The present invention provides a smart contact lens including a sensor capable of non-invasively sensing an eye disease in real time and a drug reservoir, and smart glasses for controlling the smart contact lens.

According to some aspects, this application provides devices and methods for treating cystinosis in a patient. Removable intra-ocular devices and contact lenses containing cystine-sequestering materials effective for uptake of cystine from the eyes of a patient having cystinosis are provided. Methods of making the cystine-sequestering contact lenses are also provided.

A method for introducing an active compound into a soft hydrated contact lens comprising the steps of: providing a hypotonic aqueous solution having an osmolarity value less than 150 mOsm and an effective quantity of that active compound, immersing the soft contact lens in the aqueous hypotonic solution, subjecting the contact lens immersed in the aqueous hypotonic solution to mechanical vibrations having a power greater than 100 mW for a predetermined time.

According to some aspects, this application provides devices and methods for treating cystinosis in a patient. Removable intra-ocular devices and contact lenses containing cystine- sequestering materials effective for uptake of cystine from the eyes of a patient having cystinosis are provided. Methods of making the cystine-sequestering contact lenses are also provided.

A dosing system and method for delivery of contact lens formulation(s) to a contact lens forming mold. The system includes a carrier portion configured for holding a contact lens mold, and an alignment mandrel configured for retaining a lens formulation delivery device. The lens formulation delivery device is retained in a specified position relative to the contact lens mold for precise location of delivery of the lens formulation within the contact lens mold. A first lens formulation can be dosed to a center location in the mold, and a different second lens formulation can be dosed to a ring-shaped pattern around the center location, to form a contact lens having different center and edge characteristics.

A WS12-releasing contact lens is described as well as method of manufacturing the same. The WS12-releasing contact lens comprises a polymeric lens body and WS12 releasably adhered to the polymeric lens body, and releases from 0.05 g to 0.5 g WS12 after 1 hour in a release media or when worn by a human subject. The WS12-releasing contact lens can be comfortably worn by a symptomatic contact lens wearer and can increase the duration of comfortable lens wearing time and/or reduce lens awareness events and/or reduce contact lens dryness in a symptomatic contact lens wearer.

A contact lens assembly includes a cup, a dry contact lens that is not for being worn on an eye, a sealing layer removably connected to the cup, and a wetting liquid supply. The sealing layer and the cup jointly form an enclosed space that receives the dry contact lens therein and that does not accommodate any liquid. After at least one of the sealing layer and the cup produces an opening, the cup can receive a wetting liquid from the wetting liquid supply through the opening, such that the dry contact lens is immersed in the wetting liquid to form a wet contact lens that is suitable for being worn on the eye and that has a water content greater than a water content of the dry contact lens.

A contact lens includes one or more anionic comfort agents associated with a cationic monomer or a cationic polymer. A packaging system for the storage of a contact lens includes a sealed container containing the contact lens immersed in an aqueous packaging solution, wherein the aqueous packaging solution has an osmolality of at least about 200 mOsm/kg, a pH of about 6 to about 9 and is sterilized.

A packaging system for the storage of a contact lens comprising a sealed container containing an unused contact lens including one or more anionic comfort agents associated with a cationic monomer or a cationic polymer immersed in an aqueous packaging solution, wherein the aqueous packaging solution has an osmolality of at least about 200 mOsm/kg, a pH of about 6 to about 9 and is sterilized.

A contact lens having an amount of at least one cooling agent and at least one TRPV1 inhibitor releasably adhered is described as well as method of manufacturing the same. The contact lens can be comfortably worn by contact lens wearers and can increase the duration of comfortable lens wearing time and/or reduce lens awareness events and/or reduce contact lens dryness in a symptomatic contact lens wearer and further can reduce or avoid any stinging/burning sensation when the contact lens is first used or a short time thereafter.