A method of filling containers with liquid product includes receiving a signal from at least one sensor corresponding to an amount of liquid product in a holding tank, the holding tank having an outlet for feeding the liquid product to a container filling apparatus; transferring liquid product from the outlet of the holding tank to an inlet of the container filling apparatus; and filling at least one container with the liquid product through at least one nozzle of the container filling apparatus for a predetermined fill time, wherein an amount of the liquid product dispensed during the predetermined fill time is based on a pressure at the outlet of the holding tank, wherein a head pressure in the holding tank is increased based on the signal from the sensor to control the pressure at the outlet of the holding tank as the liquid product is fed from the holding tank.

A method of filling containers with liquid product includes receiving a signal from at least one sensor corresponding to an amount of liquid product in a holding tank, the holding tank having an outlet for feeding the liquid product to a container filling apparatus; transferring liquid product from the outlet of the holding tank to an inlet of the container filling apparatus; and filling at least one container with the liquid product through at least one nozzle of the container filling apparatus for a predetermined fill time, wherein an amount of the liquid product dispensed during the predetermined fill time is based on a pressure at the outlet of the holding tank, wherein a head pressure in the holding tank is increased based on the signal from the sensor to control the pressure at the outlet of the holding tank as the liquid product is fed from the holding tank.

The present invention provides a filling nozzle obtained by using a resin selected from a cycloolefin polymer and a cycloolefin copolymer, or a filling nozzle including a tubular passage for supplying a pharmaceutical solution, and a filling port disposed at a lower end of the tubular passage, in which the tubular passage and the filling port have a circular peripheral cross-section, and an inner diameter of the passage of the filling port is larger than an inner diameter of the tubular passage disposed on an upstream side.

A vacuum controlled liquid delivery system, including a primary chamber; a manifold assembly affixed to the primary chamber, the manifold assembly comprising a feed line and an external pressure line; and a cap configured to reversibly engage the manifold assembly at one end and reversibly cap a syringe at another end, the cap comprising a septum and a porous plug, wherein when the cap is attached to the manifold assembly the feed line passes through the septum, and further wherein the porous plug seals upon contact with a liquid.

A vacuum controlled liquid delivery system, including a primary chamber; a manifold assembly affixed to the primary chamber, the manifold assembly comprising a feed line and an external pressure line; and a cap configured to reversibly engage the manifold assembly at one end and reversibly cap a syringe at another end, the cap comprising a septum and a porous plug, wherein when the cap is attached to the manifold assembly the feed line passes through the septum, and further wherein the porous plug seals upon contact with a liquid.

A dosing assembly for a filler including a valve assembly, a product hopper, a containment system and an attachment bracket. The dosing assembly can be coupled to a filler (for example, after filling, and prior to closing, capping or covering a container) for dispensing a dose of a fill material into the container. The fill material may comprise any number of different granular materials, including, but not limited to magnesium particles.

A dosing assembly for a filler including a valve assembly, a product hopper, a containment system and an attachment bracket. The dosing assembly can be coupled to a filler (for example, after filling, and prior to closing, capping or covering a container) for dispensing a dose of a fill material into the container. The fill material may comprise any number of different granular materials, including, but not limited to magnesium particles.

In some embodiments, an apparatus includes a housing and a mount. The housing includes a cover portion and a base portion. The cover portion and the base portion define an interior. The housing defines an opening via which the interior can be accessed from a region external to the housing. The mount is coupled to the base portion and configured to maintain a position of a fillable component within the interior of the housing such that an elastomeric membrane of the fillable component is aligned with the opening defined by the housing and a reservoir of the fillable component is accessible by a needle via the opening and the elastomeric membrane.

In some embodiments, an apparatus includes a housing and a mount. The housing includes a cover portion and a base portion. The cover portion and the base portion define an interior. The housing defines an opening via which the interior can be accessed from a region external to the housing. The mount is coupled to the base portion and configured to maintain a position of a fillable component within the interior of the housing such that an elastomeric membrane of the fillable component is aligned with the opening defined by the housing and a reservoir of the fillable component is accessible by a needle via the opening and the elastomeric membrane.

A liquid dispensing system for dispensing two or more liquids of different composition, viscosity, solubility and/or miscibility at high filling speeds into a container through a unitary dispensing nozzle to improve homogeneous mixing of such liquids, while said nozzle is an integral piece free of any movable parts.