Provided are a method and an apparatus for sterilizing a sleeve that can shorten a sterilization process for a paper container sleeve and ensure a sterilization effect. In a method for sterilizing a sleeve in an aseptic filling system that molds the sleeve into a paper container having a bottomed tubular shape by closing surfaces of an open end part of the sleeve and performs sterilization, filling and sealing of the paper container, the sleeve being a tubular body having walls formed by laminating at least paper, in a state where the sleeve stands in a columnar shape, heated air containing a sterilizer is blasted to an inner surface of the sleeve that is to form a bottom part of the paper container to perform sterilization of the inner surface of the bottom part and heating for the closing at the same time.

Provided are a method and an apparatus for sterilizing a sleeve that can shorten a sterilization process for a paper container sleeve and ensure a sterilization effect. In a method for sterilizing a sleeve in an aseptic filling system that molds the sleeve into a paper container having a bottomed tubular shape by closing surfaces of an open end part of the sleeve and performs sterilization, filling and sealing of the paper container, the sleeve being a tubular body having walls formed by laminating at least paper, in a state where the sleeve stands in a columnar shape, heated air containing a sterilizer is blasted to an inner surface of the sleeve that is to form a bottom part of the paper container to perform sterilization of the inner surface of the bottom part and heating for the closing at the same time.

A preform is sterilized by a preform sterilizer. The preform is blow-molded by a blow-molding device to manufacture a container. Next, the container is filled with a culture medium by a filling device without sterilizing the container by a container sterilizer, and the container is plugged by a plugging device. Thereafter, it is verified how much microorganism survive or propagate in the culture medium in the container. A degree of sterilization in the container sterilizer is adjusted on the basis of a verification result.

A method for manufacturing a container product is disclosed. The method includes filling a container with contents; forming information on the container, the information including a number, a letter, and an image, the information being formed by a first pattern, the first pattern being made up of a collection of second patterns; and heating or cooling the container before or after the forming of the information on the container.

A packaging system for the storage of an ophthalmic device is disclosed. The packaging system comprises a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising (a) one or more osmoprotectants, (b) one or more poloxamer comfort agents and (c) one or more polyol demulcents, wherein the aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized.

A packaging system for the storage of an ophthalmic device is disclosed. The packaging system comprises a sealed container containing one or more unused ophthalmic devices immersed in an aqueous packaging solution comprising (a) one or more osmoprotectants, (b) one or more poloxamer comfort agents and (c) one or more polyol demulcents, wherein the aqueous packaging solution has an osmolality of at least about 150 mOsm/kg, a pH of about 6 to about 9 and is heat sterilized.

This invention relates to a dilute, ready-to-use solution of phenylephrine hydrochloride having improved stability and utility. In a particular embodiment, the formulation consists of an injectable form of phenylephrine hydrochloride with edetate disodium chelating agent in place of any sodium metabisulfite antioxidants to improve the solution's ability to remain stable and active in a dilute state after prolonged storage. This invention also relates to a form for injection of the solution that includes packaging the solution in a single-use container, as well as a form for containing the ready-to-use solution in a sterile, sealed container. Lastly this invention relates to methods of making the injectable solution for use in a single-use container, as well as for containment in a sterile, sealed container.

This invention relates to a dilute, ready-to-use solution of phenylephrine hydrochloride having improved stability and utility. In a particular embodiment, the formulation consists of an injectable form of phenylephrine hydrochloride with edetate disodium chelating agent in place of any sodium metabisulfite antioxidants to improve the solution's ability to remain stable and active in a dilute state after prolonged storage. This invention also relates to a form for injection of the solution that includes packaging the solution in a single-use container, as well as a form for containing the ready-to-use solution in a sterile, sealed container. Lastly this invention relates to methods of making the injectable solution for use in a single-use container, as well as for containment in a sterile, sealed container.

The present invention refers to an intravenous infusion dosage form comprising a composition containing pemetrexed or its pharmaceutically acceptable salt, an osmagent and an aquous vehicle. The composition is present in a flexible infusion container containing an inert gas in the headspace. Additionally, a second container may be present surrounding the flexible infusion container.

The present invention refers to an intravenous infusion dosage form comprising a composition containing pemetrexed or its pharmaceutically acceptable salt, an osmagent and an aquous vehicle. The composition is present in a flexible infusion container containing an inert gas in the headspace. Additionally, a second container may be present surrounding the flexible infusion container.