A cyclic packaging process, such as VFFS or HFFS, packages a product with a viscosity of ≥100,000 centipoise without leaving substantial air pockets in the package, by utilizing a means (38) for restricting upstream flow of viscous product in the strand of tubing (24). The result is that packages of uniform weight of the viscous product can be made without substantial air pockets therein, and without having to use metal clips. An apparatus (10) for carrying out the process is disclosed.

A cyclic packaging process, such as VFFS or HFFS, packages a product with a viscosity of ≥100,000 centipoise without leaving substantial air pockets in the package, by utilizing a means (38) for restricting upstream flow of viscous product in the strand of tubing (24). The result is that packages of uniform weight of the viscous product can be made without substantial air pockets therein, and without having to use metal clips. An apparatus (10) for carrying out the process is disclosed.

A table top appliance rapidly fills a pouch through some mechanical actuation or automation by inserting the pouch into the appliance and the machine fills the pouch. One embodiment of the food pouch filling station may be a mechanical version that includes a method to pump or push the contents of the container into the pouch. A second embodiment of the food pouch filling station may be an electric pump version that fills pouches and may have the option of controlling the amount of food dispensed. The food pouch filling station may also include a valve that connects to the pouch to control the flow to the pouch.

A table top appliance rapidly fills a pouch through some mechanical actuation or automation by inserting the pouch into the appliance and the machine fills the pouch. One embodiment of the food pouch filling station may be a mechanical version that includes a method to pump or push the contents of the container into the pouch. A second embodiment of the food pouch filling station may be an electric pump version that fills pouches and may have the option of controlling the amount of food dispensed. The food pouch filling station may also include a valve that connects to the pouch to control the flow to the pouch.

In some embodiments, an apparatus includes a housing and a mount. The housing includes a cover portion and a base portion. The cover portion and the base portion define an interior. The housing defines an opening via which the interior can be accessed from a region external to the housing. The mount is coupled to the base portion and configured to maintain a position of a fillable component within the interior of the housing such that an elastomeric membrane of the fillable component is aligned with the opening defined by the housing and a reservoir of the fillable component is accessible by a needle via the opening and the elastomeric membrane.

In some embodiments, an apparatus includes a housing and a mount. The housing includes a cover portion and a base portion. The cover portion and the base portion define an interior. The housing defines an opening via which the interior can be accessed from a region external to the housing. The mount is coupled to the base portion and configured to maintain a position of a fillable component within the interior of the housing such that an elastomeric membrane of the fillable component is aligned with the opening defined by the housing and a reservoir of the fillable component is accessible by a needle via the opening and the elastomeric membrane.

A vacuum controlled liquid delivery system, including a primary chamber; a manifold assembly affixed to the primary chamber, the manifold assembly comprising a feed line and an external pressure line; and a cap configured to reversibly engage the manifold assembly at one end and reversibly cap a syringe at another end, the cap comprising a septum and a porous plug, wherein when the cap is attached to the manifold assembly the feed line passes through the septum, and further wherein the porous plug seals upon contact with a liquid.

A vacuum controlled liquid delivery system, including a primary chamber; a manifold assembly affixed to the primary chamber, the manifold assembly comprising a feed line and an external pressure line; and a cap configured to reversibly engage the manifold assembly at one end and reversibly cap a syringe at another end, the cap comprising a septum and a porous plug, wherein when the cap is attached to the manifold assembly the feed line passes through the septum, and further wherein the porous plug seals upon contact with a liquid.

Production systems for producing a radioactive drug product include a hot cell having a radiation isolating shielding and a dispensing unit positioned within the hot cell. The dispensing unit includes a manipulator arm for manipulating a closure component of a vial. The system further includes a pneumatic line extending from the manipulator arm and through the radiation isolating shielding to a location outside of the hot cell and a pressure sensor connected to the pneumatic line and positioned outside of the radiation isolating shielding. The pressure sensor is operable to detect air pressure within the pneumatic line.

Production systems for producing a radioactive drug product include a hot cell having a radiation isolating shielding and a dispensing unit positioned within the hot cell. The dispensing unit includes a manipulator arm for manipulating a closure component of a vial. The system further includes a pneumatic line extending from the manipulator arm and through the radiation isolating shielding to a location outside of the hot cell and a pressure sensor connected to the pneumatic line and positioned outside of the radiation isolating shielding. The pressure sensor is operable to detect air pressure within the pneumatic line.