The present invention relates to a Spinacia oleracea plant comprising a nucleic acid molecule which when homozygously present provides at least intermediate resistance to Peronospora effusa races Pe: 1, Pe: 2, Pe: 3, Pe: 4, Pe: 5, Pe: 6, Pe: 7, Pe: 8, Pe: 9, Pe: 10, Pe: 11, Pe: 12, Pe: 13, Pe: 14, Pe: 15, Pe: 16, Pe: 17, Pe: 18, Pe: 19 and Pe: 20, wherein said nucleic acid molecule comprises a gene which comprises a coding sequence according to SEQ ID NO: 1 and a gene which comprises a coding sequence according to SEQ ID NO: 2, or a gene which comprises a coding sequence having at least 95.0% sequence identity to SEQ ID NO: 7 and comprises an insertion of sequence motif GAAATA between nucleotides 1235 and 1236 of SEQ ID NO: 7 and a gene which comprises a coding sequence having at least 95.0% sequence identity to SEQ ID NO: 8 and lacks a sequence according to SEQ ID NO: 14, wherein the 95.0% sequence identity is over the part of SEQ ID NO: 8 without the lacking sequence, or genes comprising the corresponding genomic sequences or genes encoding a protein having an amino acid sequence according to SEQ ID NO: 3, and a gene encoding a protein having an amino acid sequence according to SEQ ID NO: 4, or genes encoding proteins showing 95% sequence identity thereto. The invention further relates to a plant carrying the nucleic acid molecule and to methods of selecting, producing and growing such plants.