An objective of the present invention is to provide a method for easily manufacturing a hydrophilized medical device of superior durability. In order to achieve the abovementioned objective, a method for manufacturing a medical device according to the present invention comprises a step for heating an aqueous package fluid, wherein, in the heating step, the aqueous package fluid contains one or more types of hydrophilic polymer, heating is performed with a substrate of the medical device at least partially is contact with the aqueous package fluid, and the following conditions (a) through (c) are all met. (a) The hydrophilic polymer is a (meth)acrylamide (co)polymer comprising two substituents comprising two or more carbon atoms on a nitrogen atom. (b) The mass % concentration of the hydrophilic polymer in the aqueous package fluid is in a range of 0.0001-30 mass %. (c) The pH of the aqueous package fluid after the heating step is in a range of 6.1-8.0.

In general, the disclosure relates to methods and compositions for preparing colorants useful for preparing pigmented hydrogels. The disclosure further relates to pigmented hydrogels comprising the disclosed colorants. In some instances, the colorant is an alcohol extract of an agro-material, such as turmeric, paprika, spinach, and/or pokorny woad or the colorants comprise one or more of: a carotenoid, chlorophyll-a, chlorophyll-b, a curcumoid, or indigorubin. Alternatively, the colorant can be carbon black. The disclosure further relates to contact lenses comprising the disclosed pigmented hydrogels.

Microchannels in hydrogels play an essential role in enabling a smart contact lens. A wearable contact lens is disclosed herein that uses microchannels and connected chambers located in poly-2-hydroxyethyl methacrylate (poly(HEMA)) hydrogel that is used in a commercial contact lens with three-dimensional (3D) printed mold. The corresponding capillary flow behaviors in these microchannels were investigated. Different capillary flow regimes were observed in these microchannels, depending on the hydration level of the hydrogel material. In particular, it was found that a peristaltic pressure could reinstate flow in a dehydrated microchannel, indicating the motion of eye-blinking may help tear flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na.sup.+ sensing capabilities were demonstrated in these microchannels. Micro-engineered contact lenses formed using poly(HEMA) hydrogel can be used for various biomedical applications such as eye-care and wearable biosensing.

The present invention relates to a wireless theranostic contact lens, which includes gold hollow nanowires having excellent safety and stability in vivo and excellent sensitivity and a controlled drug delivery system allowed to contain a high content of a drug for treating glaucoma.

The contact lens of the present invention is allowed to monitor intraocular pressure in real time and release an appropriate drug from the controlled drug delivery system according to a state of the intraocular pressure, thereby enabling personalized intraocular pressure adjustment.

The present invention could be used in medicine and relates to a method of producing ion-exchange polymeric hydrogels for eye treatment, which includes monomer copolymerization under ionizing radiation in presence of linking agent and ionites, when copolymerization is carried out gradually to obtain a prepolymer of desired viscosity for filling lens forms, and ionites introduction in the form of finely dispersed powder, filing the hydrogel into lens forms and subsequent copolymerization till an adequate ionizing dosage is performed providing a gel suitable for lenses formation, characterized in that the gel is also filled with pharmaceutically active agent in the form of finely dispersed powder prior to ionite introduction, and the size of particles of PAA is lower that the size of ionite particles. The present invention also relates to therapeutic hydrogel lenses produced in accordance with the above-mentioned method.

According to some aspects, this application provides devices and methods for treating cystinosis in a patient. Removable intra-ocular devices and contact lenses containing cystine-sequestering materials effective for uptake of cystine from the eyes of a patient having cystinosis are provided. Methods of making the cystine-sequestering contact lenses are also provided.

An intraocular lenses having a plurality of drug-containing microspheres attached to the intraocular lens. The intraocular lenses can be used for patients undergoing cataract surgery and reduces the need for recurrent surgery, follow-up treatment or postoperative eye-drops. Also provides a method for manufacturing such an intraocular lens and the use of an intraocular lens in the treatment of cataract.

A surface-modified contact lens, having a surface contact angle hysteresis of less than 15°, includes a lens body and a first surface modification layer disposed on a surface of the lens body. The first surface modification layer comprises a first reactive hydrophilic polymer. The surface of the lens body has a first functional group or a second functional group, and the first reactive hydrophilic polymer has a third functional group or a fourth functional group. A first covalent cross-link bond is formed between the surface of the lens body and the first surface modification layer. The first covalent cross-link bond is formed by reacting the first functional group or the second functional group of the surface of the lens body with the third functional group or the fourth functional group of the first reactive hydrophilic polymer.

The present invention provides a method for preparing a transparent hydrogel membrane, the method including: (a) preparing 6 to 10 wt % of a hyaluronic acid solution based on a total weight of a mixture by dissolving a hyaluronic acid in a basic aqueous solution; (b) mixing, with the hyaluronic acid solution, 0.01 to 0.05 wt % of a crosslinking agent based on the total weight of the mixture; and (c) shaping the transparent hydrogel membrane by pouring the mixture into a mold.

One embodiment of a contact lens includes a lens body configured to fit directly on the surface of the eye and legible characters positioned on the lens body. Another embodiment of a contact lens comprises a lens body including polymeric material and a lens enhancing material (e.g., ink, silicone material, medicament material, and the like) encapsulated in the polymeric material. The lens enhancing material can be in the form of isolated sections distributed in the surrounding polymeric material. Methods of making contact lenses include forming a first lens layer including a first surface, forming a pattern on the first surface, and forming a second lens layer over the pattern.