A reagent bottle cleaning device is provided, comprising a base, a cleaning assembly, and a cleaning block. The cleaning assembly comprises a pushing cylinder and a mounting plate. A plurality of mounting grooves are disposed on the mounting plate. Each mounting groove is provided with a cleaning motor. The cleaning motor is provided with a cleaning screw rod. The cleaning block is provided with cleaning grooves corresponding to the cleaning screw rods. Injecting pumps are disposed between the cleaning block and the cleaning assembly. The injecting pumps are connected to the base by lifting cylinders. Full-automatic quick cleaning of reagent bottles can be realized under the effect of a main control chip.

System for performing a flow-based assay. The system may comprise a droplet generator to produce an emulsion including droplets in a carrier fluid. The system also may comprise a thermocycler including two or more temperature-controlled zones and also including a channel connected to the droplet generator for receiving the emulsion. The channel may form a single-pass continuous fluid route traversing the temperature-controlled zones multiple times, such that droplets passing through the channel are thermally cycled. The system further may comprise a detection station downstream from the thermocycler and configured to detect a signal from the droplets after such droplets have been thermally cycled by passing through the channel.

Embodiments of the invention related to dispensing devices (100), and more particularly to dispensing devices having a dropper or dispenser (200) associated with a container (900) full of product wherein the dropper (200) may be charged, separated from the container (900), and then used to dispense a product therefrom.

Described are exemplary embodiments of a handheld, powered positive displacement pipette having unique mechanisms for the retention, identification and ejection of associated pipette syringes.

A fluidic device (1) configured to drive movement of fluid under centrifugal force comprises a central region about a central rotational axis (X) of the device and a peripheral region extending radially outwards from the central region. A fluid reservoir (4) provided in the central region of the device receives a fluid sample and communicates with at least one fluidic system (6), which extends radially outwards from the fluid reservoir (4) into the peripheral region of the device. Each fluidic system (6) comprises a fluid analysis chamber (12) configured to retain a portion of a fluid sample for analysis. A fluidic channel arrangement (26) is configured to enable fluid communication between the fluid reservoir (4) and the fluid analysis chamber (12), and movement of the fluid sample through the fluidic channel arrangement is driven by the centrifugal force created by rotational motion of the device about the central rotational axis (X). A valve mechanism (8) is arranged between the fluid reservoir (4) and the analysis chamber (12) and is configured to prevent fluid flow through that portion of the fluidic channel arrangement (26) when the speed of rotation of the device is less than a predetermined value. A cut-out portion of the device (24) may help to correctly locate the fluidic device (1) within an assay apparatus. An apparatus for driving rotational motion of the fluidic device and a method for moving a fluid sample within the fluidic device are also described.

The present invention is directed to methods, compositions and devices useful for the detection and/or quantification of a microbial contaminant, including an endotoxin. In embodiments, cartridges are provided that suitably include dried compositions that are useful in absorbance-based assays and in combination with portable readers/devices.

A method for detecting an analyte includes first to third steps. The first step is distributing a sample containing a bead modified with a host molecule that is specifically bound to the analyte in a microchannel using a syringe pump. The second step is irradiating the sample with non-resonant light that is light outside a wavelength range of electronic resonance of the bead. The third step is detecting the analyte based on a signal from a camera that receives the light from the sample.

An apparatus, multi-well plate and method for automated cell lysis and nucleic acid purification and amplification. The plate includes a lysis well, at least one wash well, an elution well, and a PCR chip. The apparatus includes a vertically aligned rotor mixer comprising a magnetic tip and actuators for moving the rotor mixer in a vertical and horizontal directions, to transfer magnetic beads from well to well. The rotor mixer is used to vortex lysis mixtures, wherein the vortexing speed is sufficient to overcome the magnetic attraction between the beads and mixer tip and disperse the beads in solution, to collect nucleic acids such as DNA in an elution solution that is transferred to the PCR chip for amplification of target sequences.

A particle detection device is provided. The particle detection device may include a substrate and at least one detection unit setting on the substrate. The at least one detection unit may include: a detection pool, configured to accommodate a sample liquid; a sample injection part communicating the detection pool, the sample injection part being sealable with a liquid driving device, wherein the liquid driving device and the sample injection part cooperate to enable the sample liquid to get in and out of the detection pool

A device to detect pathogens and/or analytes in a test sample is designed to include a core, which may have first and second chambers. The first chamber is designed to accept a combination of a test specimen and a buffer liquid. A piston is designed to slideably engage into the first chamber of the core, wherein the end of the piston may engage with the bottom of the first chamber and be capable of grinding the test specimen. A plunger is designed to slideably engage with the second chamber of the core, and is in fluid communication with the first chamber. An assay section is attached to the core, and is in fluid communication with the second chamber. The assay device is designed to include a test strip that is capable of detecting and indicating the presence of pathogens and/or analytes in the combination of the test sample and buffer liquid.