A method of manufacturing a component having a flow path, wherein the method includes forming a high pressure resistant casing with a cavity therein, inserting a body of bioinert material into the cavity to thereby form a composite block, and further processing the composite block for at least partially forming the flow path defined by the component.

Methods and devices for detecting a low concentration analyte in a sample are provided herein. The methods include flowing a sample through a porous membrane coated with a capture matrix to capture the low concentration analyte. The methods also can include detecting the captured analyte, such as by performing in-situ amplification of the analyte.

A structural reinforcement and biocompatible pump head for a pump includes a reinforcement structure having a plurality of ports and fluid pathways therein. The fluid pathways in the reinforcement may be coated or lined with a biocompatible material to form a biocompatible pump head useful for liquid chromatography and other analytical instrument systems. The biocompatible material may be injection molded into the fluid pathways of the reinforcement structure and may be machined after core pins are removed to obtain a desired surface finish and/or size of the biocompatible fluid pathways of the pump head.

A container (1) for storing a bodily fluid, for example a blood collection tube (2), comprising: an interior space (4) configured to store the bodily fluid; and a wall (5) enveloping the interior space, wherein a surface of the wall (5) facing the interior space (4) of the container (1) forms a contact surface (6), wherein at least a portion of the contact surface (6) is provided with a primer coating (7), wherein the primer coating (7) is formed from a perfluorophenyl azide (PFPA) including an azide group (9) and a functional group (10), and wherein a co polymer made from poly (N-vinylamine-co-N-vinyl acetamide) is bonded to the functional group (10) of the primer coating (7). The invention also relates to a method for coating a contact surface (6) of a container (1) for storing a bodily fluid.

A flow cell can comprise a first substrate; a second substrate; and/or an adhesive layer that couples the first substrate to the second substrate. The adhesive layer can comprise a first adhesive and a second adhesive. A flow channel can be at least partially defined by the first substrate on a flow channel first side, by the second substrate on a flow channel second side opposite the flow channel first side, and by the first adhesive between the first substrate and the second substrate. The first adhesive can be disposed between the flow channel and the second adhesive.

The invention provides reduced background substrates, such as multi-well plates, for use in enzyme-linked immunosorbent assays (ELISAs) and other ligand-binding assays, and methods for making and using the same.

System and method includes a body having a central microchannel separated by one or more porous membranes. The membranes are configured to divide the central microchannel into a two or more parallel central microchannels, wherein one or more first fluids are applied through the first central microchannel and one or more second fluids are applied through the second or more central microchannels. The surfaces of each porous membrane can be coated with cell adhesive molecules to support the attachment of cells and promote their organization into tissues on the upper and lower surface of the membrane. The pores may be large enough to only permit exchange of gases and small chemicals, or to permit migration and transchannel passage of large proteins and whole living cells. Fluid pressure, flow and channel geometry also may be varied to apply a desired mechanical force to one or both tissue layers.

Described are systems and methods for multi-material printing. The systems and methods can utilize a stereolithographic printing device, a moving stage, and a microfluidic device. The microfluidic device can include a plurality of reservoirs, each reservoir housing a different ink for printing, and a microfluidic chip. The microfluidic chip can include a chamber that comprises a plurality of inlets, a printing region, and one or more outlets as well as an elastic membrane.

Described herein are systems and methods for analyzing biological samples. Including a method for processing an analyte, comprising providing a fluidic device comprising the analyte and one or more polymer precursors; selecting a discrete area within said fluidic device; providing an energy source in optical communication with fluidic device; and selectively supplying a unit of energy generated from the energy source to the fluidic device to generate a polymer matrix within the fluidic device, wherein the polymer matrix is within the discrete area or adjacent to the discrete area.

The disclosure relates to a microfluidic control chip. The microfluidic control chip may include an upper cover, a lower cover, and a chip functional layer between the upper cover and the lower cover. The chip functional layer may include a first region. The chip functional layer in the first region may include at least one chamber unit, an inlet flow channel to the chamber unit, and an outlet flow channel from the chamber unit. The chamber unit may include a main flow channel, a plurality of secondary flow channels, and a plurality of microcavity structures. The chamber unit may be configured to allow a liquid to flow from the main flow channel to the plurality of secondary flow channels, and then to the plurality of microcavity structures.