A container holding device for holding one or more containers includes: a base plate having an upper surface, a bottom surface, and one or more holes each extending from the upper surface to the bottom surface and having a central symmetry axis L.sub.axis orthogonal to the base plate; and two or more holding elements that are located around each hole beneath the bottom surface of the base plate. The holding elements are configured to: contact an outer surface of a container that is placed into the container holding device at a bottom edge of a top region of the container, such that the container hangs in the container holding device in a first position p1 in which the holding elements do not exert any force on the outer surface of the container that is radial; and contact the outer surface of the container in a shoulder region.

The invention proposes an apparatus for transporting a container relative to a filling station, comprising at least one filling station (48) for filling at least one container (36), and also comprising at least one container mount (38) for transporting the container (36) relative to the filling station (48), characterized in that at least one drive surface (13) and at least one mover (20), which can be coupled in particular magnetically to the drive surface (13), are provided, wherein the mover (20) is arranged on the drive surface (13) such that it can be displaced and/or rotated in at least two degrees of freedom, and in that the container mount (38) is connected to the mover (20).

A method of preparing a double chamber container (1) comprises the steps of: filling a substance in the interior of the double chamber container (1), freeze-drying the substance inside the double chamber container(1), inserting a middle plunger (81) in the interior of the double chamber container (1) such that a distal chamber and a proximal chamber are formed, wherein the middle plunger (81) seals the distal chamber from the proximal chamber and wherein the freeze-dried substance is inside the distal chamber, filling a reconstitution medium in the proximal chamber of the double chamber container (1), and sealing a distal opening (14) of the double chamber container (1) and a proximal opening (13) of the double chamber container (1). The method particularly also comprises the steps of providing a holder (2) having a seat (21) designed to receive the double chamber container (1) in an upright position and arranging the double chamber container (1) in the seat (21) of the holder (2) such that, in the upright position, a distal end side (12) of the double chamber container (1) extends downwardly and a proximal end side (13) of the double chamber container (1) extends upwardly. Thereby, the double chamber container (1) is arranged in the seat (21) of the holder (2) while the substance is filled in the interior of the double chamber container (1), while the substance is freeze-dried inside the double chamber container (1), while the middle plunger (81) is inserted in the interior of the double chamber container (1), while the reconstitution medium is filled in the proximal chamber of the double chamber container (1), and while the proximal opening (13) of the double chamber container (1) is sealed.

A device (1) for closing a chamber of a container having an opening for accessing the chamber comprises a plunger, a plunger seat (11), a container carrier (13) and a spacer (12). The plunger seat (11) releasably holds the plunger in a predefined alignment. The container carrier (13) is arranged to be connected to the container in a predefined position and alignment in relation to the opening of the container. The spacer (12) is arranged to position and align the plunger seat (11) adjacent to and distant from the container carrier (13) such that the opening of the container is open when the container is connected to the container carrier (13).

The present invention is directed to methods for filling a container wherein the filled container has no headspace. The present invention is further directed to methods for stabilizing an aqueous drug substance solution by filling a container with the aqueous drug substance solution wherein the filled container has no headspace. The present invention is further directed to methods for detecting headspace in a container.

Various nesting structures for storage, transport and/or assembly of dispensers and containers are described herein. For example, a packaging structure for a plurality of drug dispensers may include a support surface and a plurality of dispenser covers arranged on the support surface, where at least one dispenser cover includes a locking flexure member configured to couple a dispenser to the at least one dispenser cover.

A packaging system for sealing a medicine container having a filling opening with a stopper includes a container tray having a container cell for receiving and stabilizing the medicine container. A shuttle has an exterior surface and an interior surface. The interior surface is configured for releasably securing the stopper. The shuttle is configured to release the stopper into the fill opening upon application of a releasing force to the exterior surface of the shuttle. A shuttle tray has a shuttle cell. The shuttle cell forms a body with a proximal opening, an interior space, a bottom inner surface opposite the proximal opening, and a side inner surface. The shuttle cell releasably secures the shuttle.

The present invention relates to a device for vacuum and vent tube stoppering a medical container. The device includes a main body defining an internal volume that has a first variable pressure chamber configured to be connected to a vacuum pump, the main body being configured to receive the proximal end of a medical container so that said medical container is in communication with the first variable pressure chamber. A vent device including a vent tube is moveable inside the internal volume of the main body along a longitudinal axis between a proximal rest position and a distal operative position. A piston rod is moveable inside the internal volume of the vent tube along the longitudinal axis between a proximal rest position and a distal operative position. A container holder system is provided in the main body, in communication with the first variable pressure chamber.

An applicator assembly (100) for closing a sample container (500) with a plug (16) is proposed. The applicator assembly comprises a magazine (102) configured to store a string (10) comprising polymer-based material, an insertion device (104) configured to insert an end piece (12) of the string at least partly into an opening (502) of the sample container (500), and a drive system (106) configured to supply at least a part of the string (10) from the magazine (102) to the insertion device (104). The applicator assembly further comprises a separator (108) configured to separate the end piece (12) from the string, such that the end piece (12) forms a plug (16) closing the sample container (500).