B01L2300/1816

System and method for rapid multiplexed sample processing with applications for nucleic acid amplification assays

The invention(s) cover systems and methods for target detection in a multiplexed and rapid manner. Embodiments of the system can include: a base substrate; and an array of sample processing regions defined at a broad surface of the base substrate, wherein each of the array of sample processing regions includes: a set of microwell subarrays arranged in a gradient by volumetric capacity between an upstream end and a downstream end of each respective sample processing region, and a boundary separating each respective sample processing region from adjacent sample processing regions. The system can support methods, with example implementation by an automated platform, for returning preliminary results from a subset of microwells of the samples processing regions, as well as results pertaining to specific and non-specific amplification, for multiple targets of a sample.

DEVICES AND METHODS FOR RAPID PCR

Instruments, methods, and kits are disclosed for performing fast thermocycling.

APPLICATIONS USING INDUCTION
20180318569 · 2018-11-08 ·

A system and method comprise positioning a medical device within a subject. The medical device includes a plurality of compartments and each of the plurality of compartments includes a ferrous material. Further, each of the plurality of compartments is configured to hold a substance. The system and method further include delivering electromagnetic radiation, by an electromagnetic radiation source, to the medical device and varying, by a controller, an amount of the electromagnetic radiation delivered by the electromagnetic radiation source for selectively heating the ferrous material of at least one of the plurality of compartments and selectively releasing the substance held in the at least one of the plurality of compartments for managing a condition.

FLEXIBLE CONVERTIBLE HOTPLATE ADAPTER FOR ROUNDED VESSELS AND OBJECTS
20180288831 · 2018-10-04 ·

The present invention is an article or device to facilitate the heating of rounded vessels and other rounded objects comprising a flexible polymeric support comprising a plurality of nested, concentric hollow cylindrical portions each having respective upper edges and adapted to be arranged and fixed in at least two configurations such that the upper edges of the concentric hollow cylindrical portions accommodate at least two respective bowl-shaped contours. The present invention also includes a device to facilitate the heating of rounded vessels or objects, or regularly-shaped or irregularly-shaped objects and containers comprising a container presenting a flexible polymeric support surface, the container containing a malleable material, such that said flexible polymeric support surface is sufficiently malleable so as to be adapted for the heating such objects or containers. Also included is an arrangement for heating such a container or object, and/or for stirring the contents of such a container, while being supported by the article or device of the present invention.

TEMPERATURE-CONTROLLED FLUIDIC REACTIONS SYSTEM
20240293818 · 2024-09-05 ·

The present disclosure discloses methods and systems for executing chemical reactions including a source reservoir, an input channel in fluid communication with the source reservoir and a main channel. The input channel is configured to distribute a reaction volume from the source reservoir into a main channel. The main channel includes a plurality of pads on an inner surface of the main channel configured to convey the reaction volume as a plurality of droplets via electro wetting. The system includes a destination reservoir configured to receive the plurality of droplets from the main channel into a pool.

FLOW CONTROL AND PROCESSING CARTRIDGE
20180250668 · 2018-09-06 ·

A flow control and processing cartridge used in a nucleic acid analysis apparatus includes a cartridge body and a reaction chip. The cartridge body includes plural chambers for storing at least one sample and plural biochemical reagents and buffers, and plural channels connected with the plural chambers. The reaction chip is in conjunction with the cartridge body and includes plural detection wells, at least one main fluid channel connected with the detection wells and adapted to dispense the sample into the detection wells, and at least one gas releasing channel connected with the detection wells and adapted to release gas from the detection wells.

Device for incubating a sample

The field of the invention relates to a device for incubating a sample. The present disclosure provides an incubator for shaking and/or heating at least one sample. The device comprises at least one inductor placed below an induction heating plate. A heat conducting plate is mounted onto the induction heating plate. The device further comprises a moving arrangement for placing the sample onto the heat conducting plate.

COMPACT OPTICAL SYSTEM FOR SUBSTANIALLY SIMULTANEOUS MONITORING OF SAMPLES IN A SAMPLE ARRAY

Optical systems and apparatuses configured for enabling substantially simultaneous observation of a plurality of points in an array from a common reference point. Without the optical systems and apparatuses disclosed herein, less than all of the plurality of points can be observed substantially simultaneously from the common reference point.

METHOD FOR QUALITATIVE AND/OR QUANTITATIVE DETECTION OF SUBSTANCES CONTAINED IN A HEMP PLANT AND KIT FOR USE THEREIN
20240345107 · 2024-10-17 ·

A method for qualitatively and/or quantitatively detecting one or more substances contained in the hemp plant using a kit having a) an ampoule; b) a material comprising a hemp plant or parts thereof; and c) a color indicator capable of reacting by contacting the hemp plant and/or at least a part thereof to change the color of the color indicator, wherein the material and the color indicator are disposed in the ampoule.

DEVICE, INSTRUMENT, AND METHOD FOR INDUCTIVE HEATING OF A SAMPLE FOR ANALYTE DETECTION

Induction heating can be used facilitate reactions within biological samples. A sample container can be placed in a magnetic field from an induction coil to generate heat. An exemplary sample container can include an electrically insulative outer wall surrounding an interior space for containing a biological sample and a heating element within the interior space, the heating element comprising an electrically conductive portion. In use, the sample container can be received within a receptacle that includes the induction coil. The induction coil is operated to induce a current in the heating element of the sample container until the biological sample reaches a target temperature.