A biological component collection system and a circuit internal pressure acquisition method are provided, which are capable of accurately measuring the circuit internal pressure. A centrifugal separation device of a blood component collection system comprises an estimated data calculation unit that calculates estimated data B on the basis of initial data A, and a correction unit that corrects the estimated data B in a manner so that the internal pressure calculated by a first internal pressure calculation unit becomes equivalent to the internal pressure calculated by a second internal pressure calculation unit.

A centrifugal separation device of a blood component collection system comprises a data acquisition unit that acquires initial data A, an estimated data calculation unit that calculates estimated data B on the basis of the initial data A, a reaction force calculation unit which calculates a reaction force of a first applied load measurement unit on the basis of the estimated data B, and an internal pressure calculation unit that calculates an internal pressure of the first applied load measurement unit, based on the reaction force and a load detected by a first load detecting unit.

Embodiments of a system box for holding a bag system and methods for separating composite liquids are described. In embodiments, a bag system may be a blood bag system used to collect blood, separate the blood into components, store the components, and utilize the components in patients. The system box may hold the blood bag system. Processes can then be performed to separate components from the blood.

Embodiments of a system box for holding a bag system and methods for separating composite liquids are described. In embodiments, a bag system may be a blood bag system used to collect blood, separate the blood into components, store the components, and utilize the components in patients. The system box may hold the blood bag system. Processes can then be performed to separate components from the blood.

A clip of the present application generally comprises a first clip member, a second clip member, and a retention feature. The first clip member and the second clip member are coupled together and capable of being placed in at least two positions. In the first position, the clip is capable of receiving a bag containing a fluid, and, in the second position, the bag is capable of being held between the first and second clip members. While the clip is holding the bag, two or more pockets are formed in the bag, and the fluid is generally restricted or prohibited from transferring from one pocket to another pocket while the clip is in this position. A retention feature retains the clip, which is holding a bag, to a centrifuge receptacle and allows the clip to be placed in a predetermined position on the centrifuge receptacle.

A blood component collection system (10) includes a first internal pressure calculation unit (110) adapted to calculate a first internal pressure of a first pressed portion (60) using first calibration curve data (118), a second internal pressure calculation unit (112) adapted to calculate a second internal pressure of a second pressed portion (62) using second calibration curve data (120), and a correction unit (114) adapted to correct the first calibration curve data (118) in a manner so that the first internal pressure becomes equal to the second internal pressure in a state in which operation of a collection and returning pump (100) is stopped during at least one of a collection operation and a returning operation of a first cycle.

A blood component collection system (10) includes a first internal pressure calculation unit (110) adapted to calculate a first internal pressure of a first pressed portion (60) using first calibration curve data (118), a second internal pressure calculation unit (112) adapted to calculate a second internal pressure of a second pressed portion (62) using second calibration curve data (120), and a correction unit (114) adapted to correct the first calibration curve data (118) in a manner so that, during a blood returning operation, the first internal pressure calculated by the first internal pressure calculation unit (110) becomes equal to the second internal pressure calculated by the second internal pressure calculation unit (112).

A separation rotor having an outer wall defining a separation chamber and an inner annular wall dividing the separation chamber into an inner annular space and an outer annular space. The separation rotor can be rotated to move heavier and/or denser components of the multi-component fluid into the outer annular space. The lighter and/or less dense components of the multi-component fluid can be retained within the inner annular space. The inner annular space and the outer annular space separation rotor can be selectively accessed to withdraw the components retained within the inner annular space and the outer annular spaces.

A method for separating a biological suspension includes dispensing a liquid suspension comprised of cells or microorganisms from a bioreactor or fermenter into a sterile compartment of a first bag assembly, the first bag assembly including a collapsible bag having of one or more sheets of flexible film. The compartment of the first bag assembly is sealed closed. The first bag assembly, either with or without a manifold fluid coupled therewith, is then rotated, such as by using a centrifuge, so that the liquid suspension separates within the compartment into a pellet comprised of the cells or microorganisms and a liquid supernatant.

A centrifuge (70) is provided with a cup (80) configured to house a blood bag system (10a) and centrifugally separates blood in the blood bag system (10a) by rotating the cup (80). The cup (80) has a segment holding section (86) capable of holding a plurality of segment tubes (44a), aligned in a parallel state by being folded at a sealing portion (44b) of an outlet-side tube (44), along a direction in which a centrifugal force acts during centrifugal processing or a direction inclined with respect to the direction in which the centrifugal force acts.