A beverage brewing cartridge includes a base and a plug. The base includes a sidewall, a fillable end having an opening, and a closed end. The plug is configured to close off the opening. A method of constructing a brewing cartridge includes placing the base of the beverage brewing cartridge on a cartridge seat of a cartridge tool with the closed end against the cartridge seat. A cartridge lock retains the base against the cartridge tool. A portion of brewing material is scooped and poured into the base through a mouth of the cartridge lock and the opening of the fillable end of the base, and then tamped into the base. The plug is positioned above and aligned with the opening of the fillable end of the base, and seated into the opening to close the opening, thereby completing construction of the brewing cartridge.

An automatic cosmetic bottle capping having a first conveyor belt, a second conveyor belt, and a third conveyor belt. A sliding convex is provided at a surface of the first conveyor belt, a capper is movably sleeved on the first conveyor belt, a suction tip is provided in the capper, rolling balls are provided inside the capper, a through-hole is provided in an external surface of the capper, a capping claw is provided on a lower end of the capper, a positioning plate is provided on an upper end of the capper, springs are provided at a lower end of the positioning plate, a hole plug is movably connected outside the through-hole, and a cap is provided on a front end of the second conveyor belt.

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligned concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

An injector may include a container having a wall with an interior surface and a seal assembly with an interior surface, the interior surfaces of the wall and the seal assembly defining a closed sterile reservoir filled with a drug product. The injector may also include a fluid delivery system comprising a clean, unsheathed, rigid container needle having a point disposed only partially through the seal assembly in a storage state, and disposed through the interior surface of the seal assembly into the sterile reservoir in a delivery state. Further, the injection may include an actuator that is adapted to move the container needle from the storage state to the delivery state.

A packaging system for aseptically packaging, filling, and sealing medical containers includes a container tray (100) having a container cell (120) for receiving and stabilizing the medicine container. The system also includes a stopper holder (300) with a stopper cell (320) forming a closed body with a distal opening, an interior space, a proximal wall opposite the distal opening, and a proximal outer surface (330). The stopper cell (320) is configured for releasably securing the stopper and releasing the stopper into a fill opening of the medicine container when a compressive force is exerted on the proximal outer surface of the stopper cell (320).

A packaging system for sealing a medicine container having a filling opening with a stopper includes a container tray having a container cell for receiving and stabilizing the medicine container. A shuttle has an exterior surface and an interior surface. The interior surface is configured for releasably securing the stopper. The shuttle is configured to release the stopper into the fill opening upon application of a releasing force to the exterior surface of the shuttle. A shuttle tray has a shuttle cell. The shuttle cell forms a body with a proximal opening, an interior space, a bottom inner surface opposite the proximal opening, and a side inner surface. The shuttle cell releasably secures the shuttle.

A method of preparing a prefilled syringe (1), comprises (i) obtaining a syringe barrel (11) having an open end (111) and a tip (112) with an orifice (113) essentially opposite to the open end (111), and a needle adaptor cap (12) assembled on the tip (112) of the syringe barrel, wherein the needle adaptor cap (12) has a rubber element (121) tightly sealing the orifice (113) of the tip (112) of the syringe barrel (11) and the syringe barrel (11) together with the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) is sterilized by a first sterilizing comprising a main step of exposing the syringe barrel (11) together with the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) to ethylene oxide for about 5 hours to about 60 hours at a relative humidity of about 40% to about 100% and at a temperature of about 30° C. to about 60° C.; (ii) filling a drug substance (14) through the open end (111) of the syringe barrel (11) into an interior of the syringe barrel; (iii) sealing the interior of the syringe barrel (11) by advancing a rubber stopper (13) through the open end (111) of the syringe barrel (11); (iv) packaging the syringe barrel (11) together with the rubber stopper (13) sealing the interior of the syringe barrel (11) and the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11); and (v) second external surface sterilizing the packaged syringe barrel (11) together with the rubber stopper (13) sealing the interior of the syringe barrel (11) and the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11). The rubber element (121) of the needle adaptor cap (12) and the rubber stopper (13) are made of a rubber material having a comparably low oxygen transmission rate such as, at 1 atmosphere, of not more than 64 cubic centimeter per square meter and day. The second external surface sterilizing comprises a main step of exposing the packaged syringe barrel (11) together with the rubber stopper (13) sealing the interior of the syringe barrel (11) and the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) to ethylene oxide for about 3 hours to about 30 hours at a relative humidity of about 40% to about 100% and at a temperature of about 25° C. to about 45° C. At least one of the duration, the relat

In one general aspect, a method for filling multiple containers with a pharmaceutical product is disclosed, which comprises decontaminating sealed nested materials in a transfer chamber, removing from the sealed nested materials one or both of a container nest holding the multiple containers and a closure nest holding multiple closures, transferring from the transfer chamber to a controlled environment enclosure the removed nest, aseptically filling the containers with the pharmaceutical product, and closing the containers with the multiple closures. The nests are configured to allow multiple closures and containers to be simultaneously aligined concentrically, and closed simultaneously. Spring-loaded retaining structures on the closure nest allow it to releasably retain multiple closures above the corresponding multiple containers. In some embodiments the spring-loaded features are monolithically integrated with the closure nest. The product may be lyophilized in partially sealed containers while the sealing closures are releasably retained by the closure nest.

An apparatus and a method for closing containers with closures is disclosed. The apparatus includes a transport wheel, a feed device, and a closing device. The transport wheel continuously transports the containers and includes a plurality of transport wheel receptacles. Each transport wheel receptacle is able to receive a container. The transport wheel is designed to be rotatable about a transport wheel axis. The feed device is capable of clocked feeding of the containers to the transport wheel in a feed region of the apparatus. The closing device is arranged to close containers while they are accommodated in the transport wheel receptacles of the transport wheel. A method for closing the containers includes feeding containers to the transport wheel and closing the containers with a closing device.

An apparatus for closing pharmaceutical containers with closure elements, and a system for processing pharmaceutical containers. The closure elements include a first face and a second face. The apparatus includes a feed unit with a feed path in which closure elements can be fed separately without contacting the first face; a receiving body with a receptacle for the closure element, the closure element being transferrable from the feed path into a receiving position in the receptacle; and a device for turning the receiving body from an initial position into an end position and transferring the closure element from the receiving position into a placed position in which the closure element is positioned on the container or at a distance to the container such that the first face points in the direction of the container interior.