A sterile container including at least one hollow fiber filter module, especially dialyzer, which is accommodated in a hermetically sealed holding volume of a primary package and includes a blood compartment delimited by a blood inlet opening and a blood outlet opening, wherein a plurality of hollow fiber filter modules is arranged in the primary package and the sterile barrier of the blood compartment of each hollow fiber filter module inside the primary package is implemented by caps which close the blood inlet opening and the blood outlet opening of each hollow fiber filter module. A method of manufacturing such sterile container is also disclosed.

Systems and methods are disclosed that include an operation chamber, a plasma generator having at least one plasma head disposed within the operation chamber and in proximity to a profile formed by cutting a piece of tubing, and a mechanical motion module. The plasma generator generates a plasma treatment and applies the plasma treatment via the at least one plasma head to the profile to activate material on an end surface of the profile, within a lumen of the profile, or a combination thereof. Once the material of the profile is activated by the plasma treatment, the mechanical motion module manipulates the profile to close the lumen of the profile to aseptically seal the profile.

A seal obstructs the migration of particulates and precipitation into a pipe fusion chamber through its pipe stick entry and pipeline exit passages. Sheets of cloth serially overlap the anticipated center axis of a pipe stick/pipeline which will pass through the machine. The outer edge of each sheet is pleated and fixed to a frame contiguous with the perimeter of the passage and the inner edge of each sheet is gathered on an elastic band. When a face of a pipe stick/pipeline pushes the sheets away from the frame, the pleats and bands cooperate to allow the inner edges of the sheets to slide over the face and hug substantially the entire outer circumference of the pipe stick/pipeline.

An integrated system for fusing and sealing of a plurality of tubes is disclosed. The integrated system includes one or more fusing units configured to cut one or more tubes of multiple tubes simultaneously, and fusing the one or more tubes together along their respective cut ends; one or more sealing units configured to seal an end of the tube of the multiple tubes; and a control unit for controlling functions of the one or more fusing units and the one or more sealing units.

A tube seal apparatus including a sealing iron having a tube sealing end, an insulating shroud having a tube clamping end, wherein the sealing iron is at least partially disposed within the insulating shroud. The apparatus further includes an anvil having a cutting detail and a non-stick membrane disposed between the anvil and the tube clamping end of the insulating shroud. The sealing iron and insulating shroud are configured to advance towards a tube to be sealed positioned between the non-stick membrane and the anvil. The tube clamping end is configured to clamp the tube through the non-stick membrane. The sealing iron is configured to advance towards the tube to melt and seal the tube against the cutting detail through the non-stick membrane.

A blood bag sterile connection method includes the following steps: 1) placing blood bag tubes above the wire box, clamping positions to be cut by using the vascular clamps, and simultaneously moving the two vascular clamps in opposite directions; 2) heating the composite metal wire, and cutting the blood bag tubes by using the composite metal wire; 3) after cutting the blood bag tubes, aligning the blood bag tubes to be connected; 4) moving the two vascular clamps towards each other, rolling away the used composite metal wire, and rolling out a new composite metal wire; 5) connecting the blood bag tubes by heating the composite metal wire, and simultaneously moving the two vascular clamps towards each other; and 6) returning the wire box to the initial position, taking out the connected blood bag tubes, and returning the vascular clamps to the initial positions.

Delivering a blood processing solution to blood in a blood bag includes coupling a first tube to a vented spike at one end and to a Y-shaped tube connector at a second end. An in-line microbiotic barrier filter is coupled to the first tube between its ends. A second tube is coupled to a transfer bag at one end and to the Y-shaped tube connector at its other end. A third tube is coupled to the output of the Y-shaped tube connector and sealed at its distal end. The blood bag includes a fourth tube that is sealed at a distal end. The third tube is welded to the fourth tube using a sterile tubing welder, wherein a functionally-closed, sterile flow path through which the blood processing solution can flow into the blood bag is maintained.