A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.

In a centrifuge having a rotor with a rotor body that holds a sample and that is rapidly rotated, an inclined surface that extends upward as it extends radially outward is formed on an upper-side outer peripheral portion of the rotor, in a region that is at a radially outward side and at an upper side of the outer edge of an opening. The inclined surface is a continuous ring-like inclined surface that has the same cross-sectional shape in the circumferential direction and is formed into a straight-line shape or a curved-line shape in cross-section along a rotation central axis. Although winds occur during high-speed rotation of the rotor, the winds are rectified by the inclined surface, and a component force for pressing the rotor body in a downward direction acts thereon.

A centrifuge calibration apparatus (10) configured to be spun in a centrifuge and to provide an indication (25) of performance of the centrifuge. Spinning of the apparatus in the centrifuge causes a piston (14) to exert centrifugal force to compress a spring (22), thereby generating relative movement between a pointer (24) and a scale (26). The scale may be calibrated in units of G-force or RPM. A ratchet mechanism (40) holds the pointer at its most displaced position upon completion of the spinning and removal of the apparatus from the centrifuge.

A centrifuge calibration apparatus (10) configured to be spun in a centrifuge and to provide an indication (25) of performance of the centrifuge. Spinning of the apparatus in the centrifuge causes a piston (14) to exert centrifugal force to compress a spring (22), thereby generating relative movement between a pointer (24) and a scale (26). The scale may be calibrated in units of G-force or RPM. A ratchet mechanism (40) holds the pointer at its most displaced position upon completion of the spinning and removal of the apparatus from the centrifuge.

Compositions and methods for separating a sample of whole blood or bone marrow aspirate into a fraction rich in at least one of platelets and pluripotent cells are provided. A sample of whole blood can be centrifuged in a collection tube comprising a separator substance formulated to settle between the PRP fraction and the at least one other fraction. Preferably, centrifugation is completed without substantial activation of platelets. Optionally, the separator substance could be hardened to form a solid barrier that allows removal of all or substantially all of the platelets in the PRP fraction without remixing of the PRP fraction with the at least one other fraction. Transfer devices and methods are also provided in which a sterile sample can be transferred from a separation/preparation container (e.g., vacutainer) to a consumer or other container (e.g., dropper) while maintaining sterility of the sample.

The present invention relates to a high speed shatterproof contamination proof refrigerated centrifuge for cell extraction, comprising a housing, a central console disposed inside a chamber of the housing, a refrigerating mechanism disposed inside the housing, a separation mechanism, a pair of roll wheels disposed at a bottom of the housing and a shatterproof recollection device; a ring shaped working sink for installing the separation mechanism is disposed at a top wall of the housing; a ventilation hole and a control panel is disposed at two sides of the housing respectively; the separation mechanism comprises a centrifuge rotor disposed inside the ring shaped working sink and a rotational motor for driving the centrifuge rotor. The high speed shatterproof contamination proof refrigerated centrifuge for cell extraction of the present invention has the advantages of having a simple structure, sensible design, high rotational speed, and having refrigerating, angle adjustment and shatterproof recollection features. The high speed refrigerating centrifuge can also satisfy a higher requirement of material separation, refinement and purification.

A fixed angle centrifuge rotor includes a rotor body having a circumferential sidewall and a plurality of circumferentially spaced tubular cavities. An annular containment groove is disposed above and circumferentially surrounds the tubular cavities. Each tubular cavity has an open end and a closed end, and is configured to receive a sample container therein. The rotor further includes a pressure plate operatively coupled to the rotor body so that the pressure plate, in combination with the plurality of tubular cavities and the circumferential sidewall of the rotor body, define a hollow chamber within the rotor. The pressure plate includes circumferentially spaced upstanding tabs that are received in respective pockets located between adjacent tubular cavities. The rotor further includes a plurality of elongated torque transfer members supported by the rotor body. Each of the plurality of torque transfer members has a first end located between a respective pair of adjacent tubular cavities, and extends radially inward in a direction toward a rotational axis of the rotor.

There can be provided a tube rack of a centrifugal separator, in which a bottom rubber portion can be readily mounted and readily replaced, and yet such bottom rubber portion cannot be easily separated. The tube rack includes a holder (14) including a plurality of tube holes (12) each configured to accommodate a tube that is used for a sample and each includes an opening at one end portion of the holder serving as a tube insertion side, and an opening at a bottom portion of the holder that is at the other end. The tube rack includes a bottom rubber portion (15) including a plurality of bottom rubber members (25) each fits in the tube hole (12), and including connecting pieces (24). The tube rack includes a base (13) formed in a cylindrical shape having a bottom configured to accommodate and detachably hold the holder (14) and the bottom rubber portion (15), and to be inserted into a bucket of the centrifugal separator.

A sample processing unit (SPU)-equipped drone for transporting and processing biological materials and method of using same is disclosed. In some embodiments, the presently disclosed SPU-equipped drone and method provide a drone equipped to carry an SPU and wherein the SPU may include a centrifuge arranged inside a temperature-controlled chamber and wherein the centrifuge may be used to process biological materials at the same time that the SPU-equipped drone is in flight. Further, a method of using the presently disclosed SPU-equipped drone for transporting and processing biological materials is provided.

Apparatus and methods for separating blood components are disclosed in which an apparatus for separating blood generally includes a tube defining a channel and configured for receiving a quantity of blood and a float contained within the tube and having a density which is predefined so that the float is maintained at equilibrium between a first layer formed from a first fractional component of the blood and a second layer formed from a second fractional component of the blood. Upon completion of the centrifugation, the first layer may be removed from the tube while the float isolates the second layer from the first layer.