A pressurized phase for vapor treating a reusable metal keg includes filling the keg with pressurized water vapor through an inlet and then interrupting the connection, thus initiating a dwell time. During this dwell time, condensate forms on the inner surfaces of the keg. Meanwhile, one causes relative movement between the water vapor and the keg's inner walls.

The present invention relates to an intravenous infusion dosage form of pemetrexed or its pharmaceutically acceptable salt, having long term stability.

The present invention relates to an intravenous infusion dosage form of pemetrexed or its pharmaceutically acceptable salt, having long term stability.

A PET bottle sterilization apparatus is for consecutively sterilizing multiple PET bottles (B) while conveying them, and includes a hydrogen peroxide introducing means (5) for introducing hydrogen peroxide into a PET bottle (B) so as to sterilize its interior and a hot air supplying means (6) for introducing hot air into the sterilized PET bottle (B) so as to eliminate hydrogen peroxide remaining inside it. This apparatus includes a plasma introducing means (P) for introducing plasma into a PET bottle (B) by injecting plasma through a nozzle at at least one time point among a time point before hydrogen peroxide is introduced into the PET bottle (B), a time point after hydrogen peroxide was introduced into the PET bottle (B) and furthermore before hot air is introduced into the PET bottle (B), and a time point after hot air was introduced into the PET bottle (B).

A PET bottle sterilization apparatus is for consecutively sterilizing multiple PET bottles (B) while conveying them, and includes a hydrogen peroxide introducing means (5) for introducing hydrogen peroxide into a PET bottle (B) so as to sterilize its interior and a hot air supplying means (6) for introducing hot air into the sterilized PET bottle (B) so as to eliminate hydrogen peroxide remaining inside it. This apparatus includes a plasma introducing means (P) for introducing plasma into a PET bottle (B) by injecting plasma through a nozzle at at least one time point among a time point before hydrogen peroxide is introduced into the PET bottle (B), a time point after hydrogen peroxide was introduced into the PET bottle (B) and furthermore before hot air is introduced into the PET bottle (B), and a time point after hot air was introduced into the PET bottle (B).

The present invention relates to improved contact lens products which not only have an improved and sustainable wettability. The contact lens product of the invention comprises a soft hydrogel contact lens immersed and autoclaved in a packaging solution including a polyoxyethylene-polyoxybutylene block copolymer and a high molecular weight copolymer of N-vinylpyrrolidone and at least one amino-containing vinylic monomer. The present invention also provides methods for making contact lens products of the invention.

The present invention relates to improved contact lens products which not only have an improved and sustainable wettability. The contact lens product of the invention comprises a soft hydrogel contact lens immersed and autoclaved in a packaging solution including a polyoxyethylene-polyoxybutylene block copolymer and a high molecular weight copolymer of N-vinylpyrrolidone and at least one amino-containing vinylic monomer. The present invention also provides methods for making contact lens products of the invention.

A system for the sterile filling of containers for pharmaceutical products, which includes a device for sterilizing containers and a machine for filling sterilized containers, wherein the device for sterilizing containers includes at least one autoclave, and wherein the system includes an automated container-accumulation device and means for automatically transporting the containers sterilized in the autoclave from said autoclave to the container-filling machine via said container-accumulation device.

A system for the sterile filling of containers for pharmaceutical products, which includes a device for sterilizing containers and a machine for filling sterilized containers, wherein the device for sterilizing containers includes at least one autoclave, and wherein the system includes an automated container-accumulation device and means for automatically transporting the containers sterilized in the autoclave from said autoclave to the container-filling machine via said container-accumulation device.

A sealed, empty pouch, wherein the interior of the pouch is particle and pyrogen free, is made by (i) molding a tubular film including an inner surface and an outer surface, and blowing or otherwise directing micro-filtered air and/or other gas through the tubular film during molding; (ii) flattening the molded tubular film; (iii) sealing the flattened tubular film at spaced locations, cutting the sealed film at the spaced locations, and forming a plurality of empty pouches; (iv) over-molding a fitment to the outer surface of each of a plurality of empty pouches and forming a fluid-tight seal between the fitment and the interior of the pouch; and (v) preventing the collection of particles on the inner surface of each pouch, and the exposure of each such inner surface to an ambient atmosphere throughout steps (i) through (iv).