The present invention provides a test device for nucleic acid, including a sample treatment chamber, a sample reaction chamber and a test chamber which are disposed from top to bottom successively. The functions of sampling, nucleic acid purification, isothermal amplification and testing result reading by immunochromatography are integrated onto a device to prepare a simple and cute test device for nucleic acid; the device can achieve nucleic acid testing only by two rotations and can ensure that each sampling or reagent adding can reach the target area in a free falling way without any extra drainage facility. The present invention has lower costs, more convenient operation, high detection sensitivity, short time required in nucleic acid testing, and can be used for nucleic acid testing of various samples, such as human and animals.

Fluid storage containers and analysis cartridges for use in assay processes are presented. In addition, systems comprising such storage containers and analysis cartridges and methods of using such containers and cartridges are presented as well. In specific embodiments, fluid storage containers are configured to be coupled to analysis cartridges in a first stage and a second stage.

A microfluidic device can comprise at least one swept region that is fluidically connected to unswept regions. The fluidic connections between the swept region and the unswept regions can enable diffusion but substantially no flow of media between the swept region and the unswept regions. The capability of biological micro-objects to produce an analyte of interest can be assayed in such a microfluidic device. Biological micro-objects in sample material loaded into a microfluidic device can be selected for particular characteristics and disposed into unswept regions. The sample material can then be flowed out of the swept region and an assay material flowed into the swept region. Flows of medium in the swept region do not substantially affect the biological micro-objects in the unswept regions, but any analyte of interest produced by a biological micro-object can diffuse from an unswept region into the swept region, where the analyte can react with the assay material to produce a localized detectable reaction. Any such detected reactions can be analyzed to determine which, if any, of the biological micro-objects are producers of the analyte of interest.

There is provided a sample processing cartridge comprising a. a sample entry location; b. a closed sample processing chamber; c. a sample analysis location comprising a sample analysis well; d. a first channel fluidly connecting the sample entry location and the sample processing chamber; e. a second channel connecting the sample analysis location and the sample processing chamber, the second channel comprising a closed or closable second channel valve; wherein the sample processing chamber comprises a second channel port providing fluid connection between the second channel and the sample processing chamber, the second channel port being positioned in a sample accumulating region of the sample processing chamber. There is also provided a sample processing system comprising the cartridge, and methods of use of the cartridge and processing system in a sample processing assay.

A liquid refining apparatus is disclosed. The liquid refining apparatus includes a substrate, a loader which is formed on the substrate and configured to receive a first liquid, a filter which is configured to reduce a concentration of at least one substance contained in the first liquid to obtain a second liquid with a reduced concentration of the at least one substance, a reactor which is configured to mix the second liquid with a reactant for target substance detection to obtain a third liquid containing, among a plurality of substances contained in the second liquid, a first substance which undergoes a predetermined reaction with the reactant and a second substance which does not undergo the predetermined reaction with the reactant, and a separator which is configured to separate the first substance and the second substance.

A detection chip is disclosed. The detection chip includes a sample injection structure, a filter structure, and a reaction structure which are sequentially connected. The filter structure includes a first main body, and a first inlet portion and a first outlet portion respectively on two sides of the first main body. A width of the first inlet portion gradually decreases in a direction away from the first main body, and a width of the first outlet portion gradually decreases in a direction away from the first main body.

A method for filling microchambers with a chemistry in a substrate containing a plurality of microchambers comprises forming a channel in the substrate such that the channel is fluidically connected with the plurality of microchambers. The chemistry is delivered into the channel so that the chemistry is delivered to each of the microchambers. The chemistry is then permitted to incubate within each of the microchambers. Excess chemistry is then removed from the microchambers by introducing fluid through the channel to each of the connected microchambers.

A system for collecting a sample of a liquid, the system including a liquid storage vessel including an opening, and a capping element configured to seal the opening of the storage vessel is provided. The capping element includes a chamber configured to store a sample of the liquid separate to the liquid storage vessel. The capping element includes a pipette element defining the chamber that is configured to store the sample of liquid taken from the storage vessel.

A system configured to determine the load in a liquid sample of predetermined antigens is provided. The system comprises a measurement chamber configured for receipt therein of the liquid sample, a sensor circuit, and an analysis unit. The sensor circuit comprises a plurality of working electrodes, each comprising antibodies on its surface associated with one of the predetermined antigens, at least one reference electrode, and at least one counter electrode. Proximal ends of the electrodes are disposed on a reading zone of the sensor circuit, the reading zone being disposed within the measurement chamber. The analysis unit is configured to facilitate the determination of the load of each of the antigens by measuring electrical properties of the electrodes.

A tissue handling system includes a biopsy device and a tissue storage container separate from the biopsy device. The biopsy device has a cutting cannula, a housing, and a tissue collecting device. The tissue collecting device is detachably received in the housing. The tissue collecting device is configured to receive at least one tissue sample. The tissue storage container is configured to detachably receive the tissue collecting device after the tissue collecting device is disengaged from the housing of the biopsy device to deliver the at least one tissue sample from the tissue collecting device to the tissue storage container.