A laboratory sample/specimen temperature control device, specifically a metal bead bath that has its metal bead temperature controlled by a continuous flow of air into the bed of beads that is heated or cooled by a Peltier device that the air flows over. This provides great thermal uniformity across the bed of beads and constantly monitors and regulates the heat or cooling input rather than utilizing an on/off modulation temperature input approach.

According to one embodiment, a reagent storage include a placement table, a housing, a cover, and a fan. The placement table on which a plurality of reagent containers are placed. The housing configured to contain the placement table. The cover having a probe hole through which a probe is inserted and configured to cover an opening of the housing. The fan configured to send air in a first space defined by an inner bottom of the housing and the placement table into a second space defined by the cover and the placement table and to exhaust the air in the second space through the probe hole.

The technology described herein generally relates to microfluidic cartridges configured to amplify and detect polynucleotides extracted from multiple biological samples in parallel. The technology includes a microfluidic substrate, comprising: a plurality of sample lanes, wherein each of the plurality of sample lanes comprises a microfluidic network having, in fluid communication with one another: an inlet; a first valve and a second valve; a first channel leading from the inlet, via the first valve, to a reaction chamber; and a second channel leading from the reaction chamber, via the second valve, to a vent.

A Polymerase Chain Reaction (PCR) device used to detect infectious agents and certain diseases. The device provides a quantitative PCR that amplifies the target DNA sequence, while monitoring the amplitude of signal originating from DNA-intercalating probes, typically fluorescence, to quantify the amount of DNA being amplified. The device is used in combination with other medical devices to obtain the user's physical exam data. A combination of the PCR machine and above-mentioned other instruments with a network communication device (TOTUS) sends the physical exam and PCR information to servers, and/or physicians, pharmacists and other medical professionals to provide AI decisions.

There is provided a cool box for use in an automatic analyzer. The cool box has a box body and an air circulator. The box body has a receiving space capable of accommodating therein receptacles for analytes or reagents. The circulator has an intake portion, a fan, and an exhaust portion and operates to circulate air in the receiving space by rotation of the fan. The circulator further includes an inhibitor removing agent retaining portion on which a pouch is set. The pouch contains an analysis inhibitor removing agent for removing components (analysis inhibitor) which adversely affect or inhibit analysis of the analytes.

A generic point of care based portable device and method thereof as a platform technology for detecting pathogenic infection via nucleic acid based testing achieving sample-to-result integration, comprising the following interconnected stand-alone modules: a thermal unit for executing piece-wise isothermal reactions in a pre-programmable concomitant fashion without necessitating in-between operative intervention; a colorimetric detection unit seamlessly interfaced with smartphone-app based analytics for detecting the target analyte. The said platform technology is thus capable of detecting targeted pathogen-associated RNA by coupling additional complementary DNA probe hybridization combined with isothermal reaction purposed for reverse transcription of RNA followed by amplification of the resulting c-DNA as well as subsequent specific binding of the same in a single user-step in a concomitant fashion and its smartphone-enabled interpretation, in a generic modular format that renders operative suitability outside controlled laboratory environment in a user-friendly manner, with predictive accuracy favorably comparable with gold standard RT-PCR tests.

A hand-held molecular diagnostic test device includes a housing, an amplification (or PCR) module, and a detection module. The amplification module is configured to receive an input sample, and defines a reaction volume. The amplification module includes a heater such that the amplification module can perform a polymerase chain reaction (PCR) on the input sample. The detection module is configured to receive an output from the amplification module and a reagent formulated to produce a signal that indicates a presence of a target amplicon within the input sample. The amplification module and the detection module are integrated within the housing.

An insulated chamber having an interior region for storing items therein includes a phase change material to facilitate controlling the temperature of the interior region and the items. A heating device or cooling device may be used to melt or freeze the phase change material. The phase change material (PCM) may be in various locations such as the walls of the chamber in the form of packets or in the form of containers that serve as shelves and may be removable from the interior region. The packets may have recesses for receiving the items. The phase change material may be within capsules that may be within a liquid or a solid matrix. Controls may be provided to control humidity, oxygen, and carbon dioxide within the interior chamber.

Fluidic device includes a manifold body having first and second body sides. The first body side has receiving ports forming a port array that defines a reaction region. The second body side has open-sided recesses forming reaction chambers when the fluidic device is mounted onto a sample substrate. The reaction chambers form a chamber array that defines a fluid-delivery region. The reaction region is greater than the fluid-delivery region. The manifold body also includes vent openings that open to an exterior. The fluidic device also includes upstream channels extending through the manifold body. Each of the upstream channels fluidly couples a corresponding receiving port of the port array to a corresponding reaction chamber of the chamber array. The fluidic device also includes venting channels extending through the manifold body. Each of the venting channels fluidly couples a corresponding reaction chamber of the chamber array to a corresponding vent opening.

In a reaction or growth monitoring system, the temperature of a reaction vessel is controlled using heat from a semiconductor sensor placed in direct or thermal contact with the reaction vessel. The heat from the semiconductor sensor is controlled by monitoring the temperature at the reaction vessel and by controlling accordingly, the operation of the sensor and/or by controlling a cooling mechanism in thermal contact with the semiconductor sensor. Additional heat may be provided to the reaction vessel via electromagnetic radiation from an electromagnetic illumination source.