The present disclosure is related to a method of producing a microfluidic sorting apparatus. The method includes providing an injection-molded substrate comprising a network of channels; bonding an insulating film to an upper surface of the substrate to cover the network of channels; and depositing a conductive film on the insulating film. The substrate can be separated from the conductive film.

The present invention discloses a microstructured discrimination device for separating hydrophobic-hydrophilic fluidic composites comprising particulate and/or fluids in a fluid flow. The discrimination is the result of surface energy gradients obtained by physically varying a textured surface and/or by varying surface chemical properties, both of which are spatially graded. Such surfaces discriminate and spatially separate particulate and/or fluids without external energy input. The device of the present invention comprises a platform having bifurcating microchannels arranged radially. The lumenal surfaces of the microchannels may have a surface energy gradient created by varying the periodicity of hierarchically arranged microstructures along a dimension. The surface energy gradient is varied in two regions. In one pre-bifurcation region the surface energy gradient generates a fluid flow. In the other post-bifurcation region, there is a difference in surface energy proximal to the bifurcation such that different flow fractions are divided into separate channels in response to different surface energy gradients in each of the post-bifurcation channels. Accordingly, fluids of different hydrophobicity and/or particulate of different hydrophobicity are driven into separate channels by a global minimization of the fluid system energy.

A fluidic device for capturing or detecting a sample substance contained in a solution includes at least two continuous circulation flow channels selected from the group consisting of: a first type continuous circulation flow channel which is formed of a first circulation flow channel and a second circulation flow channel and which is configured to circulate the solution in the first circulation flow channel and then circulate the solution in the second circulation flow channel; and a second type continuous circulation flow channel which is formed of a third circulation flow channel and a fourth circulation flow channel and which is configured to circulate the solution in the third circulation flow channel and then circulate and mix the solution in both of the third and fourth circulation flow channels, wherein any one of the circulation flow channels has a capturing section which captures the sample substance, and/or a detecting section which detects the sample substance.

The invention relates to a substrate for testing samples, in particular cells or molecules, wherein the substrate comprises a fluid system comprising a sample chamber configured in the substrate for storing and testing samples and at least one liquid reservoir in fluid communication with the sample chamber, and wherein the substrate comprises a passive blocking element capable of assuming a closed position and an open position, wherein in the closed position a fluid exchange between the sample chamber and the liquid reservoir is blocked.

A microfluidic device, a microfluidic detection assembly and a detection method for the microfluidic device. The microfluidic device includes a first substrate and a second substrate; the first substrate and the second substrate are oppositely arranged to define a channel between the first substrate and the second substrate, the channel is configured for liquid to flow, the first substrate includes a base substrate and a plurality of control assemblies which are arranged on the base substrate along an extending direction of the channel, each of the plurality of control assemblies includes: a first electrode, a second electrode and a plurality of coils, and the first electrode is configured to input currents into the plurality of coils, and the plurality of coils are connected in parallel to the second electrode.

A device and system for detecting aldehydes or ketones and, more particularly, a device and system, for detecting aldehydes or ketones, utilized in a rotating platform are provided.

An example device with a microfluidic channel for use in a chamber is provided, the example device comprising: a chamber to contain a fluid; a microfluidic channel located internal to the chamber, the microfluidic channel having an entrance within the chamber and an exit within the chamber, the microfluidic channel defined by a housing located within the chamber; a unidirectional displacement mechanism inside the microfluidic channel, the unidirectional displacement mechanism located between the entrance and the exit; and a controller to activate the unidirectional displacement mechanism to cause the fluid from the chamber to enter the microfluidic channel via the entrance and leave the microfluidic channel via the exit thereby agitating the fluid within the chamber, the fluid otherwise being non-moving.

A microfluidic device for analysing nucleic acids includes a pump unit with a pumping volume, a filter unit for receiving a lysate, and a reaction chamber. The pump unit, the filter unit and the reaction chamber are arranged in the stated order in a pump direction of the pump unit. The microfluidic device is configured to pump an elution medium via the pump unit into the filter unit for elution and subsequently into the reaction chamber for further treatment.

The present invention relates to the field of micro fluidics. Specifically, the present invention relates to a novel flow cell for the selective enrichment of target particles or cells from a fluid. The flow cell exhibits a novel design which greatly improves the target particle or cell yield. The invention also provides a micro fluidic device, comprising the flow cell according to the invention. In another aspect, the invention relates to the use of a flow cell or a micro fluidic device of the invention for the isolation of target particles or cells from a fluid sample. Finally, the invention relates to a method for the selective enrichment of target particles or cells from a fluid using the flow cell of the invention.

The present invention is directed to a recirculation system for use in microfluidic centrifugal disc platforms for reusing and mixing an entire sample. The present invention features a system comprising a reservoir, an input channel, a detection array, a pressure chamber, and a recirculation channel connecting the pressure chamber to the reservoir. The recirculation channel may have a resistance lower than the channel upstream resistance. When the CD platform spins at a high RPM, the liquid may be directed from the reservoir into the pressure chamber. When the RPM of the CD platform decreases rapidly, the liquid may be from the pressure chamber through the channel and through the recirculation channel to the reservoir, such that the liquid travels through the recirculation channel faster than the liquid travels through the channel.