A cylinder-and-piston assembly for a bottle attachment apparatus for handling liquids provides a cylinder attachable to a valve block assembly, a piston, displaceable in a sealed manner in the longitudinal direction within the cylinder, and a cylinder housing connected to the piston and externally encompassing the cylinder. The piston is displaceable in the cylinder and the stroke length of the piston in the cylinder is delimited by a fixed stop, which interacts with a stroke length stop on the cylinder housing. The cylinder housing has a longitudinal slot running in the longitudinal direction and on the external side thereof has a scale assigned to this longitudinal slot. The stroke length stop on the cylinder housing is adjustable in the longitudinal direction and is interlockable in the respective position.

A suction tip includes a tip opening, a tubular passage provided with a first selector configured to permit the passage of non-selection subjects included in a collection of subjects sucked through the tip opening, and a capture portion provided on a side of the tubular passage downstream of the first selector in a suction direction of the collection of subjects and configured to capture the non-selection subjects. The capture portion includes a passage hole configured to permit the passage of the non-selection subjects and a storage portion configured to store the non-selection subjects having passed through.

A method and an apparatus for characterizing a fluid provide for flowing a sample fluid through a microfluidic flow line in a first direction and into contact with a microfluidic sensor, measuring a property of the fluid sample using the microfluidic sensor; and after measuring the property of the fluid sample, flushing the microfluidic sensor by flowing a solvent through the microfluidic flow line in a second direction that is opposite the first direction.

Various embodiments provide a connector for the sterile transfer of a liquid medium from a container to a bioprocess engineering system. The connector has two coupling devices. The coupling devices each have a housing and a control element which is adjustably mounted in the housing interior and forms a channel. The channel extends from a control element inlet opening to a control element outlet opening. The housings are able to be mechanically connected to one another and have a fluid inlet and a fluid outlet. The fluid outlet of one housing and the fluid inlet of the other housing overlap. The control elements are each adjustable from a starting position, into an operating position, in which the control element inlet opening is fluidically connected to the fluid inlet and the control element outlet opening is fluidically connected to the fluid outlet.

An active fluid component (40) for connection with a substrate (10) has an interface which can be connected with the substrate (10) in a fluid-tight manner, and a magnet (42) arranged in the region of the interface.

A cartridge module comprising a cartridge receptacle configured to receive and hold a cartridge that comprises a plurality of chambers and fluidic channels and a plurality of valves for regulating fluid flow to and from the chambers via the fluidic channels; a manifold configured to engage a first side of the cartridge and thereby bring the chambers in fluidic communication with a source of positive pressure or negative pressure; and a plurality of springs configured to actuate a thermocycling device.

A collection system configured to maintain the integrity of a bodily fluid sample has a proximal end portion, a distal end portion, and an inner surface defining a fluid flow path therethrough. The distal end portion is configured to be placed in fluid communication with a patient. The proximal end portion is configured to be placed in fluid communication with a fluid reservoir. The fluid flow path defined by the inner surface is associated with at least one flow characteristic configured to limit a stress within the flow of the bodily fluid between the distal end portion and the proximal end portion.

The invention relates to a substrate for testing samples, in particular cells or molecules, wherein the substrate comprises a fluid system comprising a sample chamber configured in the substrate for storing and testing samples and at least one liquid reservoir in fluid communication with the sample chamber, and wherein the substrate comprises a passive blocking element capable of assuming a closed position and an open position, wherein in the closed position a fluid exchange between the sample chamber and the liquid reservoir is blocked.

Systems and methods that enable automated processing of specimens carried on microscope slides are described herein. Aspects of the technology are directed, for example, to automated specimen processing systems configured to use microfluidic slide processing modules to robotically process tissue specimens. The slide processing modules can include reagents and a flow cell with a reaction chamber for holding the tissue specimens and reagent.

The present disclosure provides for devices for preparing a sample for nucleic acid detection, methods of detection of a nucleic acid in a sample, system for preparing and analyzing nucleic acid, and the like. The present disclosure provides for an on-site testing device, system, and method for pathogen detection in water. The device, system, and method can process large sample volumes using a paper-based sample preparation method, amplify DNA using loop-mediated isothermal amplification (LAMP) or amplify RNA using reverse transcription LAMP (RT-LAMP), and detect amplicons based on color change or other signals.