Systems and methods are provided for fabricating microneedle arrays that includes electrospun fibers preferentially disposed within the microneedles of the array. Providing the electrospun fibers preferentially in the microneedles allows for more of a drug or other substance present in the fibers to be deposited into tissue or to provide other benefits. A mold for forming the microneedle arrays includes an insulating surface layer. The insulating surface layer affects the electric field during electrospinning such that electrospun fibers are deposited preferentially within the microneedle cavities of the mold relative to the surface of the mold. A bulk material can then be applied to the mold to form the bulk of the microneedles with electrospun fibers embedded within and a backing layer to which the microneedles are attached.

Impact-dissipating liners, helmets having an impact-dissipating liner, and methods of fabricating impact-dissipating liners are provided. The liners include a fluid impermeable enclosure having cavities with sidewalls and a fluid contained in the enclosure. The enclosure may have a central portion and lobes extending from the central portion, wherein the central portion and the lobes are adapted to conform to the shape of an internal surface of a helmet. The helmets may include bodies positioned within the cavities of the liner, where, under impact loading, contact between the bodies and the liner absorbs at least some of the energy of the impact loading. Aspects of the invention are particularly adapted for use for head protection, such as, helmets; however, aspects of the invention are also adaptable to provide impact-dissipation for any body or surface that would benefit from such protection.

A method and a device for manufacturing dissolving microneedle, wherein the method comprises manufacturing a mold with a plurality of microporous cavities, and manufacturing a polymer solution to be sprayed into the microporous cavity by a high pressure spraying device to enable the sprayed solution to fill in each microporous cavity. After the dryness of the solution, a microneedle is extracted from the mold. The process for manufacturing the microneedle is without vacuum pumping or any load of centrifugal force, and the process is simple and the excellent rate is high.

Devices, systems, and methods appropriate for use in medical training that include materials that better mimic natural human tissue are disclosed. In one aspect, multi-layer tissue simulations are provided. In another aspect, male genitalia models are provided. In another aspect, abdominal surgical wall inserts are provided. Systems and methods associated with these devices are also provided.

The method comprises the following steps: (a) supplying at least one cosmetic material and supplying at least one photoactivatable material; (b) forming a layer (19) comprising on at least a first region of the layer (19), a photoactivatable material supplied in step (a); (c) illuminating at least the first region of the layer (19) to activate the photoactivatable material; (d) forming an additional layer (19) on at least a second region of the additional layer (19), a photoactivatable material supplied in step (a), (e) illuminating at least the second region of the additional layer (19) to activate the photoactivatable material; (f) repeating steps (d) to (e) until the three-dimensional object is formed.
The cosmetic composition comprised in the three-dimensional object or forming the three-dimensional object being recoverable after the three-dimensional object is formed.

Microneedle arrays and methods of forming the same can include one or more bioactive components bonded to a biocompatible material such that the one or more bioactive components are cleavable in vivo to release the bioactive component from the biocompatible material.

Devices, systems, and methods appropriate for use in medical training that include materials that better mimic natural human tissue are disclosed. In one aspect, multi-layer tissue simulations are provided. In another aspect, male genitalia models are provided. In another aspect, abdominal surgical wall inserts are provided. Systems and methods associated with these devices are also provided.

This invention designs and builds multiple layers (two layers or more) of millable dental blocks or disks for milling of various dental devices, specifically denture base blocks or disks of denture base material, where milled teeth cavities to receive artificial denture tooth materials to form final dental devices, such as partial and full dentures. This invention also designs and builds multiple layers (two layers or more) of millable denture base or denture blocks or disks comprised of denture base or/and denture tooth materials to form final dental devices, such as partial and full dentures. A method for manufacturing a layered denture is provided. The invention provides a multiple layered denture base block (or disk) for milling a denture base. The invention also provides a multiple layered denture block (or disk) for milling a denture. Highly shape adjustable or shape memory polymer layer(s) may be used in these multiple layered forms. Different layer of material has different mechanical and physical properties to meet different need, which provide added benefits to the patients, dental professional and dental laboratory.

A barrier wall is formed by rotating a mold to a horizontal orientation so that a rear wall of the mold is horizontally disposed and an encircling sidewall upstands from the rear wall, the floor and encircling sidewall at least partially bounding a compartment, an upper end of the encircling sidewall at least partially bounding a first access opening to the compartment. A first material is disposed into the compartment through the first access opening, at least a portion of the material being curable. A cover is placed over the first access opening to enclose the compartment. The mold is then rotated from the horizontal orientation to a vertical orientation. A portion of the sidewall is then moved to form a second access opening to the compartment. A second material is then dispensed into the compartment, at least a portion of the second material being curable.

The present disclosure relates to insulation systems. The teachings thereof may be embodied in an insulation system for an electrical machine. For example, an insulation system may comprise: solid insulation materials; an impregnating resin having oxirane functionalities; a depot accelerator distributed throughout the solid insulation materials; and a catalyst for initiating hardening of the impregnating resin, wherein the catalyst is at least partly in gaseous form under hardening conditions.