A method of manufacturing articles of footwear, the method comprising: (a) positioning a first upper component around a last; (b) aligning the last with a cavity region of a midsole mold; (c) positioning an upper edge of the cavity region along the first upper component to form a sealed interface around the first upper component; (d) directing a midsole material into the cavity region to form a first midsole component that is attached or coupled to the first upper component; (e) releasing the first midsole component from the midsole mold and removing the first upper component from around the last; and (f) securing a first outsole component to the first midsole component to yield a first article of footwear.