An integrated testing device and fluid module are disclosed, as well as a method of manufacture. Fluid module contains a reservoir containing a test fluid, and a control vessel. The reservoir discharges test fluid into the control vessel, which discharges the test fluid in a controlled way to a test component.

The invention provides devices that improve tests for detecting specific cellular, viral, and molecular targets in clinical, industrial, or environmental samples. The invention permits efficient detection of individual microscopic targets at low magnification for highly sensitive testing. The invention does not require washing steps and thus allows sensitive and specific detection while simplifying manual operation and lowering costs and complexity in automated operation. In short, the invention provides devices that can deliver rapid, accurate, and quantitative, easy-to-use, and cost-effective tests.

The present disclosure provides systems, methods, devices, and kits for analysis of vaginal biological samples. A device for the analysis of vaginal biological samples can include a sample collector, an extractor, and an assay cartridge. A method for the analysis of vaginal biological samples can include detecting the presence or absence of a pathology, a disease, an immune disorder, a reproductive disorder of a subject. The method may further comprise preserving, storing, or transporting the vaginal biological samples. A kit for the analysis of vaginal biological samples can include probe, reagents and instructions for detecting a nucleic acid in the vaginal biological samples.

A fluidic device (1) configured to drive movement of fluid under centrifugal force comprises a central region about a central rotational axis (X) of the device and a peripheral region extending radially outwards from the central region. A fluid reservoir (4) provided in the central region of the device receives a fluid sample and communicates with at least one fluidic system (6), which extends radially outwards from the fluid reservoir (4) into the peripheral region of the device. Each fluidic system (6) comprises a fluid analysis chamber (12) configured to retain a portion of a fluid sample for analysis. A fluidic channel arrangement (26) is configured to enable fluid communication between the fluid reservoir (4) and the fluid analysis chamber (12), and movement of the fluid sample through the fluidic channel arrangement is driven by the centrifugal force created by rotational motion of the device about the central rotational axis (X). A valve mechanism (8) is arranged between the fluid reservoir (4) and the analysis chamber (12) and is configured to prevent fluid flow through that portion of the fluidic channel arrangement (26) when the speed of rotation of the device is less than a predetermined value. A cut-out portion of the device (24) may help to correctly locate the fluidic device (1) within an assay apparatus. An apparatus for driving rotational motion of the fluidic device and a method for moving a fluid sample within the fluidic device are also described.

The present application discloses an antigenic detector, including: a pen holder and a pen cap. The pen holder includes: a test paper tube, a test paper assembled in the test paper tube, a test paper support, and a foam support installed on the front end of the test paper tube with a foam and a protective cover; the pen cap includes: a base, an aluminum foil assembled in the base, and an interior of the base forms a cavity into which a front end of the pen holder is inserted, and a reaction solution is sealed inside the cavity of the base by the aluminum foil; the protective cover is detachably installed on the front end of the test paper tube and covers the foam; the foam support is provided with a channel that communicates with an interior of the test paper tube.

An inspection chip includes: a body part including a microchannel; and a liquid introduction part introducing liquid into the microchannel. The liquid introduction part includes: a liquid reception part; and a lid part capable of sealing the liquid reception part. The liquid reception part includes: a liquid storage part having an opening part in an upper part thereof; and a connection part connected to the microchannel from a bottom part of the liquid storage part. The lid part includes a protrusion part that protrudes so as to be housed in the liquid storage part.

A biological sample reaction vessel comprising a reagent storage portion and a push rod movable relative to the reagent storage portion is provided. The reagent storage portion comprises at least one reagent containing cavity, and the reagent containing cavity is sealed by a sealing element; and the push rod is connected to the sealing element, and the push rod is used for cooperation with an external device to separate the sealing element from the reagent storage portion. In reaction, the biological sample reaction vessel cooperates with a test cassette. By inserting the biological sample reaction vessel into the external device, the reagent in the reagent storage portion can be released rapidly.

A cartridge has a strip that is provided with the test region and a case in which the strip is accommodated and in which an observation window for observing the test region from an outside is formed in a surface. A emission end portion, through which illumination light for illuminating a test region, is disposed at a position separated from the observation window on a rear surface of the case. A detection unit, that optically detects the color development state of the test region irradiated with the illumination light, is disposed at a position facing the observation window on a surface side of the case. The illumination light is transmitted from the rear surface of the case to an inside of the case, reaches the test region while being diffuse-reflected by an inner surface of the case, and illuminates the test region from the surface side.

Described herein are various embodiments directed to rotor devices, systems, and kits. Embodiments of rotors disclosed herein may be used to characterize one or more analytes of a fluid. An apparatus may include a first layer being substantially transparent. A second layer may be coupled to the first layer. The second layer may be substantially absorbent to infrared radiation. The second layer and the first layer may collectively define a set of wells. The first layer may define a base for each well of the set of wells. The second layer may define an opening for each well of the set of wells. At least one of the first layer and the second layer may define a sidewall for each well of the set of wells.

A device to detect pathogens and/or analytes in a test sample is designed to include a core, which may have first and second chambers. The first chamber is designed to accept a combination of a test specimen and a buffer liquid. A piston is designed to slideably engage into the first chamber of the core, wherein the end of the piston may engage with the bottom of the first chamber and be capable of grinding the test specimen. A plunger is designed to slideably engage with the second chamber of the core, and is in fluid communication with the first chamber. An assay section is attached to the core, and is in fluid communication with the second chamber. The assay device is designed to include a test strip that is capable of detecting and indicating the presence of pathogens and/or analytes in the combination of the test sample and buffer liquid.