A diagnostic device (1) for detecting a first member of a reporter-analyte pair. The diagnostic device comprises an inlet for receiving a liquid, biological sample and a porous membrane element (10) comprising a detection portion. The detection portion is in liquid communication with the inlet and a second member of the reporter-analyte pair is immobilised on the detection portion. One of the first or second member of the reporter-analyte pair comprises a biological antigen and the other of the first or second member of the reporter-analyte pair comprises an antibody specific for the biological antigen. The biological antigen comprises a spike protein, or a fragment thereof, of COVID-19. The device is for independent detection of the spike protein, or the fragment thereof, or of an antibody specific for the spike protein, or the fragment thereof, in the biological sample.

A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.

A microstructured surface is disclosed capable of immobilizing or resisting displacement forces with respect to a target surface. The microstructured surface is capable of generating capillary bridges with a target surface. The capillary bridges can be further stabilized to generate a novel liquid enhanced adhesion mechanism.

Provided herein are systems and methods for a point of care apparatus. The point of care apparatus includes a fluid container for receiving a biosample, an intermediate cap, and a cartridge having at least one microfluidic channel.

The disclosed apparatus, systems and methods relate to devices, systems and methods for the collection of bodily fluids. The collector can make use of microfluidic networks connected to collection sites on the skin of a subject to gather and shuttle blood into a removable cartridge. The collected fluid is supplied to substrate for drying, storage and transport.

An exemplary blood sampling device can be provided that can collect a small amount of blood and prevent blood leakage. The exemplary blood sampling device can comprise a pipette tip-shaped blood sampler having an internal space for aspirating and holding blood by the capillary action and having openings at the top and bottom, a cylindrical container capable of accommodating the blood sampler and a cap piston-shaped sealing cap for sealing the container, wherein a receiving part is provided at the bottom of the container and a locking part and a screw part are provided on the upper outer side of the container, and a mandrel extending from the inner upper surface of the sealing cap is provided and a projection and a screw part are provided on the inner side surface of the sealing cap.

The present disclosure provides a cell harvesting method for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology.

The invention relates to a testing device with a testing assembly for lateral flow assay. The testing assembly comprises liquid sample receiving interface arranged on a support structure defining a plane. The liquid sample receiving interface is configured to receive a liquid sample. The testing assembly comprises at least one testing strip fluidly connected to the liquid sample receiving interface. The testing strip comprises a capillary wick fluidly connected to the liquid sample receiving interface and including at least one test portion, the test portion comprising at least one respective reacting material configured for reacting in a predetermined manner to at least one specific analyte. The testing device comprises an optical sensor, arranged and configured for detecting light reflected from the at least one test portion and for converting the detected light into an electrical signal representing an intensity and/or a color of the detected light. The testing device further comprises a conversion unit for converting the electrical signal into digital data representing the intensity and/or the color of the detected light, and a transmitter unit for wirelessly transmitting digital data.

A micropump for exchanging liquid between a supply region and a working region is provided. An enclosed gas region is located above the working region. The micropump includes a capillary pipette having a closed pipette tip on a first end, an open pipette inlet disposed opposite the first end, and a pipette section enclosing the working region and disposed in a direction of the open pipette inlet from the closed pipette tip. The micropump further includes a liquid-permeable filter covering the open pipette inlet and connected to the supply region. The micropump additionally includes a capillary structure extending through the gas region between the closed pipette tip and the liquid-permeable filter.

Methods and systems for capture object-based assays, including for determining a measure of the concentration of an analyte molecule or particle in a fluid sample, are described. The methods and systems may relate to high sensitivity detection of analytes, sometimes using assay conditions and sample handling that result in the capture and detection of a high percentage of the analyte molecules or particles in a fluid sample using relatively few capture objects. Apparatuses and methods for immobilizing capture objects with respect to assay sites, in some instances with unexpectedly high efficiencies are also described. Some such apparatuses involve the use of force fields and fluid meniscus forces, alone or in combination, to facilitate or improve capture object immobilization. Also described are techniques for utilizing a relatively high percentage of capture objects in an assay sample, such as by using disclosed sample washing techniques, imaging systems, and analysis procedures that can reduce capture object loss.