The present disclosure relates to a sample assessment device. By way of example, the sample assessment device may include a substrate including a sample application region; an amplification region comprising a plurality of amplification reagents; a waste region comprising an entrance fluidically coupled to the amplification region and extending away from the amplification region; and a detection region spaced apart from the amplification region. The sample assessment device may also include a valve coupled to the substrate and configured to separate the amplification region from the detection region in a closed configuration, wherein the amplification region and the valve are positioned on the sample assessment device between the sample application region and the detection region and wherein the sample assessment device is configured to permit lateral flow from the amplification region to the detection region when the valve is in an open configuration.

The present invention provides microfluidic devices capable of sequestering single particles in individual microchambers and isolating the particles from one another. The devices provide a plurality of channels fluidly connected to a plurality of microchambers. A fluid suspension comprising particles of interest can be passed through the devices in a first direction to sequester single particles in each microchamber. An isolating fluid can be passed through the devices in a second, reverse direction to isolate the particles from one another. The devices can selectively isolate several particles in each microchamber.

A reacting device of dual path synchronous immunochromatographic platform includes a seat, an upper housing, and a fluid dividing funnel. The seat contains two immunochromatographic carriers. The hollow pipe portion has two sloped structures. A force bearing portion of the fluid dividing funnel can be pressed down, so two fluid exits of the fluid dividing funnel move towards these two sloped structures. The specimen drops and is guided into these two immunochromatographic carriers respectively. A reaction result can be observable. The fluid dividing funnel can divide the specimen into two immunochromatographic carriers evenly. The sloped structure can increase the accuracy of specimen supply. Excess specimen can be scraped off for enhancing the solving accuracy. In addition, it can decrease the possibility of false positive problem.

Devices, systems and apparatuses for the discretization and manipulation of sample volumes are provided. Related methods are also provided.

Provided are a chip for separating or aligning fine particles, a device for separating or aligning fine particles including two or more chips for separating or aligning fine particles, and a method for separating or aligning fine particles using the chip for separating or aligning fine particles or the device for separating or aligning fine particles. The chip for separating or aligning fine particles includes: (i) a passage part in which a space where a fluid including fine particles which are capable of flowing is integrally formed and which has an inclined groove formed on one surface thereof; (ii) an inlet part which is positioned on one end of the passage part and into which the fluid is introduced; and (iii) a fine particle discharge part which is positioned on one side surface of the passage part, wherein one or more inclined grooves are formed to be inclined at an angle greater than 0° and less than 90° with respect to a line which is perpendicular to both side surfaces of the passage part.

A method of operating an electrowetting on dielectric (EWOD) device performs microfluidic diffusion separation. The method includes the steps of: inputting a sample droplet into the EWOD device, wherein the sample droplet includes a mixture of particles including first particles and second particles that are different from each other; inputting a collection droplet into the EWOD device; performing an electrowetting operation to bring the sample droplet into contact with the collection droplet; at an initial time, initiating a process of particle separation by which a portion of the sample droplet is introduced into the collection droplet, wherein the first particles move through the collection droplet at a rate different from the second particles; and after a time interval from the initial time, performing an electrowetting operation to segment a leaving droplet from the collection droplet, wherein the leaving droplet has a higher concentration of the first particles relative to the second particles as compared to a concentration of the first particles relative to the second particles in the sample droplet at the initial time. The method may be performed by an AM-EWOD control system executing program code stored on a non-transitory computer readable medium.

A trace metal analysis detector and method of operating the same to detect metals in various fluid samples using boron doped diamond working electrodes.

The invention provides multi-function instruments for automatically and simultaneously carrying out a variety of tests including identification of targets in specimens and antimicrobial susceptibility testing thereof. Application-specific cartridges are pre-loaded with all required reagents and allow for tests to be performed in a single testing device with no specimen preparation to, for example, rapidly detect infections, identify infectious pathogens, and analyze their susceptibility to various antimicrobial agents. Instruments include various stations for carrying out test steps that can be randomly accessed in any order dictated by the computer-controlled instrument. A carousel stores and incubates cartridges and, with a mechanical conveyor arm, transfers the cartridges between the required stations to carry out the tests. A plurality of different tests may be performed on a plurality of targets within an instrument, and the plurality of targets may be disposed in a single cartridge.

In one example in accordance with the present disclosure, a cellular analytic system is described. The cellular analytic system includes an analytic device. The analytic device includes a chamber to receive a cell to be analyzed. At least one lysing element agitates the cell and at least one sensor detects a change in the cell based on an agitation of the cell. The cellular analytic system also includes a controller to determine a rupture threshold of the cell based on parameters of the agitation when a cell membrane ruptures.

An automated system for preparing, detecting and analyzing a first fluid sample containing biological species, the preparation, detection and analysis system including at least one fluidic cartridge that includes at least one fluidic concentration and lysis module and one fluidic detection module including an array of several amplification chambers arranged in parallel, an apparatus including a mechanical assembly comprising at least one movable rod fastened to the frame and comprising a free end arranged to cooperate with a flexible membrane of the fluidic concentration and lysis module, an optical measurement system for measuring fluorescence through one or more amplification chambers of the fluidic detection module of the cartridge, a control and processing unit.