. In various embodiments, the present disclosure provides a cartridge device and a reader instrument device, wherein the reader instrument device receives, operates, and/or actuates the cartridge device. In various embodiments, the present disclosure provides a method of using a device as disclosed herein for analyzing particles in a sample.