A machine for dispensing an aerosol precursor composition for use with aerosol delivery devices. The machine may include a plurality of sources of dispensable, liquid aerosol precursor components. The plurality of sources may differ in the liquid aerosol precursor components being dispensable therefrom. The machine may include a user interface configured to allow a user to select an amount of the liquid aerosol precursor components for dispensing. The machine may also include a dispenser for dispensing the aerosol precursor components in response to the selection made on the user interface.

A machine for dispensing an aerosol precursor composition for use with aerosol delivery devices. The machine may include a plurality of sources of dispensable, liquid aerosol precursor components. The plurality of sources may differ in the liquid aerosol precursor components being dispensable therefrom. The machine may include a user interface configured to allow a user to select an amount of the liquid aerosol precursor components for dispensing. The machine may also include a dispenser for dispensing the aerosol precursor components in response to the selection made on the user interface.

Production systems for producing a radioactive drug product include a hot cell having a radiation isolating shielding and a dispensing unit positioned within the hot cell. The dispensing unit includes a manipulator arm for manipulating a closure component of a vial. The system further includes a pneumatic line extending from the manipulator arm and through the radiation isolating shielding to a location outside of the hot cell and a pressure sensor connected to the pneumatic line and positioned outside of the radiation isolating shielding. The pressure sensor is operable to detect air pressure within the pneumatic line.

Production systems for producing a radioactive drug product include a hot cell having a radiation isolating shielding and a dispensing unit positioned within the hot cell. The dispensing unit includes a manipulator arm for manipulating a closure component of a vial. The system further includes a pneumatic line extending from the manipulator arm and through the radiation isolating shielding to a location outside of the hot cell and a pressure sensor connected to the pneumatic line and positioned outside of the radiation isolating shielding. The pressure sensor is operable to detect air pressure within the pneumatic line.

Methods for manufacturing a plastic container and for filling it with a fill product are described. The methods include introducing a perform into a blow mold, pressuring the preform with a blowing medium, evacuating the interior space of the container to an underpressure, and introducing a fill product in the interior space at an overpressure.

Methods for manufacturing a plastic container and for filling it with a fill product are described. The methods include introducing a perform into a blow mold, pressuring the preform with a blowing medium, evacuating the interior space of the container to an underpressure, and introducing a fill product in the interior space at an overpressure.

The present invention provides a filling nozzle obtained by using a resin selected from a cycloolefin polymer and a cycloolefin copolymer, or a filling nozzle including a tubular passage for supplying a pharmaceutical solution, and a filling port disposed at a lower end of the tubular passage, in which the tubular passage and the filling port have a circular peripheral cross-section, and an inner diameter of the passage of the filling port is larger than an inner diameter of the tubular passage disposed on an upstream side.

A system and method of use of the system, the system including: a tank configured to store a fluid; a positive displacement pump in fluid communication with the tank; and a filling needle in fluid communication with the pump and configured to form a releasable sealed attachment to a cartridge; wherein the pump is configured to pump measured doses of the fluid received from the tank through the needle into the cartridge.

A system and method of use of the system, the system including: a tank configured to store a fluid; a positive displacement pump in fluid communication with the tank; and a filling needle in fluid communication with the pump and configured to form a releasable sealed attachment to a cartridge; wherein the pump is configured to pump measured doses of the fluid received from the tank through the needle into the cartridge.

A filler assembly comprising a pouch preheat zone, a pouch sterilization zone, and a pouch flush zone. The preheat zone includes a preheat nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and a preheat vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum. The pouch sterilization zone includes a sterilization nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and, a sterilization vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum. The pouch flush zone includes a pouch flush nozzle assembly having an inlet and an outlet, the outlet engageable with a pouch assembly, and, a pouch flush vacuum nozzle assembly having an inlet engageable with a pouch assembly and an outlet attachable to a vacuum.