The present invention relates to methods of conducting cholinesterase inhibition assays. In one instance, the assays can be configured to determine the presence of inactivated and activated cholinesterases. Also described herein are microfluidic devices and systems for conducting such assays.

A rotor assembly includes a rotor plate to rotate around a first axis, a bucket attached to the rotor plate and to rotate around a second axis, and a stop plate to rotate around the first axis between an open position and a closed position. When in the closed position, the stop plate engages the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly. The rotor assembly further includes a housing for a sensor array component, the housing disposed in the bucket and including a solution inlet, a solution outlet, a transfer basin, a solution retainer disposed between the solution outlet and the transfer basin, and a collection reservoir in fluid communication with the transfer basin. The solution inlet and the solution outlet to engage ports of a flow cell of a sensor array.

A device for separating and recovering blood fractions includes two conical chambers communicating via their bases, the first chamber having a duct for supplying the fluid to be treated and means for recovering at least one component, the second chamber comprising an elastically deformable flexible membrane that transversely separates a space opening into the duct for communicating with the second chamber, and a bag having a volume that varies according to the deformation of the membrane.

The present invention discloses a kind of centrifugal detection channel, including: a first chamber, at least one inlet channel, at least one buffer valve, at least one outlet channel, and a second chamber. Specifically, at least one inlet channel is connected to the first chamber. At least one buffer valve is connected to the inlet channel, including: a valve body and a transient chamber. At least one outlet channel is connected to the buffer valve. At least one second chamber is connected to the outlet channel. In addition, the detection devices and the detection methods comprising the centrifugal detection channel have also been proposed.

A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.

A method of performing an optical measurement of an analyte in a processed biological sample using a cartridge is provided. The cartridge is operable for being spun around a rotational axis. The method comprises: placing the biological sample into a sample inlet; controlling the rotational rate of the cartridge to process a biological sample into the processed biological sample using a fluidic structure; controlling the rotational rate of the cartridge to allow the processed biological sample to flow from the measurement structure inlet to an absorbent structure via a chromatographic membrane, and performing an optical measurement of a detection zone on the chromatographic membrane with an optical instrument. An inlet air baffle reduces evaporation of the processed biological sample from the chromatographic membrane during rotation of the cartridge.

Provided are a cupping device and a blood analysis apparatus using the same. The cupping device includes a cupping cup having a first opening defined in a lower portion thereof, at least one blood collecting container disposed adjacent to an outer surface of the cupping cup and having an accommodation space configured to accommodate blood therein, and a connecting pipe disposed between the cupping cup and the blood collecting container to connect an inner space of the cupping cup to the accommodation space of the blood collecting container.

The present invention addresses the problem of providing a centrifugal smearing device and a sealed rotating container in which liquid components do not leak to an outside of the sealed rotating container. To solve this problem, in a centrifugal smearing device (30) including a sealed rotating container (34) that houses a chamber (10) with a slide glass removably attached for holding the liquid sample to smear cells in the liquid sample with a centrifugal force onto the slide glass, and a base (31) housing the sealed rotating container (34) and including rotational driving means (32) for rotating the sealed rotating container (34), the sealed rotating container (34) includes a main body (40) capable of housing the chamber (10) and a lid (42) for closing an upper surface opening portion of the main body (40), and has a storage section (46) for storing liquid scattered from the chamber (10) during being centrifuged, formed on an inside face of the main body (40).

Accordingly, in some embodiments of the disclosure, a multi-chambered assay device is provided, which is configured for arrangement on a disc, as well as configured to process an individual sample. A plurality of such assay devices can be arranged along a periphery of the disc at a distance/radius from the center, such that a plurality of individual samples can be processed, e.g., one per assay device. In addition, in an arrangement that a plurality of assay devices are used, they can be spaced apart such that they balance the disc during rotation (which can be with samples contained in one or more of the assay devices, a plurality, a majority, or all of the assay devices).

An assay plate is provided. The assay plate has a body with a plurality of reservoirs formed therein. The reservoirs are shaped and aligned in the body in an orientation to induce drainage of fluids contained therein in a desired direction. A plate array and a funnel array forming an assembly for pooling of samples contained in the assay plate is also provided.