The present disclosure relates to a bio printer to which a biomaterial freeze-hardening method is applied and a freeze-hardening method thereof. The bio printer may include: a plurality of dispensers configured to discharge a biomaterial inside a printing chamber; a printing plate module disposed below the dispensers so that the discharged biomaterial is placed thereon; a cooling module including one or more Peltier elements configured to cool the printing plate module, and a water block provided at a heating surface side of the Peltier elements and having a coolant flow path formed therein to circulate a coolant to dissipate heat generated from the Peltier elements; a coolant providing module configured to provide the coolant to the cooling module; a temperature sensor provided in the cooling module to calculate a temperature of a printing surface of the printing plate module; a printing controller configured to control the operation of the dispensers to print an output; and an output hardening controller configured to, upon completion of printing of the output by the printing controller, receive a detected value from the temperature sensor and control the cooling module and the coolant providing module to freeze-harden the output.

A biodegradable sampling bag for containing samples or the like, comprises a flexible enclosure defining a chamber adapted to contain therein the sample, the flexible enclosure being made of a plastic material, which contains an additive that renders the flexible enclosure biodegradable when exposed for a sufficient period of time to microbial action. The additive is adapted to enable microorganisms to metabolize the molecular structure of said flexible enclosure. The additive is effective in altering the polymer chain of the plastic material to allow microbial action of a suitable environment to colonize in and around the plastic material, whereby microbes can then form a biofilm on a surface of the flexible enclosure and secrete acids which break down the entire polymer chain. The flexible enclosure, when exposed to microbial action, is adapted to withstand biodegradation for a given period of time, typically of at least three months.

Provided is a biodegradable ocular implant for sustained drug delivery, including a first layer comprising a first biodegradable polymer, wherein the first layer contains a drug dispersed or dissolved therein. A multi-layered biodegradable ocular implant is also disclosed.

Composition and method for making a multi-layer bio-based film having one or more cavitated layers. In one aspect, the multilayer flexible film has polylactic acid, an inorganic filler, and a cavitation stabilizer making up at least one film layer. In one aspect, the barrier web has a cavitated bio-based film layer. In another aspect, the print web has a cavitated bio-based film layer.

Provided is a biodegradable resin molded product that exhibits excellent processability and sufficient strength as the molded product, is advantageous in terms of cost and at the same time, has excellent biodegradability under an environment, in particular, marine biodegradability, and a method for producing the same, and pellets used therefor. The molded product is produced using a biodegradable resin composition including a biodegradable resin and heavy calcium carbonate particles in a range by mass of 50:50 to 10:90.

A bioresorbable, implantable device having controlled drug delivery is disclosed herein. The bioresorbable, implantable device is configured as a film, a roll, a tube, and a stent. The bioresorbable, implantable device is configured to release an active ingredient (the “drug”) from the bioresorbable, implantable device when the bioresorbable, implantable device is implanted within a body. The bioresorbable, implantable device is configured to control the onset of the release of the drug, the sequence of drug delivery, and the duration of drug delivery by embedding the drug within at least one therapeutic layer positioned within bioresorbable, implantable device.

A process for producing a polymer material comprising: (a) providing a polymer material, which is carbon dioxide neutral and is selected from polyethylene, e.g. made from sugar cane ethanol, polypropylene and polystyrene, (b) providing a biodegradable additive, (c) blending the polymer material of step (a) with the biodegradable additive of step (b), wherein the biodegradable additive of step (b) is an organic mixture for the growing of naturally occurring organism comprising a fungal-bacterial mixture, e.g. a Penicillium-Bacillus mixture.

A method includes mixing a polymer, an organic solvent, and a porogen such that an initial paste is formed. The method also includes in-situ shaping the initial paste; creating a plurality of channels within the shaped paste and removing the organic solvent from the shaped paste such that a solidified perforated paste is formed; and leaching out the porogen from the solidified perforated paste such that a porous scaffold is formed.

A method for fabricating an embodiment of a medical device comprising the steps of: preparing a biodegradable polymeric structure; coating the biodegradable polymeric structure with a polymeric coat including a pharmacological or biological agent; cutting the structure into patterns configured to allow for crimping of the cut structure and expansion of the cut structure after crimping into a deployed configuration.

The invention relates to a biodegradable multilayer plastic article comprising at least 3 layers and a core that contains enzymes capable of degrading the polymers of the layers that surround the core.