A reaction processing vessel includes a substrate and a groove-like channel formed on the upper surface of the substrate. The channel includes a high temperature serpiginous channel, a medium temperature serpiginous channel, and a high temperature braking channel and a medium temperature braking channel that are adjacent to the high temperature serpiginous channel and the medium temperature serpiginous channel, respectively. The respective cross-sectional areas of the high temperature braking channel and the medium temperature braking channel are larger than the respective cross-sectional areas of the high temperature serpiginous channel and the medium temperature serpiginous channel, respectively.

A modular fluid chip according to an embodiment of the present disclosure includes a body including at least one first hole which allows fluid to flow therethrough; and a housing receiving the body therein, and including a second hole which corresponds to the at least one first hole and allows the fluid to flow therethrough, and a fluid connection part which is connectable to another modular fluid chip.

There is disclosed a capillary microfluidic circuit including a main channel communicating with a flow inducing element. The main channel has intermediary inlets. Reservoirs for containing one or more liquids prior to being drawn into the main channel. The reservoirs include a first reservoir and at least a second reservoir. Each of the reservoirs has an upstream end connectable to vents for filling the reservoirs with the one or more liquids and a downstream end. The downstream end of each of the reservoirs is connected to the intermediary inlets of the main channel A conduit is disposed between the first reservoir and the a least a second reservoir. The conduit links the downstream end of the first reservoir with the upstream end of the at least a second reservoir.

A microchannel chip (1) includes: a first channel (201); a reagent holder (230); a gas inlet (210) communicating with the first channel; a lid (50) closing the gas inlet; and a second channel (202) provided downstream of the first channel. A specimen holder (240) is provided downstream of the reagent holder (230). When the lid (50) closes the gas inlet (210), gas is supplied to the first channel (201) and pushes out the reagent downstream from the reagent holder (230). Thus, the pushed-out reagent merges with a specimen in the second channel (202).

In a flow path device, a first groove, a second groove and a third groove are provided. The first groove is connected to and continuous with a first hole. The second groove is connected to and continuous with the first groove. The third groove is connected to and continuous with the second groove. The third groove is connected to the second groove at a position on the second groove spaced from the first groove. The first groove extends toward a position opposite to the second groove with respect to the first hole. The second groove and the third groove define a first minor angle adjacent to the first hole and define a second minor angle opposite to the first hole. The first minor angle is larger than the second minor angle.

Described herein is a microfluidic chip comprising a first channel in fluid communication with an adjacent second channel through a opening, wherein the height of the first channel and the second channel are chosen to generate sufficient surface tension at the opening such that a liquid injected into the first channel or the second channel is substantially confined within the first channel or the second channel, respectively, or that flow of the liquid therebetween is controlled, the surface tension producing a non-physical microfluidic barrier that limits or selectively controls passage of the liquid. Also described are in vitro microphysiological systems that use such microfluidic chips in modeling the structure and functions of human organs, such as a blood-brain barrier, and studying in vivo-like physiological responses of such organs to various investigative or therapeutic agents.

Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.

Provided herein are magnetofluidic cartridges of use in a wide variety of sample analysis applications, including nucleic acid amplification assays. The magnetofluidic cartridges include sample inlet wells and sample analysis wells. Temperature sensitive materials are used to separate the sample inlet wells and sample analysis wells from one another prior to performing a given sample analysis application. Related magnetofluidic devices, kits, and methods are also provided.

A method for multiplying DNA includes using a rotation device to rotate a sample carrier about an axis of rotation. The sample carrier has at least one cavity in which a sample liquid containing DNA is received. The cavity is heated to a high temperature value only on a heat input side lying in a rotation plane by using a heating device. As a result of the heating, a convection current is created in the sample liquid in the cavity, the convection current having substantial current components directed perpendicularly to the rotation plane. A circulation time of a liquid particle along a current path of the convection current is predetermined by the speed of the rotation. A rotation device for multiplying DNA and a system for multiplying DNA, are also provided.

The present invention relates to a microfluidic device (100) for mixing liquids, wherein the microfluidic device (100) comprises a plurality of device inlets (110), each device inlet (110) for receiving a liquid; a chamber assembly (120) comprising a set of chamber inlets (122) in fluid communication with the device inlets (110); a mixing chamber (124) for receiving the liquids through the chamber inlets (122); and a plurality of chamber outlets (126) for communicating the liquids away from the mixing chamber (124); and a set of device outlets (130) in fluid communication with the chamber outlets (126), wherein the chamber outlets (126) are spaced around the mixing chamber (124) such that the mixing chamber (124) facilitates uniform mixing of the liquids communicating from the chamber inlets (122) to the chamber outlets (126). The invention also relates to a method of additive manufacturing a product comprising the microfluidic device as well as a liquid control system for controlling liquids in a microfluidic device.