A device for separating blood into a plurality of blood components by centrifugal force includes a first chamber for receiving a blood bag filled with blood to be separated. Each separated blood component is located in a separate portion of the blood bag according to its specific weight. A second chamber receives at least one component bag to be filled with a blood component. The component bag has an inlet opening connected to an outlet opening of the blood bag by a line that has a controllable valve. A displacement body in the first chamber exerts a pressing force onto the blood bag. A control unit opens the valve until a blood component passes into the component bag as a result of the pressing force. The displacement body generates the pressing force with the aid of the centrifugal force and/or with the aid of a spring force.

The present invention provides an automated system and method to isolate nucleated blood cells from whole blood or bone marrow. A disc mounted to a centrifuge system with spinning rotor is used to manipulate cells by channeling fluids while subjected to high gravitational field. The disc embodies at least two axisymmetric processing stations connected by a circular channel. Each station contains multiple chambers connected by fluidic channels to controllably transfer fluids. First stage separation allows for the isolation of the buffy coat layer while the second stage separation utilizes gradient density fluids to isolate the targeted nucleated cells from the buffy coat layer in the spinning disc.

A blood bag system includes a PPP bag and a liquid drug bag which are accommodated adjacent to each other in pockets of a centrifugal drum of a centrifugal transport device. In addition, the blood bag system includes a retaining portion that retains the PPP bag and the liquid drug bag together, and includes a cassette accommodated in the pockets in a retaining state of the retaining portion. The cassette has a detachment mechanism capable of detaching at least the PPP bag.

A blood bag system is provided with a PPP bag that is accommodated in a PPP bag pocket, and a liquid drug bag that is accommodated in a liquid drug bag pocket provided adjacent to the PPP bag pocket. The PPP bag includes a first internal space and a seal part that seals the periphery of the first internal space. The liquid drug bag includes a second internal space and a seal part that seals the periphery of the second internal space. A connection part that separably connects the seal part and the seal part is provided there between.

A blood bag system includes a blood bag having a storage space for storing blood, a first tube that is connected to the blood bag and has a first flow path for communicating with the storage space, and a sealing member that is provided in the first tube and opens the first flow path by a breaking action. The first tube includes, at a position near the sealing member, an engagement portion for engaging with a centrifugal transport device with the sealing member disposed at the position where the breaking action is performed.

Disclosed is a centrifugal separation chamber (100) rotatable about an axis (AR) and having a variable volume separation space (116) therewithin and a port (102) in fluid communication with the volume for filling and emptying the volume, the chamber including a relatively rigid portion (104) proximal to the port which has walls defining a part of the volume and arranged to provide reducing dimensions of the volume toward the port, the chamber further including a flexible portion (106) distal to the port for providing said variable volume, the flexible portion including a mechanical interface (110) for transmitting movement to the flexible portion to cause said variable volume.

A vial and system are configured to simplify fluid input and extraction therefrom. The vial has a first end opposite a second end and with a collapsible sidewall. The sidewall can be collapsed, such as by imparting a differential pressure between an interior and exterior of the vial, for simplified fluid extraction and smooth extraction without disturbing boundaries between separated components. The vial typically has a bulb at a first end and a neck extending away from the bulb and toward the second end. An inlet spaced from the first end can be configured to attach to various different interfaces or processing elements for input and output of fluids. A support cup can be provided for use with the vial during centrifugation to allow the vial to withstand any centrifugation forces. Various fluid processing methodologies are supported by the collapsible vial, especially including methods of separation of components of blood.

An insert (10) for a rotor (14), which rotates about a rotor axis (12), of a centrifuge (16) incorporating a housing (30) having at least one container for bags, in particular blood bags, that comprises a slider (66) that cooperates with a drive, a rotatable spindle nut (62) and a spindle (64), wherein the spindle nut (62) is rotatably mounted in the housing (30) and connected to the drive, and the spindle (64) is translationally slidably mounted in the spindle nut (62) and connected to the slider (66). The slider (66) is arranged in the container and acts on the bag in a predetermined manner. The spindle (64) moves between a starting position and an operating position, wherein the spindle nut (62) is rotatably mounted in the housing (30) via at least one bearing (60). The bearing (60) is formed by a lubricant-free bearing (60) having an outer bearing ring in contact with the housing and a bearing ring in contact with the spindle nut (62).

A modular cassette is provided for separating a composite fluid into at least two component parts thereof during centrifugation. The modular cassette includes: a housing defining a fluid inlet, a fluid outlet, and a chamber for fluid separation; a fluidic channel configured to provide fluid communication between at least two components of the modular cassette; a heat expanding valve including: a flow pathway including undulations configured to facilitate closing of the fluidic channel, wherein the heat expanding valve occludes one or more of the undulations of the flow pathway to close the fluidic channel; and a heating element configured to actuate the heat expanding valve.

A system for the processing and separation of biological fluids into components comprises an apparatus that cooperates with a disposable set, comprising a cabinet (100) for housing a hollow centrifugal processing chamber (20) of the disposable set. The cabinet comprises a plurality of side-by-side locations (110) for receiving a corresponding plurality of centrifugal processing chambers (20) in side-by-side spaced-apart relation. Each location comprises an individual drive means (52) for driving its centrifugal processing chamber. Remotely-actuable valves (124) associated with the disposable sets are located on the apparatus' cabinet in the proximity of said locations. Valve actuation provides a display of the state of actuation of the valves (124). Selection of this state of actuation is arranged to control connection of the centrifugal processing chamber (20) of each fitted disposable set with a flexible container (200) of the same disposable set or another container, and to control connection of the centrifugal processing chambers (20) with flexible containers of the same or other fitted disposable sets in different combinations, in particular with series and/or parallel connections.