Various examples are provided related to polyurethane spray foam and its application. In one example, a method includes providing a system including a polyurethane spray foam (SPF) raw material supply, a fluid handling system, an air source, a heated hose, a whip hose, and a metal stray gun. Each of part A and part B material streams, either or both of which include particles, are generated by the system and conveyed by the system through the system and into a disposable mixing nozzle engaged with the metal stray gun. A mixture of the part A and part B material streams can be applied, via the disposable mixing nozzle, to a surface or into a mold at a pressure of 250 psi or less. A polyurethane spray foam coating generated from the method can be applied at a thickness of from about 0.5 inches to about 12 inches.

A transdermal drug delivery patch according to an exemplary embodiment of the present invention includes: a flexible base layer; and a plurality of microneedle disposed at one surface of the base layer. Each of the plurality of microneedles includes a biodegradable polymer and a drug and has an empty space inside. Each of the plurality of microneedles is formed as a star-shaped pyramid including a plurality of protrusions extending in a radial direction, and a part between two protrusions adjacent along the circumferential direction among the plurality of protrusions is concave.

The present invention is directed to a method of making at least a portion of a garment that includes at least one three-dimensional contour. The disclosed method includes providing a fiber and solvent mixture that includes fibers and a solvent capable to causing a plurality of covalent bonds to be created between the fibers. In many embodiments, the plurality of covalent bonds form when a catalyst, such as heat, is provided to the fiber and solvent mixture. The process can be performed using, for example, either a 3D printer or mold form. The fibers used can be natural, synthetic, or a blend of natural and/or synthetic fibers. The solvent preferably includes ionic salts in water.

The present invention is directed to a method of making at least a portion of a garment that includes at least one three-dimensional contour. The disclosed method includes providing a fiber and solvent mixture that includes fibers and a solvent capable to causing a plurality of covalent bonds to be created between the fibers. In many embodiments, the plurality of covalent bonds form when a catalyst, such as heat, is provided to the fiber and solvent mixture. The process can be performed using, for example, either a 3D printer or mold form. The fibers used can be natural, synthetic, or a blend of natural and/or synthetic fibers. The solvent preferably includes ionic salts in water.

A catheter for ablating tissue is provided. The catheter comprises an elongated generally-tubular catheter body having proximal and distal ends. An electrode assembly is provided at the distal end of the catheter body. The electrode assembly including a porous electrode arrangement that is generally transverse to the catheter body. The porous electrode arrangement comprises one or more electrodes electrically connected to a suitable energy source and a porous sleeve mounted in surrounding relation to the one or more electrodes and defining an open space between the porous sleeve and the one more electrodes. One or more irrigation openings fluidly connect the open space to a lumen extending through the catheter through which fluid can pass. In use, fluid passes through the lumen in the catheter, through the one or more irrigation openings, into the open space and through the porous sleeve.

The three-dimensional printing apparatus includes a tank, a platform, a lighting module, a control unit, a photosensitizer coating unit, and an exposure and development unit. The tank is filled with a liquid forming material, and the platform is movably disposed above the tank. The lighting module is used for providing light projecting toward the liquid forming material. The control unit coupled to the platform and the lighting module is configured to control the platform to move along a first direction, such that at least one layer object of a three-dimensional object is cured on the platform by layer. The photosensitizer coating unit is coupled to the control unit and configured to form at least one photosensitizer film on the layer object. The exposure and development unit is coupled to the control unit and configured to expose the photosensitizer film by exposing and developing to color the three-dimensional object.

The three-dimensional printing apparatus includes a tank, a platform, a lighting module, a control unit, a photosensitizer coating unit, and an exposure and development unit. The tank is filled with a liquid forming material, and the platform is movably disposed above the tank. The lighting module is used for providing light projecting toward the liquid forming material. The control unit coupled to the platform and the lighting module is configured to control the platform to move along a first direction, such that at least one layer object of a three-dimensional object is cured on the platform by layer. The photosensitizer coating unit is coupled to the control unit and configured to form at least one photosensitizer film on the layer object. The exposure and development unit is coupled to the control unit and configured to expose the photosensitizer film by exposing and developing to color the three-dimensional object.

An embodiment is disclosed of a method of making gloves, more particularly polyvinyl chloride (PVC) coated gloves. The method comprises providing a liner, and coating at least a part of the liner with a PVC paste to form a coating having an outer layer, applying particles of a soluble solid to the outer layer of the coating and curing the outer layer. Preferably, the method further comprises gelling the outer layer after applying the particles and contacting the gelled outer layer with a solvent before curing. Preferably, the soluble solid comprises a solid acid.

A catheter for ablating tissue is provided. The catheter comprises an elongated generally-tubular catheter body having proximal and distal ends. An electrode assembly is provided at the distal end of the catheter body. The electrode assembly including a porous electrode arrangement that is generally transverse to the catheter body. The porous electrode arrangement comprises one or more electrodes electrically connected to a suitable energy source and a porous sleeve mounted in surrounding relation to the one or more electrodes and defining an open space between the porous sleeve and the one more electrodes. One or more irrigation openings fluidly connect the open space to a lumen extending through the catheter through which fluid can pass. In use, fluid passes through the lumen in the catheter, through the one or more irrigation openings, into the open space and through the porous sleeve.

A forming tool for agglomerating thereon fibers from a slurry, the tool having a first end, a second end, a longitudinal axis, a forming surface and a non-forming surface, wherein the forming surface is perforated with a pattern of fluid passage ports extending from the forming surface to the non-forming surface; wherein the pattern of fluid passage ports demarks a surface area of the forming surface.