A device for processing substrates improves processing quality during separation or punching of such substrates. The device has a first processing cylinder and a second processing cylinder for treating substrates, and between which the substrate can be inserted. The substrate undergoes processing as it passes through the cylinder nip between the processing cylinders by use of tool parts that are active therein, and which may be chosen from a group composed of cutting tools, punching tools, creasing tools, perforating tools and grooving tools. The first processing cylinder has a sheet holding system and one of the first processing cylinder and the second processing cylinder has a tool carrier for receiving a tool part. An impression cylinder, which is in surface contact with the second processing cylinder, is assigned to the second processing cylinder, on the side thereof that faces away from the first processing cylinder.

A device for processing substrates improves processing quality during separation or punching of such substrates. The device has a first processing cylinder and a second processing cylinder for treating substrates, and between which the substrate can be inserted. The substrate undergoes processing as it passes through the cylinder nip between the processing cylinders by use of tool parts that are active therein, and which may be chosen from a group composed of cutting tools, punching tools, creasing tools, perforating tools and grooving tools. The first processing cylinder has a sheet holding system and one of the first processing cylinder and the second processing cylinder has a tool carrier for receiving a tool part. An impression cylinder, which is in surface contact with the second processing cylinder, is assigned to the second processing cylinder, on the side thereof that faces away from the first processing cylinder.

The present invention relates to a device for treating substrates which device is modular and versatile in use. The device for treating substrates comprises a feeder and one or more first sub-structure modules which each comprise a pressure cylinder with devices for fixing a lift and a sheet-conveying device and one or more second sub-structure modules which respectively have a transport cylinder with openings formed on the cover surface thereof, and having devices for fixing a lift and a sheet conveying device. All of the first or second sub-structure modules have the same intersection point for connecting the sub-structure modules on one of the inlet and the exit side and they all can be equipped with an attachment module.

There is described a recto-verso printing press (100*) adapted to carry out simultaneous recto-verso printing of sheets, the printing press (100*) comprising a main printing group (5, 6, 15, 16, 25, 26) with first and second printing cylinders (5, 6) cooperating with one another to form a first printing nip between the first and second printing cylinders (5, 6) where first and second sides of sheets are simultaneously printed, the first printing cylinder (5) acting as a sheet conveying cylinder of the main printing group (5, 6, 15, 16, 25, 26). The printing press (100*) further comprises an additional printing group (7, 8, 17, 18, 27, 28) with third and fourth printing cylinders (7, 8) cooperating with one another to form a second printing nip between the third and fourth printing cylinders (7, 8) where the first and second sides of the sheets are simultaneously printed, the third printing cylinder (7) acting as a sheet conveying cylinder of the additional printing group (7, 8, 17, 18, 27, 28). The main printing group (5, 6, 15, 16, 25, 26) and the additional printing group (7, 8, 7, 18, 27, 28) are coupled to one another by means of an intermediate sheet conveying system comprising one or more sheet-transfer cylinders (10, 10, 10)interposed between the first and third printing cylinders (5, 7).

There is described a recto-verso printing press (100*) adapted to carry out simultaneous recto-verso printing of sheets, the printing press (100*) comprising a main printing group (5, 6, 15, 16, 25, 26) with first and second printing cylinders (5, 6) cooperating with one another to form a first printing nip between the first and second printing cylinders (5, 6) where first and second sides of sheets are simultaneously printed, the first printing cylinder (5) acting as a sheet conveying cylinder of the main printing group (5, 6, 15, 16, 25, 26). The printing press (100*) further comprises an additional printing group (7, 8, 17, 18, 27, 28) with third and fourth printing cylinders (7, 8) cooperating with one another to form a second printing nip between the third and fourth printing cylinders (7, 8) where the first and second sides of the sheets are simultaneously printed, the third printing cylinder (7) acting as a sheet conveying cylinder of the additional printing group (7, 8, 17, 18, 27, 28). The main printing group (5, 6, 15, 16, 25, 26) and the additional printing group (7, 8, 7, 18, 27, 28) are coupled to one another by means of an intermediate sheet conveying system comprising one or more sheet-transfer cylinders (10, 10, 10)interposed between the first and third printing cylinders (5, 7).

A sheet conveyance apparatus (1) is provided in a sheet-fed offset printing press (2) including a printing unit (11). The printing unit (11) includes an impression cylinder (13) configured to hold and convey a sheet (4) and a printing device (14) configured to print the sheet (4) held by the impression cylinder (13). The sheet conveyance apparatus (1) includes a transfer cylinder (28) configured to hand over the sheet (4) to the impression cylinder (13) of the printing unit (11), and a pressing cylinder (29) configured to press the sheet (4) held by the transfer cylinder (28) against an outer surface of the transfer cylinder (28). The pressing cylinder (29) can press the sheet (4) against the transfer cylinder (28), and sufficiently stretch it.

A sheet conveyance apparatus (1) is provided in a sheet-fed offset printing press (2) including a printing unit (11). The printing unit (11) includes an impression cylinder (13) configured to hold and convey a sheet (4) and a printing device (14) configured to print the sheet (4) held by the impression cylinder (13). The sheet conveyance apparatus (1) includes a transfer cylinder (28) configured to hand over the sheet (4) to the impression cylinder (13) of the printing unit (11), and a pressing cylinder (29) configured to press the sheet (4) held by the transfer cylinder (28) against an outer surface of the transfer cylinder (28). The pressing cylinder (29) can press the sheet (4) against the transfer cylinder (28), and sufficiently stretch it.

The invention provides for the use of pharmaceutical compositions comprising a thiazolide in the stimulation of the immune system in a subject in need thereof, thereby preventing and/or treating viral diseases, cancer and diseases caused by intracellular protozoan infections

The invention provides for the use of pharmaceutical compositions comprising a thiazolide in the stimulation of the immune system in a subject in need thereof, thereby preventing and/or treating viral diseases, cancer and diseases caused by intracellular protozoan infections